879 research outputs found
A trade-off between cognitive and physical performance, with relative preservation of brain function
Debate surrounds the issue of how the large, metabolically expensive brains of Homo sapiens can be energetically afforded. At the evolutionary level, decreased investment in muscularity, adiposity and the digestive tract allow for a larger brain. Developmentally, high neo-natal adiposity and preferential distribution of resources to the brain provide an energetic buffer during times of environmental stress. Through an experimental design, we investigated the hypothesis of a trade-off involving brain and muscle at the acute level in humans. Mental performance was measured by a free-recall test, and physical performance by power output on an indoor rowing ergometer. Sixty-two male student rowers performed the two tests in isolation, and then again simultaneously. Paired samples t-tests revealed that both power output and mental performance reduced when tested together compared to in isolation (t(61) = 9.699, p < 0.001 and t(61) = 8.975, p < 0.001). Furthermore, the decrease in physical performance was greater than the decrease in mental performance (t(61) = −2.069, p = 0.043). This is the first investigation to demonstrate an acute level trade-off between these two functions, and provides support for the selfish brain hypothesis due to the relative preservation of cognitive function over physical power output. The underlying mechanism is unclear, and requires further work
Oil Spill Segmentation in Fused Synthetic Aperture Radar Images
Synthetic Aperture Radar (SAR) satellite systems are very efficient in oil spill monitoring due to their capability to operate under all weather conditions. Systems such as the Envisat and RADARSAT have been used independently in many studies to detect oil spill. This paper presents an automatic feature based image registration and fusion algorithm for oil spill monitoring using SAR images. A range of metrics are used to evaluate the performance of the algorithm and to demonstrate the benefits of fusing SAR images of different modalities. The proposed framework has shown 45% improvement of the oil spill location when compared with the individual images before the fusio
The historic built environment as a long-term geochemical archive: telling the time on the urban “pollution clock”
This study introduces a novel methodology for utilizing historic built environments as reliable long-term geochemical archives, addressing a gap in the reconstruction of past anthropogenic pollution levels in urban settings. For the first time, we employ high-resolution laser ablation mass spectrometry for lead isotope (206Pb/207Pb and 208Pb/206Pb) analysis on 350-year-old black crust stratigraphies found on historic built structures, providing insights into past air pollution signatures. Our findings reveal a gradual shift in the crust stratigraphy toward lower 206Pb/207Pb and higher 208Pb/206Pb isotope ratios from the older to the younger layers, indicating changes in lead sources over time. Mass balance analysis of the isotope data shows black crust layers formed since 1669 primarily contain over 90% Pb from coal burning, while other lead sources from a set of modern pollution including but not limited to leaded gasoline (introduced after 1920) become dominant (up to 60%) from 1875 onward. In contrast to global archives such as ice cores that provide integrated signals of long-distance pollution, our study contributes to a deeper understanding of localized pollution levels, specifically in urban settings. Our approach complements multiple sources of evidence, enhancing our understanding of air pollution dynamics and trends, and the impact of human activities on urban environments
Alternative Metabolic Strategies are Employed by Endurance Runners of Different Body Sizes; Implications for Human Evolution
OBJECTIVE:
A suite of adaptations facilitating endurance running (ER) evolved within the hominin lineage. This may have improved our ability to reach scavenging sites before competitors, or to hunt prey over long distances. Running economy (RE) is a key determinant of endurance running performance, and depends largely on the magnitude of force required to support body mass. However, numerous environmental factors influence body mass, thereby significantly affecting RE. This study tested the hypothesis that alternative metabolic strategies may have emerged to enable ER in individuals with larger body mass and poor RE.
METHODS:
A cohort of male (n = 25) and female (n = 19) ultra-endurance runners completed submaximal and exhaustive treadmill protocols to determine RE, and V̇O2Max.
RESULTS:
Body mass was positively associated with sub-maximal oxygen consumption at both LT1 (male r=0.66, p<0.001; female LT1 r=0.23, p=0.177) and LT2 (male r=0.59, p=0.001; female r=0.23, p=0.183) and also with V̇O2Max (male r=0.60, p=0.001; female r=0.41, p=0.046). Additionally, sub-maximal oxygen consumption varied positively with V̇O2Max in both male (LT1 r=0.54, p=0.003; LT2 r=0.77, p<0.001) and female athletes (LT1 r=0.88, p<0.001; LT2 r=0.92, p<0.001).
