北海道とフィンランドのサルコイドーシス : 比較研究の結果

Two comparative Finnish-Japanese sarcoidosis studies were carried out. One study compared the frequencies of sarcoidosis in 1984 in Hokkaido and Finland. We found a significantly and approximately four times higher prevalence and incidence of sarcoidosis in Finland than in Hok kaido ; prevalence 28.2/100,000 in Finland and 7.2/100,000 in Hokkaido ; incidence ll.4/100,000 in Fin land and 2.8/100,000 in Hokkaido, The other study compared the clinical picture and prognosis of sarcoidosis in two large hospital series ; 686 patients in Sapporo and 571 patients in Mjolbolsta, Fin land. The sex ratio was the same with a slight female predominance in both hospitals. The Japanese patients were younger at the time of diagnosis (mean age 30 years in Sapporo compared with 42 years in Mjolbolsta), although 50% of the patients in both series had been detected via rou tine health screening procedures. Among the symptomatic patients the mode of presentation of the disease varied considerably with eye symptoms as the dominating in Sapporo, but with respiratory symptoms and Lofgren\u27s syndrome in Finland. Stage I disease was more frequent in Sapporo, (57% of the patients compared with 48% in Finland) whereas more Finnish patients had parenchymal lesions. Extrapulmonary manifestations of sarcoidosis were more often diagnosed in Sapporo ; main ly because of the eye lesions. The prognosis of pulmonary sarcoidosis in Finland was significantly less favourable than the prognosis of the Japanese patients