Intracavity weak nonlinear phase shifts with single photon driving

We investigate a doubly resonant optical cavity containing a Kerr nonlinear medium that couples two modes by a cross phase modulation. One of these modes is driven by a single photon pulsed field, and the other mode is driven by a coherent state. We find an intrinsic phase noise mechanism for the cross phase shift on the coherent beam which can be attributed to the random emission times of single photons from the cavity. An application to a weak nonlinearity phase gate is discussed

Towards a novel carbon device for the treatment of sepsis

Sepsis is a systemic inflammatory response to infection in which the balance of pro- andanti-inflammatory mediators, which normally isolate and eliminate infection, is disrupted[1]. Gram negative sepsis is initiated by bacterial endotoxin release which activatesmacrophages and circulating monocytes to release TNF and IL-1β followed by IL-6 andother inflammatory cytokines [2]. As the disease progresses, an unregulatedinflammatory response results in, tissue injury, haematological dysfunction and organdysfunction. Severe sepsis, involving organ hypoperfusion may be further complicatedby hypotension that is unresponsive to adequate fluid replacement, resulting in septicshock and finally death [3].Despite improvements in anti-microbial and supportive therapies, sepsis remains asignificant cause of morbidity and mortality in ICUs worldwide [4]. The complexity ofprocesses mediating the progression of sepsis suggests that an extracorporeal devicecombining blood filtration with adsorption of a wide range of toxins, and inflammatorymediators offers the most comprehensive treatment strategy. However, no such deviceexists at present. A novel, uncoated, polymer pyrolysed synthetic carbon device isproposed which combines the superior adsorption properties of uncoated activatedcarbons with the capacity to manipulate porous structure for controlled adsorption oftarget plasma proteins and polypeptides [5]. Preliminary haemocompatibility andadsorptive capacity was assessed using a carbon matrix prototype

Universal quantum control in irreducible state-space sectors: application to bosonic and spin-boson systems

We analyze the dynamical-algebraic approach to universal quantum control introduced in P. Zanardi, S. Lloyd, quant-ph/0305013. The quantum state-space $\cal H$ encoding information decomposes into irreducible sectors and subsystems associated to the group of available evolutions. If this group coincides with the unitary part of the group-algebra \CC{\cal K} of some group $\cal K$ then universal control is achievable over the ${\cal K}$-irreducible components of $\cal H$. This general strategy is applied to different kind of bosonic systems. We first consider massive bosons in a double-well and show how to achieve universal control over all finite-dimensional Fock sectors. We then discuss a multi-mode massless case giving the conditions for generating the whole infinite-dimensional multi-mode Heisenberg-Weyl enveloping-algebra. Finally we show how to use an auxiliary bosonic mode coupled to finite-dimensional systems to generate high-order non-linearities needed for universal control.Comment: 10 pages, LaTeX, no figure

Sequential bottlenecks drive viral evolution in early acute Hepatitis C virus infection

Hepatitis C is a pandemic human RNA virus, which commonly causes chronic infection and liver disease. The characterization of viral populations that successfully initiate infection, and also those that drive progression to chronicity is instrumental for understanding pathogenesis and vaccine design. A comprehensive and longitudinal analysis of the viral population was conducted in four subjects followed from very early acute infection to resolution of disease outcome. By means of next generation sequencing (NGS) and standard cloning/Sanger sequencing, genetic diversity and viral variants were quantified over the course of the infection at frequencies as low as 0.1%. Phylogenetic analysis of reassembled viral variants revealed acute infection was dominated by two sequential bottleneck events, irrespective of subsequent chronicity or clearance. The first bottleneck was associated with transmission, with one to two viral variants successfully establishing infection. The second occurred approximately 100 days post-infection, and was characterized by a decline in viral diversity. In the two subjects who developed chronic infection, this second bottleneck was followed by the emergence of a new viral population, which evolved from the founder variants via a selective sweep with fixation in a small number of mutated sites. The diversity at sites with non-synonymous mutation was higher in predicted cytotoxic T cell epitopes, suggesting immune-driven evolution. These results provide the first detailed analysis of early within-host evolution of HCV, indicating strong selective forces limit viral evolution in the acute phase of infection

G\"odel Incompleteness and the Black Hole Information Paradox

Semiclassical reasoning suggests that the process by which an object collapses into a black hole and then evaporates by emitting Hawking radiation may destroy information, a problem often referred to as the black hole information paradox. Further, there seems to be no unique prediction of where the information about the collapsing body is localized. We propose that the latter aspect of the paradox may be a manifestation of an inconsistent self-reference in the semiclassical theory of black hole evolution. This suggests the inadequacy of the semiclassical approach or, at worst, that standard quantum mechanics and general relavity are fundamentally incompatible. One option for the resolution for the paradox in the localization is to identify the G\"odel-like incompleteness that corresponds to an imposition of consistency, and introduce possibly new physics that supplies this incompleteness. Another option is to modify the theory in such a way as to prohibit self-reference. We discuss various possible scenarios to implement these options, including eternally collapsing objects, black hole remnants, black hole final states, and simple variants of semiclassical quantum gravity.Comment: 14 pages, 2 figures; revised according to journal requirement

