Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury.

Activated protein C (APC) has emerged as a novel therapeutic agent for use in selected patients with severe sepsis, even though the mechanism of its benefit is not well established. APC has anticoagulant, anti-inflammatory, antiapoptotic, and profibrinolytic properties, but it is not clear through which of these mechanisms APC exerts its benefit in severe sepsis. Focus has recently turned to the role of APC in maintaining endothelial barrier function, and in vitro and in vivo studies have examined this relationship. This article critically reviews these studies, with a focus on potential mechanisms of action

Reforming the Rentier State: The Imperatives for Change in the Gulf

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A Comprehensive Study of the Male Voice Mutation

This research project is a comprehensive study of the male voice mutation. The beginning of the document will provide a brief history of the approach to the male voice mutation dating back to the ancient Greek and Roman times. Information and pedagogical middle school classroom application of the contemporary voice mutation theories by Duncan McKenzie, Irvin Cooper, Frederick Swanson, and John Cooksey will also be discussed. The second section will include an analysis of individual voice testing results from boys in 5th, 6th, 7th, and 8th grade at Miller South School for the Visual and Performing Arts in Akron, Ohio. Age, previous piano and other music experience, range, pitch matching, tonal memory, sense of rhythm, and vocal strength were evaluated and documented on a standard individual vocal assessment form. The test group of the research were the boys from the 7th grade choir. The project culminated in selecting appropriate choral warm-ups and literature to select for the boys in the 7th grade choir