Research on the End Surface Dent of the Main Shaft Forging

In the process of the stretching of the shaft forgings, if the process parameters are not properly selected, the end-face dent will take place. The end-face dent affects the performance of large forgings and leads to much material wasting. Finite element method was employed to perform numerical simulation of the stretching of a main shaft with an upper flat anvil and a lower V-shaped anvil. The orthogonal test table was designed by selecting the anvil width, the Reduction ratio and the feed as influencing factors. Accordingly, simulations were carried out to solve the end-face dent values under different parameter combinations. The analysis showed that the optimal parameter combination gave an anvil width ratio of 0.75, a Reduction ratio of 0.2, and an initial feed of 300 mm. Through extremum difference analysis, it was found that among the three factors are the feed, the reduction ratio, and the anvil width ratio in the decreasing order of the influence on the end- face dent. Comprehensive analysis showed that when the anvil is relatively narrow, increasing the relative feed can reduce the end-surface dent remarkably. It is advisable that during the stretching of shaft forgings with a flat upper anvil and a V-shaped lower anvil, the combination of the anvil width ratio of 0.75, the reduction ratio of 0.2, and increasing the feed can reduce the end-face dent, thereby reducing the end cutting and saving material costs

An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy

BACKGROUND: Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significance of Fra-1 expression in breast carcinogenesis. METHODS: The expression of Fra-1 was investigated by immunohistochemistry in neoplastic breast diseases ranging from benign fibroadenoma to very aggressive undifferentiated carcinoma. The correlations of Fra-1 expression with other indicators of breast carcinoma prognosis (ER, PR and ErbB2 receptors) were analyzed. RESULTS: All neoplastic breast tissues, either benign or malignant breast tissues, were nuclear immunoreactive for Fra-1-recognizing antibody. The pattern of Fra-1 expression by benign neoplastic cells was predominantly nuclear. However, the nuclear/cytoplasmic concomitant immunoreactivity was observed in all types of breast carcinomas. A clear shift in Fra-1 immunoreactivity, from an exclusively nuclear to a simultaneous nuclear and cytoplasmic localization was noticed in ~90% of breast carcinomas. CONCLUSION: The overall expression, pattern and intensity of Fra-1 proteins were correlated with breast oncogenesis. Overexpression of Fra-1, leading to a persistent high cytoplasmic accumulation, may play a role in the process of breast carcinogenesis

Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model

<p>Abstract</p> <p>Background</p> <p>c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer. Recently, it has been reported that overexpression of c-Jun in breast cancer cell line MCF-7 resulted in increased AP-1 activity, motility and invasiveness of the cells <it>in vitro </it>and tumor formation in nude mice. However, the role of c-Jun in metastasis of human breast cancer <it>in vivo </it>is currently unknown.</p> <p>Methods</p> <p>To further investigate the direct involvement of c-Jun in tumorigenesis and metastasis, in the present study, the effects of c-Jun overexpression were studied in both <it>in vitro </it>and in nude mice.</p> <p>Results</p> <p>Ectopic overexpression of c-Jun promoted the growth of MCF-7 cells and resulted in a significant increase in the percentage of cells in S phase and increased motility and invasiveness. Introduction of c-Jun gene alone into weakly invasive MCF-7 cells resulted in the transfected cells capable of metastasizing to the nude mouse liver following tail vein injection.</p> <p>Conclusion</p> <p>The present study confirms that overexpression of c-Jun contributes to a more invasive phenotype in MCF-7 cells. It indicates an interesting relationship between c-Jun expression and increased property of adhesion, migration and <it>in vivo </it>liver metastasis of MCF-7/c-Jun cells. The results provide further evidence that c-Jun is involved in the metastasis of breast cancer. The finding also opens an opportunity for development of anti-c-Jun strategies in breast cancer therapy.</p

The Design of Focal Plane Splitting Unit in a Hyperspectral Lidar System

A hyperspectral lidar system with focal plane splitting unit is proposed, including an off-axis receiving telescope, a grating spectrometer, and a single-tube detector array. The spectrum of the system covers 380-930nm, and is separated by grating spectrometer. The microlens-fiber coupling system guides the echo signal of 50 channels into each detector. The system solves the data processing problem of the bandwidth and gain the line array and area array detector in traditional hyperspectral lidar. And it also meets the requirement of the high efficiency splitting coupling and weak signal acquisition and detection

The Design of Focal Plane Splitting Unit in a Hyperspectral Lidar System

A hyperspectral lidar system with focal plane splitting unit is proposed, including an off-axis receiving telescope, a grating spectrometer, and a single-tube detector array. The spectrum of the system covers 380-930nm, and is separated by grating spectrometer. The microlens-fiber coupling system guides the echo signal of 50 channels into each detector. The system solves the data processing problem of the bandwidth and gain the line array and area array detector in traditional hyperspectral lidar. And it also meets the requirement of the high efficiency splitting coupling and weak signal acquisition and detection

Thermal Performance of the Thin Heat Pipe for Cooling of Solid-State Drives

With the rapid development of information science and technology, the demand for computer data processing is increasing, resulting in the rapid growth of the demand for high-power and high-performance solid-state drives (SSDs). The stable operation of SSDs plays an important role in ensuring the reliable working conditions and appropriate temperature of information technology equipment, rack servers, and related facilities. However, SSDs usually have significant heat emissions, putting forward higher requirements for temperature and humidity control, and consequently the heat sink system for cooling is essential to maintain the proper working state of SSDs. In this paper, a new type of thin heat pipe (THP) heat sink is proposed, and the heat transfer performance and cooling effect are experimentally and numerically studied. The numerical results are compared with experimental results, which showed an error within 5%. Single and double heat pipes were investigated under different input powers (from 5 W to 50 W) and different placement angles between 0&deg; and 90&deg;. The heat transfer performance of the new heat sink is analyzed by the startup performance, the evaporator temperature, and the total thermal resistance. The results show that the new double THPs with a 90&deg; angle have a great advantage in the heat transfer performance of SSDs. The research is of great significance for the design and optimization of the SSDs&rsquo; cooling system in practical applications

Parameter Simulation and Design of an Airborne Hyperspectral Imaging LiDAR System

With continuous technological development, the future development trend of LiDAR in the field of remote sensing and mapping is to obtain the elevation and spectral information of ground targets simultaneously. Airborne hyperspectral imaging LiDAR inherits the advantages of active and passive remote sensing detection. This paper presents a simulation method to determine the design parameters of an airborne hyperspectral imaging LiDAR system. In accordance with the hyperspectral imaging LiDAR equation and optical design principles, the atmospheric transmission model and the reflectance spectrum of specific ground targets are utilized. The design parameters and laser emission spectrum of the hyperspectral LiDAR system are considered, and the signal-to-noise ratio of the system is obtained through simulation. Without considering the effect of detector gain and electronic amplification on the signal-to-noise ratio, three optical fibers are coupled into a detection channel, and the power spectral density emitted by the supercontinuum laser is simulated by assuming that the signal-to-noise ratio is equal to 1. The power spectral density emitted by the laser must not be less than 15 mW/nm in the shortwave direction. During the simulation process, the design parameters of the hyperspectral LiDAR system are preliminarily demonstrated, and the feasibility of the hyperspectral imaging LiDAR system design is theoretically guaranteed in combination with the design requirements of the supercontinuum laser. The spectral resolution of a single optical fiber of the hyperspectral LiDAR system is set to 2.5 nm. In the actual prototype system, multiple optical fibers can be coupled into a detection channel in accordance with application needs to further improve the signal-to-noise ratio of hyperspectral LiDAR system detection