O processo de viver e ser saudável das mulheres no climatério El proceso de vivir y ser saludable de las mujeres y el climaterio The living process and being healthy for women and climacteric

<abstract language="spa">Este estudo teve como objetivo compreender como se dá o processo de viver de mulheres no climatério. Foi desenvolvido com base na abordagem qualitativa, utilizando multimétodos participativos, com nove mulheres do Núcleo da Terceira Idade (NETI) da Universidade Federal de Santa Catarina (UFSC). Os dados foram coletados por entrevistas e reuniões de grupos e analisados por meio da análise de conteúdo. Da análise dos dados, emergiram as unidades de significado, que deram origem às seguintes categorias: afirmando-se como mulher; experienciando o climatério e o envelhecimento; interagindo no cotidiano e mantendo as singularidades; abrindo caminhos para a vivência da cidadania. Com base no resultado do estudo, o viver das mulheres no período do climatério mostrou-se como um processo complexo, dinâmico, paradoxal, em que o envelhecimento e a possibilidade de adoecer se colocam como desafios maiores e os avanços nas perspectivas pessoais, culturais e sociais, como conquistas especiais.<br>The aim of this study was to comprehend the living process of women in the period of climacteric. It was developed based on qualitative approach, using multi-participatory methods, with nine women of the Third Age Center (NETI), of the Federal University of Santa Catarina, Brazil (UFSC). Data was collected through interviews and meetings of groups and analyzed by analysis of the content. From the data analysis, emerged the units of meaning, which led the following categories: affirming one's self as a woman; experiencing the climacteric and ageing; interacting in the day-to-day and maintaining singularities; and opening paths to the experience of citizenship. Based on the result of the study, the living of women in the climacteric period is a complex, dynamic and paradoxical process, in which the aging and the possibility of becoming ill arise as greater challenges, and advances in the personal, cultural and social perspectives as special achievements

Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates*.

Antibody-drug conjugates (ADCs) are a new class of therapeutics that combine the lethality of potent cytotoxic drugs with the targeting ability of antibodies to selectively deliver drugs to cancer cells. In this study we show for the first time the synthesis of a reactive-oxygen-species (ROS)-responsive ADC (VL-DAB31-SN-38) that is highly selective and cytotoxic to B-cell lymphoma (CLBL-1 cell line, IC50 value of 54.1 nM). The synthesis of this ADC was possible due to the discovery that diazaborines (DABs) are a very effective ROS-responsive unit that are also very stable in buffer and in plasma. DFT calculations performed on this system revealed a favorable energetic profile (ΔGR=-74.3 kcal mol-1 ) similar to the oxidation mechanism of aromatic boronic acids. DABs' very fast formation rate and modularity enabled the construction of different ROS-responsive linkers featuring self-immolative modules, bioorthogonal functions, and bioconjugation handles. These structures were used in the site-selective functionalization of a VL antibody domain and in the construction of the homogeneous ADC