A Graph-Partition-Based Scheduling Policy for Heterogeneous Architectures

In order to improve system performance efficiently, a number of systems choose to equip multi-core and many-core processors (such as GPUs). Due to their discrete memory these heterogeneous architectures comprise a distributed system within a computer. A data-flow programming model is attractive in this setting for its ease of expressing concurrency. Programmers only need to define task dependencies without considering how to schedule them on the hardware. However, mapping the resulting task graph onto hardware efficiently remains a challenge. In this paper, we propose a graph-partition scheduling policy for mapping data-flow workloads to heterogeneous hardware. According to our experiments, our graph-partition-based scheduling achieves comparable performance to conventional queue-base approaches.Comment: Presented at DATE Friday Workshop on Heterogeneous Architectures and Design Methods for Embedded Image Systems (HIS 2015) (arXiv:1502.07241

Posttranslational modifications of Ancient Ubiquitous Protein 1 control intracellular Lipid Droplet clustering

Lipid droplets (LDs) are the intracellular storage organelles for neutral lipids. Over the last decade LDs have been identified to play important roles in lipid homeostasis, cellular signaling events and as a platform to sequester specific proteins. Lipid droplets are also linked to human diseases like type 2 diabetes or obesity. LDs are dynamic organelles, which can move rapidly within cells along microtubule tracks using the cellular transport machinery. While LDs are usually found evenly dispersed throughout the cytoplasm of cells, they have also been observed to aggregate and form dense clusters consisting of numerous individual LDs. It has been suggested that LD clustering is involved in LD fusion or in mediating increased storage of neutral lipids. Even though several proteins have been shown to induce LD clustering, a molecular mechanism explaining how LDs are tethered to form these clusters is unknown. This thesis demonstrates that LD associated ancient ubiquitous protein 1 (AUP1) promotes the clustering of LDs. Furthermore, it is shown that knock-down of AUP1 leads to the dispersion of LD clusters. Results from this study demonstrate that AUP1 is ubiquitinated in a process that depends on the integrity of an intrinsic AUP1 ubiquitin-binding domain. It is also shown that AUP1 is ubiquitinated at several lysine residues. AUP1 mutants that fail to become ubiquitinated lose the ability to promote LD clustering. Fusing a single ubiquitin moiety to AUP1 mutants that otherwise fail to induce LD clustering, is sufficient to restore LD clustering in cells. Thus, for the first time a posttranslational modification is identified that controls the clustering of LDs. In addition, AUP1 is known to be a highly phosphorylated protein and this study shows that mimicking phosphorylation of one specific threonine residue attenuates AUP1-induced LD clustering. It further shows that this phosphorylation of AUP1 does not interfere with the ubiquitination of AUP1. Based on these findings, a regulatory mechanism is proposed in which the identified posttranslational modifications of AUP1 control intracellular LD clustering

The Verseidag Silk Factory in Krefeld. Architectural History and Restoration of a much-neglected Mies van der Rohe Project

Although the buildings for the Verseidag silk factory, in Krefeld, Germany, are the only factory buildings that Mies van der Rohe ever planned and built (1931-38), many open questions remain about the history and development of the site. The paper presents new research results on the architectural history and materiality of the site that are derived from detailed documentation on site and analysis of newly available archive material. The scientific results and the acquired knowledge directly influence the current restoration of the buildings, in which the key characteristics designed by Mies van der Rohe are preserved and restored

“Zur Neuen Welt” — Towards the New World. Ludwig Mies and his Architectural Youth in Aachen

Ludwig Mies van der Rohe's personal and professional connections to his hometown Aachen in Germany are mostly unknown today. Through the analysis of both old and new written and graphic sources, the authors give an insight into Mies van der Rohe's lifelong bond to his hometown. In the personal friendships, his friends Ferdinand Goebbels and Franz Dominick play a key role. Furthermore, the paper presents previously unknown buildings that young Mies was working on in the office of Albert Schneiders around 1905. One of the buildings, the house “Zur Neuen Welt” for client Joseph Oeben, is still standing and represents a lively example of the stylistic search in architecture after the turn of the millennium, and an early step towards Mies van der Rohe's architectural maturity

Master Plans and Deviations. Mies van der Rohe's involvement in urban development at Verseidag Krefeld and IIT Chicago

In the few written sources about Mies van der Rohe’s Krefeld silk factory, Verseidag (1930–1938), the urban layout and building design have been repeatedly compared with his Campus master plan for the Illinois Institute of Technology in Chicago (IIT) (1939–41). New research based on rediscovered plan material from Krefeld allow for a detailed description of the historic development of the Verseidag plant, including the identification of master plans, later deviations and their abandonment. With this knowledge, a substantial comparison of the two projects may be established that shows surprisingly strong parallels both in their urban form and their later transformations

Emerging perspectives on post-conflict police-community relations II

he world is increasingly interconnected - insecurity in one country can both directly and indirectly affect the security of people, countries and regions that are far away. Therefore, when conflict erupts in one part of the world, the international community responds in various ways to mitigate its effects, both locally and internationally. Whether it be through the provision of police, military and/or civilian personnel, humanitarian assistance, or post-conflict development assistance, the international community has repeatedly attempted to mitigate the effects of conflict, as well as to contribute to reforms which might lead to the prevention of local and global insecurity in the future. This Special Issue is dedicated to exploring community-oriented policing (COP) and police reform in a series of post-conflict contexts: Kosovo, Guatemala, Afghanistan, Pakistan, Somalia and Kenya. The papers are based on mixed-methods research conducted under the EU-funded project "Community-Oriented Policing and Post-Conflict Police Reform" (ICT4COP 2015-2020). In this project, and in the papers in this special issue, we explore how police reform in volatile contexts has taken place, and whether a focus on COP approaches rather than militarized approaches might be more effective in building trust, preventing violence and ensuring human security