1 research outputs found
One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with <i>N</i>‑Tosylhydrazones: Access to 1,2,4-Triazines
A new, three-step,
telescoped reaction sequence for the regioselective
conversion of <i>N</i>-tosyl hydrazones and aziridines to
3,6-disubstituted and 3,5,6-trisubstituted 1,2,4-triazines is described.
The process involves an efficient nucleophilic ring opening of the
aziridine, giving access to a wide range of aminohydrazones, isolated
with excellent yields. A “one-pot” procedure, combining
the ring opening with a cyclization and an oxidation step, allows
the preparation of diversified triazines in good yields