Contributions of point extragalactic sources to the Cosmic Microwave Background bispectrum

All the analyses of Cosmic Microwave Background (CMB) temperature maps up--to--date show that CMB anisotropies follow a Gaussian distribution. On the other hand, astrophysical foregrounds which hamper the detection of the CMB angular power spectrum, are not Gaussian distributed on the sky. Therefore, they should give a sizeable contribution to the CMB bispectrum. In fact, the first year data of the Wilkinson Microwave Anisotropy Probe (WMAP) mission have allowed the {\it first} detection of the extragalactic source contribution to the CMB bispectrum at 41 GHz and, at the same time, much tighter limits than before to non--Gaussian primordial fluctuations. In view of the above and for achieving higher precision in current and future CMB measurements of non--Gaussianity, in this paper we discuss a comprehensive assessment of the bispectrum due to either uncorrelated and clustered extragalactic point sources in the whole frequency interval around the CMB intensity peak. Our calculations, based on current cosmological evolution models for sources, show that the reduced angular bispectrum due to point sources, $b_{ps}$, should be detectable in all WMAP and Planck frequency channels. We also find agreement with the results on $b_{ps}$ at 41 GHz coming from the analysis of the first year WMAP data. Moreover, by comparing $b_{ps}$ with the primordial reduced CMB bispectrum, we find that only the peak value of the primordial bispectrum (which appears at $l\simeq 200$) results greater than $b_{ps}$ in a frequency window around the intensity peak of the CMB. The amplitude of this window basically depends on the capability of the source detection algorithms (i.e., on the achievable flux detection limit, $S_{lim}$, for sources).Comment: 26 pages, 6 Figures, use AasTex5.0, ApJ, in press, Oct. 10, 2003 Issu

Those wonderful elastic waves

We consider in a simple and general way elastic waves in isotropic and anisotropic media, their polarization, speeds, reflection from interfaces with mode conversion, and surface waves. Reflection of quasi transverse waves in anisotropic media from a free surface is shown to be characterized by three critical angles.Comment: 11 Figures 26 page

Addition of a dairy fraction rich in milk fat globule membrane to a high-saturated fat meal reduces the postprandial insulinaemic and inflammatory response in overweight and obese adults.

Meals high in SFA, particularly palmitate, are associated with postprandial inflammation and insulin resistance. Milk fat globule membrane (MFGM) has anti-inflammatory properties that may attenuate the negative effects of SFA-rich meals. Our objective was to examine the postprandial metabolic and inflammatory response to a high-fat meal composed of palm oil (PO) compared with PO with an added dairy fraction rich in MFGM (PO+MFGM) in overweight and obese men and women (n 36) in a randomised, double-blinded, cross-over trial. Participants consumed two isoenergetic high-fat meals composed of a smoothie enriched with PO with v. without a cream-derived complex milk lipid fraction ( dairy fraction rich in MFGM) separated by a washout of 1-2 weeks. Serum cytokines, adhesion molecules, cortisol and markers of inflammation were measured at fasting, and at 1, 3 and 6 h postprandially. Glucose, insulin and lipid profiles were analysed in plasma. Consumption of the PO + MFGM v. PO meal resulted in lower total cholesterol (P = 0·021), LDL-cholesterol (P = 0·046), soluble intracellular adhesion molecule (P = 0·005) and insulin (P = 0·005) incremental AUC, and increased IL-10 (P = 0·013). Individuals with high baseline C-reactive protein (CRP) concentrations (≥3 mg/l, n 17) had higher (P = 0·030) insulin at 1 h after the PO meal than individuals with CRP concentrations <3 mg/l (n 19). The addition of MFGM attenuated this difference between CRP groups. The addition of a dairy fraction rich in MFGM attenuated the negative effects of a high-SFA meal by reducing postprandial cholesterol, inflammatory markers and insulin response in overweight and obese individuals, particularly in those with elevated CRP

Consumption of a high-fat meal containing cheese compared with a vegan alternative lowers postprandial C-reactive protein in overweight and obese individuals with metabolic abnormalities: a randomised controlled cross-over study.

Dietary recommendations suggest decreased consumption of SFA to minimise CVD risk; however, not all foods rich in SFA are equivalent. To evaluate the effects of SFA in a dairy food matrix, as Cheddar cheese, v. SFA from a vegan-alternative test meal on postprandial inflammatory markers, a randomised controlled cross-over trial was conducted in twenty overweight or obese adults with metabolic abnormalities. Individuals consumed two isoenergetic high-fat mixed meals separated by a 1- to 2-week washout period. Serum was collected at baseline, and at 1, 3 and 6 h postprandially and analysed for inflammatory markers (IL-6, IL-8, IL-10, IL-17, IL-18, TNFα, monocyte chemotactic protein-1 (MCP-1)), acute-phase proteins C-reactive protein (CRP) and serum amyloid-A (SAA), cellular adhesion molecules and blood lipids, glucose and insulin. Following both high-fat test meals, postprandial TAG concentrations rose steadily (P < 0·05) without a decrease by 6 h. The incremental AUC (iAUC) for CRP was significantly lower (P < 0·05) in response to the cheese compared with the vegan-alternative test meal. A treatment effect was not observed for any other inflammatory markers; however, for both test meals, multiple markers significantly changed from baseline over the 6 h postprandial period (IL-6, IL-8, IL-18, TNFα, MCP-1, SAA). Saturated fat in the form of a cheese matrix reduced the iAUC for CRP compared with a vegan-alternative test meal during the postprandial 6 h period. The study is registered at clinicaltrials.gov under NCT01803633

