2 research outputs found
A Method for Synthesis of Homoallylic Bromide
Cyclopropyl
Grignard reagents react with carbonyl compounds in
the presence of diethyl phosphite to give homoallylic bromides. The
reaction is effectively carried out under mild conditions in a one-pot
fashion with moderate to good yields
Zwitterionic Sulfhydryl Sulfobetaine Stabilized Platinum Nanoparticles for Enhanced Dopamine Detection and Antitumor Ability
Herein, three kinds of molecules
were used to modify
the surface
of platinum nanoparticles (Pt NPs) to tune their surface charge. Zwitterionic
thiol-functionalized sulfobetaine (SH-SB) stabilized Pt NPs (SH-SB/Pt
NPs) had the highest oxidase activity and peroxidase activity in the
prepared platinum nanozymes due to the generation of reactive oxygen
species. In addition, a colorimetric dopamine detection method was
established based on the peroxidase activity of SH-SB/Pt NPs. This
method had a wide range (0–120 μM), a low detection limit
(0.244 μM), and high specificity. More importantly, SH-SB/Pt
NPs displayed little hemolysis and good stability in the presence
of proteins. SH-SB/Pt NPs demonstrated high cytotoxicity in
vitro and good antitumor ability in vivo, which was attributed to the photothermal conversion ability of
SH-SB/Pt NPs and the generation of reactive oxygen species in the
acidic environment. The surface modification of nanozymes using zwitterionic
molecules opens a new method to improve the catalytic activity and
antitumor ability of nanozymes