20 research outputs found

    ESTIMACIÓN Y CAUSAS DE DIFERENCIAS SALARIALES ENTRE PROFESIONALES EN TRES INSTITUCIONES COSTARRICENSES

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    El presente estudio se dirigió a estimar las diferencias salariales y sus posibles causas, entre los hombres y las mujeres profesionales en tres instituciones costarricenses. La información se obtuvo encuestando a 127 profesionales que laboraban en esas instituciones durante el primer semestre del 2010.La investigación reveló que existen diferencias salariales que se pueden explicar por: la presencia de niños en el hogar, la capacitación, las posibilidades de ascenso y las interrupciones laborales. Aunque los resultados sólo son relevantes para la situación en las tres instituciones en estudio; permiten tomar conciencia de la importancia del tema a nivel nacional y las implicaciones dentro del mercado para el sector femenino

    La décima en el Perú

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    "Selección de casi trescientas décimas sobre los rasgos peruanos en la composición y el canto de la décima, sobre los decimistas y sus usos en "los desafíos, etc.; dirigida a exponer el desarrollo temporal de la décima en el Perú; también refiere con frescura la controversia cotidiana y el valor testimonial de los «últimos decimistas", que son vistos como expresión del quehacer artístico, del folklore, de una gruesa parte de nuestras clases populares, la población urbana y rural de raíces negras". ― Presentación

    The Landscape of A-to-I RNA Editome Is Shaped by Both Positive and Purifying Selection

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    <div><p>The hydrolytic deamination of adenosine to inosine (A-to-I editing) in precursor mRNA induces variable gene products at the post-transcription level. How and to what extent A-to-I RNA editing diversifies transcriptome is not fully characterized in the evolution, and very little is known about the selective constraints that drive the evolution of RNA editing events. Here we present a study on A-to-I RNA editing, by generating a global profile of A-to-I editing for a phylogeny of seven <i>Drosophila</i> species, a model system spanning an evolutionary timeframe of approximately 45 million years. Of totally 9281 editing events identified, 5150 (55.5%) are located in the coding sequences (CDS) of 2734 genes. Phylogenetic analysis places these genes into 1,526 homologous families, about 5% of total gene families in the fly lineages. Based on conservation of the editing sites, the editing events in CDS are categorized into three distinct types, representing events on singleton genes (type I), and events not conserved (type II) or conserved (type III) within multi-gene families. While both type I and II events are subject to purifying selection, notably type III events are positively selected, and highly enriched in the components and functions of the nervous system. The tissue profiles are documented for three editing types, and their critical roles are further implicated by their shifting patterns during holometabolous development and in post-mating response. In conclusion, three A-to-I RNA editing types are found to have distinct evolutionary dynamics. It appears that nervous system functions are mainly tested to determine if an A-to-I editing is beneficial for an organism. The coding plasticity enabled by A-to-I editing creates a new class of binary variations, which is a superior alternative to maintain heterozygosity of expressed genes in a diploid mating system.</p></div

    Gene ontology (GO) enrichment analysis on different types of A-to-I RNA editing events from <i>D</i>. <i>melanogaster</i>.

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    <p>Analyses were performed on genes of each editing type with the GOseq package [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006191#pgen.1006191.ref056" target="_blank">56</a>] using the <i>Hypergeometric test</i> with <i>p-values</i> adjusted by false discovery rate (FDR) control procedure [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006191#pgen.1006191.ref057" target="_blank">57</a>]. GO terms with adjusted P-values <0.001 are presented. There is no enriched GO term for type I editing events.</p
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