Local businesses : an overlooked asset during rapid growth

Booming cities often experience a rapidly growing economy coupled with issues of inequality. With skyrocketing costs of living and displacement of long time residents, housing gentrification is a common topic of debate for growing cities, but local business displacement is often left out of the equity discussion. Small, local businesses struggle with similar challenges as individuals during affordability crises, and are similarly priced out of neighborhoods where they have had a long-standing community presence. Research shows that local businesses provide lasting benefits to cities and represent a sustainable solution to many affordability issues. In order to retain these benefits, state and local governments need to shift economic development policy from traditional efforts of business attraction to policies that thoroughly address issues of local business displacement. Worldwide trends, such as the mobility of labor and the globalization of capital, will affect cities, especially as non-local sources of revenue continue to shrink. Cities can look to local businesses to provide economic stability and to help differentiate themselves as they compete nationally and globally for residents and investment.Community and Regional Plannin

Characterization of Mmp37p, a \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e Mitochondrial Matrix Protein with a Role in Mitochondrial Protein Import

Many mitochondrial proteins are encoded by nuclear genes and after translation in the cytoplasm are imported via translocases in the outer and inner membranes, the TOM and TIM complexes, respectively. Here, we report the characterization of the mitochondrial protein, Mmp37p (YGR046w) and demonstrate its involvement in the process of protein import into mitochondria. Haploid cells deleted of MMP37 are viable but display a temperature-sensitive growth phenotype and are inviable in the absence of mitochondrial DNA. Mmp37p is located in the mitochondrial matrix where it is peripherally associated with the inner membrane. We show that Mmp37p has a role in the translocation of proteins across the mitochondrial inner membrane via the TIM23-PAM complex and further demonstrate that substrates containing a tightly folded domain in close proximity to their mitochondrial targeting sequences display a particular dependency on Mmp37p for mitochondrial import. Prior unfolding of the preprotein, or extension of the region between the targeting signal and the tightly folded domain, relieves their dependency for Mmp37p. Furthermore, evidence is presented to show that Mmp37 may affect the assembly state of the TIM23 complex. On the basis of these findings, we hypothesize that the presence of Mmp37p enhances the early stages of the TIM23 matrix import pathway to ensure engagement of incoming preproteins with the mtHsp70p/PAM complex, a step that is necessary to drive the unfolding and complete translocation of the preprotein into the matrix

I have a Dream Act

With election season just behind us and Obama re-elected for a second term, change is in the air. One change has the potential to affect more than 1.4 million people living in the United States. This group of individuals is the US population of undocumented persons, often incorrectly referred to as “illegal immigrants.” Laws, acts, bills, and amendments to change the situation of these persons have been discussed for decades, but there is one that might actually stick. Pitched to Congress in 2001, the Development, Relief, and Education for Alien Minors (DREAM) act gave immigrants hope for a better life

Change in parental and peer relationship quality during emerging adulthood Implications for academic, social, and emotional functioning [post-print]

We report on two longitudinal studies, where we examined how stability and change in attachment to parents and peers from the first to last year of college were associated with changes in theoretically relevant outcomes. As expected, students with consistently secure parental and peer attachment evidenced the best academic, social, and emotional functioning overall. Participants with “stable secure” parental attachment reported significant increases in their academic and emotional functioning and their social competencies; on the other hand, students with consistently low parental attachment showed a decline in their emotional functioning. Participants with stable secure peer attachment also reported lower overall levels of depression and loneliness, better social competence, and more favorable attitudes about help-seeking. Finally, students who transitioned from lower to higher parental attachment showed significant declines in loneliness; those transitioning from low to high peer attachment evidenced a significant increase in social functioning. We discuss implications for how college-based programming might serve to forestall declines in parental/peer attachment and/or facilitate skill building among students who identify with a more insecure style at college entry

Employer Health Benefits 2016 Annual Survey

This annual survey of employers provides a detailed look at trends in employer-sponsored health coverage including premiums, employee contributions, cost-sharing provisions, and employer opinions. The 2016 survey included almost 1,900 interviews with non-federal public and private firms.Annual premiums for employer-sponsored family health coverage reached $18,142 this year, up 3 percent from last year, with workers on average paying$5,277 towards the cost of their coverage, according to the Kaiser Family Foundation/Health Research & Education Trust 2016 Employer Health Benefits Survey. The 2016 survey includes information on the use of incentives for employer wellness programs, plan cost-sharing as well as firm offer rate. Survey results are released here in a variety of ways, including a full report with downloadable tables on a variety of topics, summary of findings, and an article published in the journal Health Affairs