Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Co-operation and the 'new consumerism' in interwar England

Economic historians have recently taught us a great deal about the 'new consumerism' in interwar Britain. However, the story has largely been told from the supply side and the Co-operative movement that played a key role in the lives of millions of working-class consumers has tended to be marginalised. This article brings the movement and the consumer centre stage. First, the uneven and vulnerable situation of the Co-op as a business is outlined. The next section briefly sketches economic and political attacks on the movement that made it more difficult to respond effectively to the challenges it faced. The major part of the article discusses oral evidence from ordinary co-operative members, which helps illuminate the contradictory pressures faced by consumers in this period. © 2012 Copyright Taylor and Francis Group, LLC