Comparison of Delay Distributions of Responses in a Home Area Network using Wi-Fi with and without in-network Data Aggregation

Smart Grid is divided into seven sub domains by NIST. The customer domain refers to the end users of electricity. In addition to the traditional role of consumer, they will also participate in generation as well as storage of energy. They would respond to signals coming from the grid and reduce or increase consumption and/or generation accordingly. For this purpose the customer premise should be equipped with an information network, which is called a Home Area Network. Architecture of a Home Area Network needs to be optimised in terms of time and energy. In this research the behaviour of a HAN in terms of time is studied. Delays of responses from the devices for the requests made by the central controller were measured for two most popular architectures, with and without in-network data aggregation. When the probability mass functions were plotted, it was evident that the delays in the two cases do not differ by much

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study.

Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans. Intestinal microbes are important contributors to variability; however, such gut microbe-drug interactions and the clinical significance of these interactions are still being elucidated. Traditional PKs can be complemented by untargeted mass spectrometry coupled with molecular networking to study the intricacies of drug metabolism. To show the utility of molecular networking on metabolism we investigated the impact of a 7-day course of cefprozil on cytochrome P450 (CYP) activity using a modified Cooperstown cocktail and assessed plasma, urine, and fecal data by targeted and untargeted metabolomics and molecular networking in healthy volunteers. This prospective study revealed that cefprozil decreased the activities of CYP1A2, CYP2C19, and CYP3A, decreased alpha diversity and increased interindividual microbiome variability. We further demonstrate a relationship between the loss of microbiome alpha diversity caused by cefprozil and increased drug and metabolite formation in fecal samples. Untargeted metabolomics/molecular networking revealed several omeprazole metabolites that we hypothesize may be metabolized by both CYP2C19 and bacteria from the gut microbiome. Our observations are consistent with the hypothesis that factors that perturb the gut microbiome, such as antibiotics, alter drug metabolism and ultimately drug efficacy and toxicity but that these effects are most strongly revealed on a per individual basis

A Tale of Two Continents: Factors Influencing Students to Major in Mathematics

Students consider the selection of their college major as one of the critical decisions in their life. Literature suggests that influencing factors can differ based on the academic discipline, student status (freshmen, declared, etc.), and geography. We select two countries, the United States and Sri Lanka, with contrasting education systems and study the factors which may have influenced students to become mathematics majors. We consider the effect of ten influencing factors, which form three clusters, namely, “Career-Related”, “Math-Related”, and “Other”. The study first reveals that the factors and clusters significantly affect student decisions in the two countries. One of the critical conclusions of the study is how the “MathRelated” cluster influences students’ decisions significantly more than the other two clusters. We also look at the difference in the impact of specific influencing factors on the two populations and find that factors related to the nature of mathematics influence US students more than Sri Lankan students. The study’s conclusions should benefit teachers and recruiters when guiding future math majors

Weak charge form factor and radius of 208Pb through parity violation in electron scattering

We use distorted wave electron scattering calculations to extract the weak charge form factor F_W(q), the weak charge radius R_W, and the point neutron radius R_n, of 208Pb from the PREX parity violating asymmetry measurement. The form factor is the Fourier transform of the weak charge density at the average momentum transfer q=0.475 fm$^{-1}$. We find F_W(q) =0.204 \pm 0.028 (exp) \pm 0.001 (model). We use the Helm model to infer the weak radius from F_W(q). We find R_W= 5.826 \pm 0.181 (exp) \pm 0.027 (model) fm. Here the exp error includes PREX statistical and systematic errors, while the model error describes the uncertainty in R_W from uncertainties in the surface thickness \sigma of the weak charge density. The weak radius is larger than the charge radius, implying a "weak charge skin" where the surface region is relatively enriched in weak charges compared to (electromagnetic) charges. We extract the point neutron radius R_n=5.751 \pm 0.175 (exp) \pm 0.026 (model) \pm 0.005 (strange) fm$, from R_W. Here there is only a very small error (strange) from possible strange quark contributions. We find R_n to be slightly smaller than R_W because of the nucleon's size. Finally, we find a neutron skin thickness of R_n-R_p=0.302\pm 0.175 (exp) \pm 0.026 (model) \pm 0.005 (strange) fm, where R_p is the point proton radius.Comment: 5 pages, 1 figure, published in Phys Rev. C. Only one change in this version: we have added one author, also to metadat

