Disease Predilection and Molecular Heterogeneity of the Murine Aorta are Intrinsic to the Vessel Wall

Vascular diseases such as atherosclerosis or aneurysmal disease preferentially affect different parts of the arterial system. Despite this heterogeneous pattern of disease within the arterial system, the contribution of different smooth muscle cell phenotypes to this pattern has not been well studied. We investigated aortic disease susceptibility and epigenetic differences within different regions of the murine aorta. Quantitative analyses showed more numerous atherosclerotic plaques and larger aneurysms in the ascending aorta compared to the descending thoracic aorta in apoE-/- and fbn1C1039G/+ mice, respectively. Interferon-γ and transforming growth factor-β responses, characteristic of these disease processes, were greater in the ascending vs. descending thoracic aorta. There was differential gene expression within the aorta and a Hox code was found for the murine arterial vasculature along the anteriorâposterior axis. Transplantation ofascending and descending thoracic aortic segments to the abdominal aorta of syngeneic recipients confirmed that the propensity for atherosclerotic disease and the expression of selective molecular markers were innate properties of the vessel wall and not dependent on regional hemodynamic factors or paracrine signals from surrounding tissues. The epigenetic changes were also stable in cultured cells despite identical in vitro conditions. Our work supports the concept of intrinsic differences between vascular smooth muscle cells from various arteries that may play a role in disease pathogenesis

Stem Cell Therapy for Retinopathy of Prematurity

Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness that severely affecting the quality of life of these children. Few treatment options are available but without favorable outcomes. Stem cell therapy, through its proven potential in tissue regeneration, provides an attractive therapeutic approach in treating ROP and thereby restoring vision.published_or_final_versio

Multicolored parallelisms of Hamiltonian cycles

AbstractA subgraph in an edge-colored graph is multicolored if all its edges receive distinct colors. In this paper, we prove that a complete graph on 2m+1 vertices K2m+1 can be properly edge-colored with 2m+1 colors in such a way that the edges of K2m+1 can be partitioned into m multicolored Hamiltonian cycles

Similarity transformations approach for a generalized Fokker-Planck equation

By using similarity transformations approach, the exact propagator for a generalized one-dimensional Fokker-Planck equation, with linear drift force and space-time dependent diffusion coefficient, is obtained. The method is simple and enables us to recover and generalize special cases studied through the Lie algebraic approach and the Green function technique.Comment: 8 pages, no figure