The regions having significantly increased MD values in the aMCI group compared to the control group (TFCE corrected, p<0.05).

<p>The regions having significantly increased MD values in the aMCI group compared to the control group (TFCE corrected, p<0.05).</p

Demographic Characteristics of both groups.

<p>Demographic Characteristics of both groups.</p

The anatomical areas that showed significantly reduced FAvalues in aMCI compared to normal controls (TFCE- corrected, p<0.0001).

<p>The anatomical areas that showed significantly reduced FAvalues in aMCI compared to normal controls (TFCE- corrected, p<0.0001).</p

The regions having significantly increased MD values in the aMCI group compared to the control group (TFCE corrected, p<0.0001).

<p>The regions having significantly increased MD values in the aMCI group compared to the control group (TFCE corrected, p<0.0001).</p

The anatomical regions that showed significantly increased MD values in aMCI compared to normal controls (TCFE-corrected, p<0.0001).

<p>The anatomical regions that showed significantly increased MD values in aMCI compared to normal controls (TCFE-corrected, p<0.0001).</p

The regions having significantly reduced FA values in the aMCI group compared to the control group (TFCE corrected, p<0.0001).

<p>The regions having significantly reduced FA values in the aMCI group compared to the control group (TFCE corrected, p<0.0001).</p

Cortical (A) and subcortical (B) GM volume loss in svMCI.

<p>The svMCI patients showed decreased GM volume in several frontal, temporal, occipital and subcortical brain regions. For the details, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044758#pone-0044758-t002" target="_blank">Table 2</a>. The statistical threshold was set at P<0.01 for individual voxels and cluster size >948 mm³, which corresponded to a corrected P<0.01 determined by Monte Carlo simulations. Cortical (A) t statistical maps were rendered by using the BrainNet Viewer (<a href="http://www.nitrc.org/projects/bnv/" target="_blank">http://www.nitrc.org/projects/bnv/</a>). Subcortical (B) t statistical map was overlaid on a single anatomical image (i.e., ch2bet.nii) provided in the MRIcroN software (<a href="http://www.cabiatl.com/mricro/" target="_blank">http://www.cabiatl.com/mricro/</a>). R, right; L, left.</p

Between-group differences in functional connectivity density without (A) and with (B) correcting GM volume.

<p>The svMCI patients showed decreased functional connectivity density in frontal, temporal and parietal regions. Of note, several brain regions which showed functional connectivity density reduction were not significant after GM correction. The statistical threshold was set at P<0.01 for individual voxels and cluster size >972 mm³, which corresponded to a corrected P<0.01 determined by Monte Carlo simulations. The t statistical maps were rendered by using the BrainNet Viewer (<a href="http://www.nitrc.org/projects/bnv/" target="_blank">http://www.nitrc.org/projects/bnv/</a>).R, right; L, left.</p

Regions showing GM volume atrophy in the svMCI patients.

<p>BA, Brodmann area; Vol, cluster volume; X, Y, Z, coordinates of peak locations; T, t statistical value at peak locations. STG, superior temporal gyrus; ITG, inferior temporal gyrus; CAU, caudate; THA, thalamus; MOG, middle occipital gyrus; IPL, inferior parietal lobule; SFG, superior frontal gyrus; MFG, middle frontal gyrus.</p

Within-group functional connectivity maps of the HC (left) and svMCI (right) groups.

<p>Widely spread regions of parietal, frontal, occipital and temporal lobes exhibited high functional connectivity values in the both groups. Note that the posterior cingulate (PCC) and adjacent precuneus (PCu) showed the highest functional connectivity density in the both groups. The statistical threshold was set at P<0.001 for individual voxels and cluster size >324 mm³, which corresponded to a corrected P<0.01 determined by Monte Carlo simulations. L, left; R, right; P, posterior; A, anterior.</p