Limited-stage small-cell lung cancer : current progress and the next frontier

Limited-stage (LS) small-cell lung cancer (SCLC) is defined as disease confined to a tolerable radiation portal without extrathoracic metastases. Despite clinical research over two decades, the prognosis of LS-SCLC patients remains poor. The current standard of care for LS-SCLC patients is concurrent platinum-based chemotherapy with thoracic radiotherapy (RT). Widespread heterogeneity on the optimal radiation dose and fractionation regimen among physicians highlights the logistical challenges of administering BID regimens. Prophylactic cranial irradiation (PCI) is recommended to patients following a good initial response to chemoradiation due to improved overall survival from historical trials and the propensity for LS-SCLC to recur with brain metastases. However, PCI utilization is being debated due to the greater availability of magnetic resonance imaging (MRI) and data in extensive-stage SCLC regarding close MRI surveillance in lieu of PCI while spurring novel RT techniques, such as hippocampal-avoidance PCI. Additionally, novel treatment combinations incorporating targeted small molecule therapies and immunotherapies with or following radiation for LS-SCLC have seen recent interest and some concepts are being investigated in clinical trials. Here, we review the landscape of progress, limitations, and challenges for LS-SCLC including current standard of care, novel radiation techniques, and the integration of novel therapeutic strategies for LS-SCLC

Impact response of steel fiber-reinforced concrete using a split Hopkinson pressure bar

10.1061/(ASCE)0899-1561(2004)16:1(54)Journal of Materials in Civil Engineering16154-5

Soft tissue strain measurement using an optical method

10.1117/12.839336Proceedings of SPIE - The International Society for Optical Engineering7375-PSIS

Design of unbraced multi-storey steel frames

SIGLEAvailable from British Library Lending Division - LD:D56591/85 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

New methodology for mechanical characterisation of solders for IC packaging

Advances in Electronic Packaging1551-55

Contact pressure measurement using silicon-based AlxGa 1-xAs semiconductor pressure sensors

10.1016/j.sna.2004.07.012Sensors and Actuators, A: Physical1182190-201SAAP

An efficient method of estimating the true value of a population characteristic from its discrepant estimates

A fruitful method of pooling data from disparate sources, such as a set of sample surveys, is developed. This method proceeds by finding the first two moments of two conditional distributions derived from a joint distribution of two sample estimators of employment for each of several geographical areas. The nature of the two estimators is such that one of them can yield a better estimate of national employment than the other. The regression of the former estimator on the latter estimator with stochastic intercept and slope is used to generate an improved estimator that is equal to bias- and error-corrected estimator for each area with probability 1. This analysis is extended to cases where more than two estimates of employment are available for each area.