Error-analysis and comparison to analytical models of numerical waveforms produced by the NRAR Collaboration

The Numerical-Relativity-Analytical-Relativity (NRAR) collaboration is a joint effort between members of the numerical relativity, analytical relativity and gravitational-wave data analysis communities. The goal of the NRAR collaboration is to produce numerical-relativity simulations of compact binaries and use them to develop accurate analytical templates for the LIGO/Virgo Collaboration to use in detecting gravitational-wave signals and extracting astrophysical information from them. We describe the results of the first stage of the NRAR project, which focused on producing an initial set of numerical waveforms from binary black holes with moderate mass ratios and spins, as well as one non-spinning binary configuration which has a mass ratio of 10. All of the numerical waveforms are analysed in a uniform and consistent manner, with numerical errors evaluated using an analysis code created by members of the NRAR collaboration. We compare previously-calibrated, non-precessing analytical waveforms, notably the effective-one-body (EOB) and phenomenological template families, to the newly-produced numerical waveforms. We find that when the binary's total mass is ~100-200 solar masses, current EOB and phenomenological models of spinning, non-precessing binary waveforms have overlaps above 99% (for advanced LIGO) with all of the non-precessing-binary numerical waveforms with mass ratios <= 4, when maximizing over binary parameters. This implies that the loss of event rate due to modelling error is below 3%. Moreover, the non-spinning EOB waveforms previously calibrated to five non-spinning waveforms with mass ratio smaller than 6 have overlaps above 99.7% with the numerical waveform with a mass ratio of 10, without even maximizing on the binary parameters.Comment: 51 pages, 10 figures; published versio

Empirical tests of the black hole no-hair conjecture using gravitational-wave observations

We show that second-generation gravitational-wave detectors at their design sensitivity will allow us to directly probe the ringdown phase of binary black hole coalescences. This opens the possibility to test the so-called black hole no-hair conjecture in a statistically rigorous way. Using state-of-the-art numerical relativity-tuned waveform models and dedicated methods to effectively isolate the quasistationary perturbative regime where a ringdown description is valid, we demonstrate the capability of measuring the physical parameters of the remnant black hole and subsequently determining parameterized deviations from the ringdown of Kerr black holes. By combining information from O(5) binary black hole mergers with realistic signal-to-noise ratios achievable with the current generation of detectors, the validity of the no-hair conjecture can be verified with an accuracy of similar to 1.5% at 90% confidence

The NINJA-2 catalog of hybrid post-Newtonian/numerical-relativity waveforms for non-precessing black-hole binaries

The numerical injection analysis (NINJA) project is a collaborative effort between members of the numerical-relativity and gravitational wave data-analysis communities. The purpose of NINJA is to study the sensitivity of existing gravitational-wave search and parameter-estimation algorithms using numerically generated waveforms and to foster closer collaboration between the numerical-relativity and data-analysis communities. The first NINJA project used only a small number of injections of short numerical-relativity waveforms, which limited its ability to draw quantitative conclusions. The goal of the NINJA-2 project is to overcome these limitations with long post-Newtonian—numerical-relativity hybrid waveforms, large numbers of injections and the use of real detector data. We report on the submission requirements for the NINJA-2 project and the construction of the waveform catalog. Eight numerical-relativity groups have contributed 56 hybrid waveforms consisting of a numerical portion modeling the late inspiral, merger and ringdown stitched to a post-Newtonian portion modeling the early inspiral. We summarize the techniques used by each group in constructing their submissions. We also report on the procedures used to validate these submissions, including examination in the time and frequency domains and comparisons of waveforms from different groups against each other. These procedures have so far considered only the (ℓ, m) = (2, 2) mode. Based on these studies, we judge that the hybrid waveforms are suitable for NINJA-2 studies. We note some of the plans for these investigations

Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1)

Congenital fibrosis of the extraocular muscles type 1 (CFEOM1; OMIM #135700) is an autosomal dominant strabismus disorder associated with defects of the oculomotor nerve. We show that individuals with CFEOM1 harbor heterozygous missense mutations in a kinesin motor protein encoded by KIF21A. We identified six different mutations in 44 of 45 probands. The primary mutational hotspots are in the stalk domain, highlighting an important new role for KIF21A and its stalk in the formation of the oculomotor axis

Animal models of nonalcoholic fatty liver disease

In 1980, Ludwig and colleagues described a series of patients with liver histology characterized by the accumulation of fat and the presence of hepatic necroinflammation in the absence of a history of excessive alcohol consumption. They coined the term nonalcoholic steatohepatitis (NASH), which today is regarded as one of the most common causes of liver disease in affluent countries. NASH is a subset of a larger spectrum of diseases termed fatty liver disease (including alcoholic and nonalcoholic fatty liver disease; AFLD and NAFLD, respectively). NAFLD and NASH are linked to visceral adiposity, insulin resistance, dyslipidemia and type 2 diabetes, and are increasing due to the prevalence of the metabolic syndrome. In this context, research has been undertaken using animals to model human steatosis and NAFLD to NASH disease progression. This Review discusses the prevalent dietary and inflammation-based genetic animal models described in recent years

The second book of the Rhymers' Club.

Mode of access: Internet.Clark Library copy 3: inscribed by Ernest Radford to his wife, dated June 24, 1894.Clark Library copy 2: 5 p.l., [xiii]-xvi, 136 p.; first ed., large paper copy; 'fifty copies have been printed for England, and twenty copies for America"; without advertisements; bookplate of Albert Parsons Sachs.Clark Library copy 1: 5 p.l., [xiii]-xvi, 136 p.; first edition, small paper copy; "Five hundred copies have been printed for England (of which four hundred only are for sale). One hundred and fifty copies also have been printed for America"; advertisements, 14, [1] p., bound at end; autograph presentation copy from Ernest Christopher Dowson to Alexander Teixeira de Mattos; armorial bookplate of Alexander Teixeira de Mattos.Clark Library has 3 copies, one of which is the large paper copy