Neural Poisson Surface Reconstruction: Resolution-Agnostic Shape Reconstruction from Point Clouds

We introduce Neural Poisson Surface Reconstruction (nPSR), an architecture for shape reconstruction that addresses the challenge of recovering 3D shapes from points. Traditional deep neural networks face challenges with common 3D shape discretization techniques due to their computational complexity at higher resolutions. To overcome this, we leverage Fourier Neural Operators to solve the Poisson equation and reconstruct a mesh from oriented point cloud measurements. nPSR exhibits two main advantages: First, it enables efficient training on low-resolution data while achieving comparable performance at high-resolution evaluation, thanks to the resolution-agnostic nature of FNOs. This feature allows for one-shot super-resolution. Second, our method surpasses existing approaches in reconstruction quality while being differentiable and robust with respect to point sampling rates. Overall, the neural Poisson surface reconstruction not only improves upon the limitations of classical deep neural networks in shape reconstruction but also achieves superior results in terms of reconstruction quality, running time, and resolution agnosticism

Inhibición de la percepción de quórum de Pseudomonas aeruginosa y atenuación de la virulencia en aislados clínicos.

La percepción de quórum de Pseudomonas aeruginosa regula la producción de múltiples factores de virulencia en esta bacteria responsable del 10% de infecciones intrahospitalarias. En el presente trabajo se discutirán diferentes estrategias para bloquearla con el objetivo de atenuar la virulencia en cepas multidrogo resistentes

Seeding Public Goods Is Essential for Maintaining Cooperation in Pseudomonas aeruginosa

Quorum sensing in Pseudomonas aeruginosa controls the production of costly public goods such as exoproteases. This cooperative behavior is susceptible to social cheating by mutants that do not invest in the exoprotease production but assimilate the amino acids and peptides derived by the hydrolysis of proteins in the extracellular media. In sequential cultures with protein as the sole carbon source, these social cheaters are readily selected and often reach equilibrium with the exoprotease producers. Nevertheless, an excess of cheaters causes the collapse of population growth. In this work, using the reference strain PA14 and a clinical isolate from a burn patient, we demonstrate that the initial amount of public goods (exoprotease) that comes with the inoculum in each sequential culture is essential for maintaining population growth and that eliminating the exoprotease in the inoculum leads to rapid population collapse. Therefore, our results suggest that sequential washes should be combined with public good inhibitors to more effectively combat P. aeruginosa infections

Seeding Public Goods Is Essential for Maintaining Cooperation in Pseudomonas aeruginosa

Quorum sensing in Pseudomonas aeruginosa controls the production of costly public goods such as exoproteases. This cooperative behavior is susceptible to social cheating by mutants that do not invest in the exoprotease production but assimilate the amino acids and peptides derived by the hydrolysis of proteins in the extracellular media. In sequential cultures with protein as the sole carbon source, these social cheaters are readily selected and often reach equilibrium with the exoprotease producers. Nevertheless, an excess of cheaters causes the collapse of population growth. In this work, using the reference strain PA14 and a clinical isolate from a burn patient, we demonstrate that the initial amount of public goods (exoprotease) that comes with the inoculum in each sequential culture is essential for maintaining population growth and that eliminating the exoprotease in the inoculum leads to rapid population collapse. Therefore, our results suggest that sequential washes should be combined with public good inhibitors to more effectively combat P. aeruginosa infections