CONCLUSIONS:
The results suggest that, while individuals with low mass and good RE can glide economically as they run, larger individuals can compensate for the negative effects their mass has on RE by increasing their capacity to consume oxygen. The elevated energy expenditure of this low-economy high-energy turnover approach to ER may bring costs associated with energy diversion away from other physiological processes, however
Semiclassical Quantization by Pade Approximant to Periodic Orbit Sums
Periodic orbit quantization requires an analytic continuation of
non-convergent semiclassical trace formulae. We propose a method for
semiclassical quantization based upon the Pade approximant to the periodic
orbit sums. The Pade approximant allows the re-summation of the typically
exponentially divergent periodic orbit terms. The technique does not depend on
the existence of a symbolic dynamics and can be applied to both bound and open
systems. Numerical results are presented for two different systems with chaotic
and regular classical dynamics, viz. the three-disk scattering system and the
circle billiard.Comment: 7 pages, 3 figures, submitted to Europhys. Let
Collisionless shock acceleration of narrow energy spread ion beams from mixed species plasmas using 1 m lasers
Collisionless shock acceleration of protons and C ions has been
achieved by the interaction of a 10 W/cm, 1 m laser with a
near-critical density plasma. Ablation of the initially solid density target by
a secondary laser allowed for systematic control of the plasma profile. This
enabled the production of beams with peaked spectra with energies of 10-18
MeV/a.m.u. and energy spreads of 10-20 with up to 3x10 particles within
these narrow spectral features. The narrow energy spread and similar velocity
of ion species with different charge-to-mass ratio are consistent with
acceleration by the moving potential of a shock wave. Particle-in-cell
simulations show shock accelerated beams of protons and C ions with
energy distributions consistent with the experiments. Simulations further
indicate the plasma profile determines the trade-off between the beam charge
and energy and that with additional target optimization narrow energy spread
beams exceeding 100 MeV/a.m.u. can be produced using the same laser conditions.Comment: Accepted for publication in Physical Review Accelerators and Beam
Study of Foaming Properties and Effect of the Isomeric Distribution of Some Anionic Surfactants
Using different reaction conditions of photosulfochlorination of n-dodecane, two samples of anionic surfactants of sulfonate type are obtained. Their micellar behavior has been already reported and the relationship between their isomeric distribution and their chemical structures and micellar behaviors have been more thoroughly explored. In this investigation, we screened the foaming properties (foaming power and foam stability) by a standardized method very similar to the Ross–Miles foaming tests to identify which surfactants are suitable for applications requiring high foaming, or, alternatively, low foaming. The results obtained for the synthesized surfactants are compared to those obtained for an industrial sample of secondary alkanesulfonate (Hostapur 60) and to those of a commercial sample of sodium dodecylsulfate used as reference for anionic surfactants. The foam formation and foam stability of aqueous solutions of the two samples of dodecanesulfonate are compared as a function of their isomeric distribution. These compounds show good foaming power characterized in most cases by metastable or dry foams. The highest foaming power is obtained for the sample rich in primary isomers which also produces foam with a relatively high stability. For the sample rich in secondary isomers we observe under fixed conditions a comparable initial foam height but the foam stability turns out to be low. This property is interesting for applications requiring low foaming properties such as dishwashing liquid for machines. The best results are observed near and above the critical micellar concentrations and at 25 C for both the samples
Compound heterozygous variants in NBAS as a cause of atypical osteogenesis imperfecta
Background
Osteogenesis imperfecta (OI), the commonest inherited bone fragility disorder, affects 1 in 15,000 live births resulting in frequent fractures and reduced mobility, with significant impact on quality of life. Early diagnosis is important, as therapeutic advances can lead to improved clinical outcome and patient benefit.
Report
Whole exome sequencing in patients with OI identified, in two patients with a multi-system phenotype, compound heterozygous variants in NBAS (neuroblastoma amplified sequence). Patient 1: NBAS c.5741G > A p.(Arg1914His); c.3010C > T p.(Arg1004*) in a 10-year old boy with significant short stature, bone fragility requiring treatment with bisphosphonates, developmental delay and immunodeficiency. Patient 2: NBAS c.5741G > A p.(Arg1914His); c.2032C > T p.(Gln678*) in a 5-year old boy with similar presenting features, bone fragility, mild developmental delay, abnormal liver function tests and immunodeficiency.
Discussion
Homozygous missense NBAS variants cause SOPH syndrome (short stature; optic atrophy; Pelger-Huet anomaly), the same missense variant was found in our patients on one allele and a nonsense variant in the other allele. Recent literature suggests a multi-system phenotype. In this study, patient fibroblasts have shown reduced collagen expression, compared to control cells and RNAseq studies, in bone cells show that NBAS is expressed in osteoblasts and osteocytes of rodents and primates. These findings provide proof-of-concept that NBAS mutations have mechanistic effects in bone, and that NBAS variants are a novel cause of bone fragility, which is distinguishable from ‘Classical’ OI.
Conclusions
Here we report on variants in NBAS, as a cause of bone fragility in humans, and expand the phenotypic spectrum associated with NBAS. We explore the mechanism underlying NBAS and the striking skeletal phenotype in our patients
- …