Understanding seed dormancy and germination aids conservation of rainforest species from tropical montane cloud forest: a case study confirming morphophysiological dormancy in the genus Tasmannia

Context: Seed dormancy is one issue hindering implementation of conservation actions for rainforest species. Aims: We studied dormancy and germination in Tasmannia sp. Mt Bellenden Ker and Tasmannia membranea, two tropical montane rainforest species threatened by climate change, to develop a better understanding of dormancy in the species and the genus. Methods: Dormancy was classified for T. sp. Mt Bellenden Ker on the basis of an imbibition test, analysis of embryo to seed length (E:S) ratios and germination in response to the following four dormancy-breaking treatments: (I) scarification of the seedcoat near the micropylar end; (2) removal of the seedcoat; (3) application of 100 mg L(-1)or (4) 500 mg L-1 gibberellic acid. The most effective treatment was then tested on T. membranea. The requirement for light for germination was also assessed. Key results: Both scarified and intact seeds imbibed water. Initial E:S ratios were <0.22 for both species and increased up to 0.74 after 40 days, just before radicle emergence, for T. sp. Mt Bellenden Ker. Germination proportions were significantly higher in Treatments 1 and 2 than the remaining treatments for T. sp. Mt Bellenden Ker; T. membranea responded similarly well to Treatment 1. Germination under alternating light/dark conditions was slightly, but not significantly, greater than germination in the dark alone. Conclusions: Both species have morphophysiological dormancy and treatments that remove seedcoat resistance to embryo growth facilitate germination. These treatments may improve germination in other species from the genus Tasmannia. Implications: This knowledge will aid the germination of seeds to implement conservation strategies for Tasmannia spp

Sustainability of home gardens in Masemulla forest area in Matara district

Home-gardens are meant to be sustainable land use systems that provide a variety of products andservices to the people. This study was undertaken to evaluate the sustainability of home-gardens inMasemulla forest area in Matara district. Ullala, which is a small village closed to Masernulla forestarea, was selected for the study. A survey was conducted using a random sample of 40 home-gardensin the area. Average land area ranged from 0.25 to 0.5 acres with an average family size of 2-8 andalmost all the families belonged to the low income group.Majority of home gardens (90%) consisted of three canopy layers-near the ground surface herbaceouslayer, followed by an intermediate layer of shrubs and a tree layer at the upper level. Tree densityranged from low to medium with a combination of mixed species arranged in a random way. Canopycoverage was about 15 to 50% and there were more than 50% of unutilized land areas. Speciesdiversity in the selected home-gardens was low ranging from 20-25 species and the no of woody taxa was about 5-10. Dominant tree species included jak (Artocarpus heterophvilus [; coconut (Cocosnuciferai, mango (Mangifer a indica), areca nut (Areca catechu), mahogany (Swieteniamacrophvllai etc. Majority of house holders (90%) considered cinnamon (Cinnamomum verum) asan additional income source. All the householders consumed the products of the home-gardens asfood.Less than 10% of house-holders rare animals and although there is a good potential for bee keeping,less than I% of householders practiced this. Wild-boar and wild-rat attack was one of the mainproblems in crop production. Soil erosion was also a problem in this area and less than 30% ofhouseholders practiced some form of soi I conservation methods. Half of the householders fu Ifi Iledtheir energy requirement from their home-gardens. Although there are many advantages in homegardening.householders don't pay adequate attention as they don't fully understand the various benefitsof proper home-garden ing

Prevalence of chronic kidney disease in Asia: A systematic review and analysis

Introduction The burden of chronic kidney disease (CKD) is growing rapidly around the world. However, there is limited information on the overall regional prevalence of CKD, as well as the variations in national prevalence within Asia. We aimed to consolidate available data and quantify estimates of the CKD burden in this region. Methods We systematically searched MEDLINE, Embase and Google Scholar for observational studies and contacted national experts to estimate CKD prevalence in countries of Asia (Eastern, Southern and South Eastern Asia). CKD was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 or the presence of proteinuria. For countries without reported data, we estimated CKD prevalence using agglomerative average-linkage hierarchical clustering, based on country-level risk factors and random effects meta-analysis within clusters. Published CKD prevalence data were obtained for 16 countries (of the 26 countries in the region) and estimates were made for 10 countries. Results There was substantial variation in overall and advanced (eGFR <30 mL/min/1.73 m 2) CKD prevalence (range: 7.0%-34.3% and 0.1%-17.0%, respectively). Up to an estimated 434.3 million (95% CI 350.2 to 519.7) adults have CKD in Asia, including up to 65.6 million (95% CI 42.2 to 94.9) who have advanced CKD. The greatest number of adults living with CKD were in China (up to 159.8 million, 95% CI 146.6 to 174.1) and India (up to 140.2 million, 95% CI 110.7 to 169.7), collectively having 69.1% of the total number of adults with CKD in the region. Conclusion The large number of people with CKD, and the substantial number with advanced CKD, show the need for urgent collaborative action in Asia to prevent and manage CKD and its complications