Condensation Transitions in a One-Dimensional Zero-Range Process with a Single Defect Site

Condensation occurs in nonequilibrium steady states when a finite fraction of particles in the system occupies a single lattice site. We study condensation transitions in a one-dimensional zero-range process with a single defect site. The system is analysed in the grand canonical and canonical ensembles and the two are contrasted. Two distinct condensation mechanisms are found in the grand canonical ensemble. Discrepancies between the infinite and large but finite systems' particle current versus particle density diagrams are investigated and an explanation for how the finite current goes above a maximum value predicted for infinite systems is found in the canonical ensemble.Comment: 18 pages, 4 figures, revtex

The ets-Related Transcription Factor GABP Directs Bidirectional Transcription

Approximately 10% of genes in the human genome are distributed such that their transcription start sites are located less than 1 kb apart on opposite strands. These divergent gene pairs have a single intergenic segment of DNA, which in some cases appears to share regulatory elements, but it is unclear whether these regions represent functional bidirectional promoters or two overlapping promoters. A recent study showed that divergent promoters are enriched for consensus binding sequences of a small group of transcription factors, including the ubiquitous ets-family transcription factor GA-binding protein (GABP). Here we show that GABP binds to more than 80% of divergent promoters in at least one cell type. Furthermore, we demonstrate that GABP binding is correlated and associated with bidirectional transcriptional activity in a luciferase transfection assay. In addition, we find that the addition of a strict consensus GABP site into a set of promoters that normally function in only one direction significantly increases activity in the opposite direction in 67% of cases. Our findings demonstrate that GABP regulates the majority of divergent promoters and suggest that bidirectional transcriptional activity is mediated through GABP binding and transactivation at both divergent and nondivergent promoters

An Infrared Determination of the Reddening and Distance to Dwingeloo 1

We present for the first time infrared observations of the nearby highly obscured galaxy Dwingeloo 1 (Dw1), including deep H-band imaging covering a total of 4.9x4.9 arcmin, together with J and Ks imaging of the central 2.5x2.5 arcmin. We used the small dispersion of the intrinsic infrared colors of spiral galaxies to determine an infrared H-band extinction of A_H = 0.47+/-0.11 mag towards Dw1. In using infrared colors, the uncertainties in the reddening and distance are reduced by a factor of three. The H-band magnitude corrected for extinction and the infrared Tully-Fisher relation are then used to estimate a distance modulus of (m-M)_0 = 28.62+/-0.27, and thus a distance of d = 5.3 {+0.7/-0.6} Mpc, which puts Dw1 at the far end of the IC342/Maffei 1 & 2 group. Our result is largely independent of the nature of the reddening law because we estimated both the reddening and the distance at the same wavelength range.Comment: 20 pages, 2 figures, see http://nicmos2.as.arizona.edu/~aalonso/Dw1/dw1_paper.htm

Dengue epidemic in southern Vietnam, 1998.

A widespread epidemic of dengue hemorrhagic fever (DHF) occurred in southern Vietnam in 1998, with 438.98 cases/100,000 population and 342 deaths. The number of DHF cases and deaths per 100,000 population increased 152.4% and 151.8%, respectively, over a 1997 epidemic. Dengue viruses were isolated from 143 patient blood samples; DEN-3 virus was identified as the predominant serotype, although a resurgence of DEN-4 was noted

Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.

There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full thickness human donor esophagi to create and validate the ex vivo function of mucosa and smooth muscle (n = 25). Explanted tissue was tested for contractile responses to carbachol and histamine. We then treated ex vivo human esophageal mucosa with a cytokine cocktail to closely mimic the Th2 and inflammatory milieu of eosinophilic esophagitis (EoE) and assessed alterations in smooth muscle and extracellular matrix function and stiffening. We found that full thickness human esophagus as well as the individual layers of circular and longitudinal muscularis propria developed tension in response to carbachol ex vivo and that mucosa demonstrated squamous cell differentiation. Treatment of mucosa with Th2 and fibrotic cytokines recapitulated the majority of the clinical Eosinophilic Esophagitis Diagnostic Profile (EDP) on fluidic transcriptional microarray. Transforming growth factor-beta-1 (TGFβ1) increased gene expression of fibronectin, smooth muscle actin, and phospholamban (p < 0.001). The EoE cocktail also increased stiffness and decreased mucosal compliance, akin to the functional alterations in EoE (p = 0.001). This work establishes a new, transcriptionally intact and physiologically functional human platform to model esophageal tissue responses in EoE

Dietary fat and not calcium supplementation or dairy product consumption is associated with changes in anthropometrics during a randomized, placebo-controlled energy-restriction trial

Insufficient calcium intake has been proposed to cause unbalanced energy partitioning leading to obesity. However, weight loss interventions including dietary calcium or dairy product consumption have not reported changes in lipid metabolism measured by the plasma lipidome