Higher education learning framework: an evidence informed model for university learning

Learning as a developmental process is the central consideration of effective higher education. Grounded on a synthesis of existing frameworks, literature, and research on the topic, the Higher Education Learning Framework (HELF) was informed by interviews with national and international experts in learning and higher education offering the latest thinking on university learning. A science of learning lens was applied during development, threading together the often-disparate thinking in education, neuroscience, and psychology, to offer a convergent framework on effective learning in higher education. This unprecedented approach to understanding learning in a tertiary context provides a robust framework that can broadly guide the higher education sector

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

The Higher Education Learning Framework:\ua0an evidence-informed model for\ua0university learning

This project aimed to develop an evidence-informed model for university learning in the form of a Higher Education Learning Framework (HELF). This was achieved through a synthesis of existing frameworks, literature, and research on the topic along with a set of national and international expert interviews offering the latest thinking on university learning. This framework has been developed through a Science of Learning lens that threads together the often disparate thinking in education, neuroscience, and psychology to offer a convergent framework on effective learning in higher education that can broadly guide the higher education sector. The HELF Matrix is a 1 page overview outlining the Teacher, Student, and Assessment implications of the of the HELF Principles