A Behavioural Foundation for Natural Computing and a Programmability Test

What does it mean to claim that a physical or natural system computes? One answer, endorsed here, is that computing is about programming a system to behave in different ways. This paper offers an account of what it means for a physical system to compute based on this notion. It proposes a behavioural characterisation of computing in terms of a measure of programmability, which reflects a system's ability to react to external stimuli. The proposed measure of programmability is useful for classifying computers in terms of the apparent algorithmic complexity of their evolution in time. I make some specific proposals in this connection and discuss this approach in the context of other behavioural approaches, notably Turing's test of machine intelligence. I also anticipate possible objections and consider the applicability of these proposals to the task of relating abstract computation to nature-like computation.Comment: 37 pages, 4 figures. Based on an invited Talk at the Symposium on Natural/Unconventional Computing and its Philosophical Significance, Alan Turing World Congress 2012, Birmingham, UK. http://link.springer.com/article/10.1007/s13347-012-0095-2 Ref. glitch fixed in 2nd. version; Philosophy & Technology (special issue on History and Philosophy of Computing), Springer, 201

Computational and Biological Analogies for Understanding Fine-Tuned Parameters in Physics

In this philosophical paper, we explore computational and biological analogies to address the fine-tuning problem in cosmology. We first clarify what it means for physical constants or initial conditions to be fine-tuned. We review important distinctions such as the dimensionless and dimensional physical constants, and the classification of constants proposed by Levy-Leblond. Then we explore how two great analogies, computational and biological, can give new insights into our problem. This paper includes a preliminary study to examine the two analogies. Importantly, analogies are both useful and fundamental cognitive tools, but can also be misused or misinterpreted. The idea that our universe might be modelled as a computational entity is analysed, and we discuss the distinction between physical laws and initial conditions using algorithmic information theory. Smolin introduced the theory of "Cosmological Natural Selection" with a biological analogy in mind. We examine an extension of this analogy involving intelligent life. We discuss if and how this extension could be legitimated. Keywords: origin of the universe, fine-tuning, physical constants, initial conditions, computational universe, biological universe, role of intelligent life, cosmological natural selection, cosmological artificial selection, artificial cosmogenesis.Comment: 25 pages, Foundations of Science, in pres

Environment-Induced Decoherence and the Transition From Quantum to Classical

We study dynamics of quantum open systems, paying special attention to those aspects of their evolution which are relevant to the transition from quantum to classical. We begin with a discussion of the conditional dynamics of simple systems. The resulting models are straightforward but suffice to illustrate basic physical ideas behind quantum measurements and decoherence. To discuss decoherence and environment-induced superselection einselection in a more general setting, we sketch perturbative as well as exact derivations of several master equations valid for various systems. Using these equations we study einselection employing the general strategy of the predictability sieve. Assumptions that are usually made in the discussion of decoherence are critically reexamined along with the ``standard lore'' to which they lead. Restoration of quantum-classical correspondence in systems that are classically chaotic is discussed. The dynamical second law -it is shown- can be traced to the same phenomena that allow for the restoration of the correspondence principle in decohering chaotic systems (where it is otherwise lost on a very short time-scale). Quantum error correction is discussed as an example of an anti-decoherence strategy. Implications of decoherence and einselection for the interpretation of quantum theory are briefly pointed out.Comment: 80 pages, 7 figures included, Lectures given by both authors at the 72nd Les Houches Summer School on "Coherent Matter Waves", July-August 199

The Mathematical Universe

I explore physics implications of the External Reality Hypothesis (ERH) that there exists an external physical reality completely independent of us humans. I argue that with a sufficiently broad definition of mathematics, it implies the Mathematical Universe Hypothesis (MUH) that our physical world is an abstract mathematical structure. I discuss various implications of the ERH and MUH, ranging from standard physics topics like symmetries, irreducible representations, units, free parameters, randomness and initial conditions to broader issues like consciousness, parallel universes and Godel incompleteness. I hypothesize that only computable and decidable (in Godel's sense) structures exist, which alleviates the cosmological measure problem and help explain why our physical laws appear so simple. I also comment on the intimate relation between mathematical structures, computations, simulations and physical systems.Comment: Replaced to match accepted Found. Phys. version, 31 pages, 5 figs; more details at http://space.mit.edu/home/tegmark/toe.htm