Maternal Responses in the Face of Infection Risk

When animals are sick, their physiology and behavior change in ways that can impact their offspring. Research is emerging showing that infection risk alone can also modify the physiology and behavior of healthy animals. If physiological responses to environments with high infection risk take place during reproduction, it is possible that they lead to maternal effects. Understanding whether and how high infection risk triggers maternal effects is important to elucidate how the impacts of infectious agents extend beyond infected individuals and how, in this way, they are even stronger evolutionary forces than already considered. Here, to evaluate the effects of infection risk on maternal responses, we exposed healthy female Japanese quail to either an immune-challenged (lipopolysaccharide [LPS] treated) mate or to a healthy (control) mate. We first assessed how females responded behaviorally to these treatments. Exposure to an immune-challenged or control male was immediately followed by exposure to a healthy male, to determine whether treatment affected paternity allocation. We predicted that females paired with immune-challenged males would avoid and show aggression towards those males, and that paternity would be skewed towards the healthy male. After mating, we collected eggs over a 5-day period. As an additional control, we collected eggs from immune-challenged females mated to healthy males. We tested eggs for fertilization status, embryo sex ratio, as well as albumen corticosterone, lysozyme activity, and ovotransferrin, and yolk antioxidant capacity. We predicted that immune-challenged females would show the strongest changes in the egg and embryo metrics, and that females exposed to immune-challenged males would show intermediate responses. Contrary to our predictions, we found no avoidance of immune-challenged males and no differences in terms of paternity allocation. Immune-challenged females laid fewer eggs, with an almost bimodal distribution of sex ratio for embryos. In this group, albumen ovotransferrin was the lowest, and yolk antioxidant capacity decreased over time, while it increased in the other treatments. No differences in albumen lysozyme were found. Both females that were immune-challenged and those exposed to immune-challenged males deposited progressively more corticosterone in their eggs over time, a pattern opposed to that shown by females exposed to control males. Our results suggest that egg-laying Japanese quail may be able to respond to infection risk, but that additional or prolonged sickness symptoms may be needed for more extensive maternal responses

A PRELIMINARY STUDY ON THE PRESENCE OF-HEAVY METALS IN AQUATIC PLANTS FROM A FRESHWATER WETLAND AT KELANIYA

Aquatic plants are known for uptake of heavy metals from water and sediments. Thisvery feature qualifies these plants as wastewater treatment agents. Capacity to absorb,heavy metals however, varies among plants. Three aquatic plants, Pistia stratiotes(floating), Limnocharis jlava (rooted) and Ipomoea aqualica (rooted plant with floatingrunners) from lriyawetiya wetland at Kelaniya were tested for the presence of copper,zinc, lead, nickel, cadmium, manganese, tin and chromium in the plant tissues.P. stratiotes, L. jlava and 1. aquatica plants were collected from the inlets, outlets and themiddle part of the wetland and above heavy metal concentrations in acid-digested rootand shoot samples were measured separately using atomic absorption spectrophotometer.Tin (Sn) is the heavy metal that was found in relatively large quantities in all threeplants, and Ipomoea aquatica recorded the highest content of Sn. Next highestoccurrence was observed with Cr and the contents were highest in the rooted plant, L.jlava, indicating that the sediment loads of Cr may be greater than the load in the watercolumn. All other heavy metals occur in relatively low concentrations in all three plantspecies, indicating partly the lower loading rates of these heavy metals in Iriyawetiyawetland.Occurrence of heavy metals in the roots was generally higher than that of the shoots.Greater Cr concentrations were recorded from roots of floating species, P. stratiotes andI. aquatica than the rooted species, L. flava.Except for cadmium (in P. slratioles) and manganese (in L. flava and 1. aquaticay;content of all the other heavy metals that occur in the plants that have been collectedfrom the inlets was greater than that of those collected from the outlet, indicating thewetlands' capacity to remove heavy metals from water and sediment through plantuptake.