Two responses of a uniformly stratified flow over a sloping bottom to a spatially varying downwelling favorable wind

Submitted in partial fulfillment of the requirements for the degree of Master of Science at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution September 2008The work was motivated by studies of Austin and Lentz (2002) and Pedlosky (2007). The above mentioned works considered two different responses of the stratified flow to a downwelling favorable wind forcing. The first study investigated a time dependent flow with a formation of a constantly expanding relatively well mixed region near the shore and the second considered a steady flow that arises when an offshore varying wind is applied. In my thesis I use ROMS to determine which type of response will take place based on the wind amplitude near the coast. It was demonstrated that if the value of the wind is much smaller than the critical value (determined by the stratification, the rotation rate and the horizontal diffusivity) then the flow is steady (the bbl case) and similar to the one investigated by Pedlosky. If the wind is of the order, or larger than, the critical value then the response is time dependent (the pool case) and similar to the one described by Austin and Lentz. The resulting flow structure of each response was also investigated. I examined the sensitivity of the bbl response to variations in the background vertical diffusivity, the initial stratification and the bottom slope. It was shown that a higher background vertical diffusivity, a higher stratification and a shallower bottom slope correspond to thinner (vertically) and narrower (horizontally) bbl. For the pool case the time dependent structure was also examined, using a number of idealized models. It was shown that the rate of the pool region expansion is a complex function of the local wind stress amplitude and the local depth

CHEK2 1100 delC mutation in Russian ovarian cancer patients

BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients. The mutation was identified in 2 women with OC (0.8%) as compared to 1/448 (0.2%) healthy middle-aged and 0/373 elderly tumour-free women. Taken together this result and the negative findings of two other published reports on an association of CHEK2 with ovarian cancer indicate that there is no justification for intensive ovarian cancer screening in CHEK2 1100 delC carriers

CHEK2 1100 delC mutation in Russian ovarian cancer patients

Abstract BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients. The mutation was identified in 2 women with OC (0.8%) as compared to 1/448 (0.2%) healthy middle-aged and 0/373 elderly tumour-free women. Taken together this result and the negative findings of two other published reports on an association of CHEK2 with ovarian cancer indicate that there is no justification for intensive ovarian cancer screening in CHEK2 1100 delC carriers.</p