The descriptive statistics of weekly numbers of HFMD cases in Dalian from 2009 to 2014.

<p>The descriptive statistics of weekly numbers of HFMD cases in Dalian from 2009 to 2014.</p

The time analysis result of HFMD in Dalian 2009–2014.

<p>The time analysis result of HFMD in Dalian 2009–2014.</p

The early warning result for HFMD in Dalian during 2013–2014 using the number of predicted baseline data obtained from the negative binomial regression.

<p>The early warning result for HFMD in Dalian during 2013–2014 using the number of predicted baseline data obtained from the negative binomial regression.</p

The different threshold value and sensitivity for early warning at the starting of HFMD in Dalian.

<p>The different threshold value and sensitivity for early warning at the starting of HFMD in Dalian.</p

The numbers of reported HFMD cases in Dalian from 2009 to 2014.

<p>The numbers of reported HFMD cases in Dalian from 2009 to 2014.</p

Monthly cases of HFMD in Dalian 2009–2014.

<p>Monthly cases of HFMD in Dalian 2009–2014.</p

The Akaike Information Criterion (AIC) values and the parameters estimates for different rounds of iterative regression.

<p>The Akaike Information Criterion (AIC) values and the parameters estimates for different rounds of iterative regression.</p

Base-Mediated Synthesis of Unsymmetrical 1,3,5-Triazin-2-amines via Three-Component Reaction of Imidates, Guanidines, and Amides or Aldehydes

A simple and efficient method for the base-mediated synthesis of unsymmetrical 1,3,5-triazin-2-amines has been developed. The protocol uses readily available imidates, guanidines, and amides or aldehydes as the starting materials, cesium carbonate as the base, no catalyst or additive is required, and the three-component reaction provides diverse 1,3,5-triazin-2-amines in moderate to good yields with tolerance of wide functional groups