Multiple Keratoacanthomas, Philadelphia Chromosome+ Acute Lymphoblastic Leukemia, and Dasatinib: A Case Report

Background: Treatment for adult Philadelphia chromosome+ acute lymphoblastic leukemia includes using dasatinib, a tyrosine kinase inhibitor. Cutaneous squamous cell carcinomas and keratoacanthomas are common findings in patients treated with BRAF inhibitors of tyrosine kinases. No documentation of dasatinib inducing multiple keratoacanthomas, squamous cell carcinomas type during treatment of Philadelphia chromosome+ acute lymphoblastic leukemia is currently available. Case: A 77-year-old Caucasian male presented to the dermatology clinic two months after starting treatment with dasatinib for Philadelphia chromosome positive+ acute lymphoblastic leukemia. Biopsies confirmed the lesions on the arms, chest, legs and back as keratoacanthoma (KA) type of squamous cell carcinomas (SCCs). The cutaneous lesions were surgically removed and no new or recurrent lesions were detected since their initial rapid onset despite continued dasatinib therapy. Conclusion: This report of the rapid onset of keratoacanthoma type squamous cell carcinomas in a patient with Philadelphia chromosome+ acute lymphoblastic leukemia treated with dasatinib is presumed to be the first due to the rarity of adult Philadelphia chromosome+ acute lymphoblastic leukemia. This report documents another tyrosine kinase inhibitor that is associated with the eruption of keratoacanthomas, and adds to the literature regarding the regularity of this relatively common side effect, which may have treatment other than surgery if only a few lesions are present

Ship traffic connects Antarctica's fragile coasts to worldwide ecosystems.

Antarctica, an isolated and long considered pristine wilderness, is becoming increasingly exposed to the negative effects of ship-borne human activity, and especially the introduction of invasive species. Here, we provide a comprehensive quantitative analysis of ship movements into Antarctic waters and a spatially explicit assessment of introduction risk for nonnative marine species in all Antarctic waters. We show that vessels traverse Antarctica's isolating natural barriers, connecting it directly via an extensive network of ship activity to all global regions, especially South Atlantic and European ports. Ship visits are more than seven times higher to the Antarctic Peninsula (especially east of Anvers Island) and the South Shetland Islands than elsewhere around Antarctica, together accounting for 88% of visits to Southern Ocean ecoregions. Contrary to expectations, we show that while the five recognized "Antarctic Gateway cities" are important last ports of call, especially for research and tourism vessels, an additional 53 ports had vessels directly departing to Antarctica from 2014 to 2018. We identify ports outside Antarctica where biosecurity interventions could be most effectively implemented and the most vulnerable Antarctic locations where monitoring programs for high-risk invaders should be established

Considerations in No-Till Small Grain Production

Small grains have become an important component of many crop rotations in Kentucky. Seedbed preparation has typically involved various degrees of tillage in which much of the residue from the previous crop is buried. Under such conditions, a field may be vulnerable to severe soil loss during periods of heavy rainfall until the plants have produced enough vegetative growth to cover the soil surface. Eliminating tillage in small grain production would not only reduce soil loss but also reduce labor cost and increase the timeliness of planting. Interest in no-till small grain production is growing. One survey reports that in 1983 approximately 50,000 acres of small grains were planted using no-tillage in Kentucky. Research information on winter survival, seed placement, residue management, and nitrogen fertilization is now becoming available

Engineering robust polar chiral clathrate crystals

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Royal Society of Chemistry 2013.The R-(+)-enantiomeric form of Dianin's compound and the S-(+)-enantiomeric form of its direct thiachroman analogue both obtained chromatographically employing a cellulose tris(3,5-dimethylphenylcarbamate) column, are shown to undergo supramolecular assembly to form a polar clathrate lattice which is stable even in the absence of a consolidating guest component

Physical limits of inference

I show that physical devices that perform observation, prediction, or recollection share an underlying mathematical structure. I call devices with that structure "inference devices". I present a set of existence and impossibility results concerning inference devices. These results hold independent of the precise physical laws governing our universe. In a limited sense, the impossibility results establish that Laplace was wrong to claim that even in a classical, non-chaotic universe the future can be unerringly predicted, given sufficient knowledge of the present. Alternatively, these impossibility results can be viewed as a non-quantum mechanical "uncertainty principle". Next I explore the close connections between the mathematics of inference devices and of Turing Machines. In particular, the impossibility results for inference devices are similar to the Halting theorem for TM's. Furthermore, one can define an analog of Universal TM's (UTM's) for inference devices. I call those analogs "strong inference devices". I use strong inference devices to define the "inference complexity" of an inference task, which is the analog of the Kolmogorov complexity of computing a string. However no universe can contain more than one strong inference device. So whereas the Kolmogorov complexity of a string is arbitrary up to specification of the UTM, there is no such arbitrariness in the inference complexity of an inference task. I end by discussing the philosophical implications of these results, e.g., for whether the universe "is" a computer.Comment: 43 pages, updated version of Physica D version, which originally appeared in 2007 CNLS conference on unconventional computatio

Differences in Orgasm Frequency Between Gay, Lesbian, Bisexual, and Heterosexual Men and Women in a U.S. National Sample

There is a notable gap between heterosexual men and women in frequency of orgasm during sex. Little is known, however, about sexual orientation differences in orgasm frequency. We examined how over 30 different traits or behaviors were associated with frequency of orgasm when sexually intimate during the past month. We analyzed a large US sample of adults (N = 52,588) who identified as heterosexual men (n = 26,032), gay men (n = 452), bisexual men (n = 550), lesbian women (n = 340), bisexual women (n = 1112), and heterosexual women (n = 24,102). Heterosexual men were most likely to say they usually-always orgasmed when sexually intimate (95%), followed by gay men (89%), bisexual men (88%), lesbian women (86%), bisexual women (66%), and heterosexual women (65%). Compared to women who orgasmed less frequently, women who orgasmed more frequently were more likely to: receive more oral sex, have longer duration of last sex, be more satisfied with their relationship, ask for what they want in bed, praise their partner for something they did in bed, call/email to tease about doing something sexual, wear sexy lingerie, try new sexual positions, anal stimulation, act out fantasies, incorporate sexy talk, and express love during sex. Women were more likely to orgasm if their last sexual encounter included deep kissing, manual genital stimulation, and/or oral sex in addition to vaginal intercourse. We consider sociocultural and evolutionary explanations for these orgasm gaps. The results suggest a variety of behaviors couples can try to increase orgasm frequency

2002-2003 Kentucky Canola Variety Performance Test

Winter canola is a crop that is well suited for Kentucky’s climate and crop rotation, but production peaked at 20,000 acres in 1989and has since declined mainly due to winter hardiness concerns. Changes in the 2002 farm bill have once again caused farmers to consider converting some of their wheat acreage to canola production. For the past several years, plant breeders have been working to improve canola’s winter hardiness and have released several varieties that seem to be better suited for Kentucky’s variable winters than the varieties grown in the late 1980s. A study was initiated in the fall of 2002 to evaluate emergence, winter hardiness, and yield of 10 canola varieties thought to have characteristics well suited for production in Kentucky. Results presented in this paper are for the first year of the study and do not reflect variety performance over a wide range of climatic conditions. Results from the University of Missouri’s canola variety trials are available at http://www.psu.missouri.edu/ cropsys/Alternative_Crops/ and should also be consulted before deciding on a variety