High Schizotypal Individuals Are More Creative? The Mediation Roles of Overinclusive Thinking and Cognitive Inhibition

Although a theoretical link between positive schizotypy and heightened creativity has been established in the literature, little empirical research has been conducted to examine the underlying cognitive processes that contribute to this association. In addition, previous studies found a negative relationship between positive schizotypy and cognitive inhibition; however, they often used the paradigm of latent inhibition. This study used the paradigm of prepotent response inhibition indicated by Stroop interference effect and examined the mediation effects of overinclusive thinking (OT) and cognitive inhibition on the creativity of schizotypal individuals. Two groups of low and high schizotypal individuals (N = 78) participated in the study. Each participant completed one OT task, one color-word Stroop task, three other executive functioning (EF) control tasks, and two creativity tasks. The results indicated that the high schizotypal group outperformed the low schizotypal group in the creativity tasks. They also exhibited higher OT as indicated by faster reaction time and higher cognitive inhibition as indicated by lower Stroop interference effect. Further, participant’s levels of OT and cognitive inhibition partially mediated the relationship between schizotypy and creativity. The results were discussed under the context of schizotypy and creativity research and implications for rehabitation were further provided

MicroRNA390-Directed TAS3 Cleavage Leads to the Production of tasiRNA-ARF3/4 During Somatic Embryogenesis in Dimocarpus longan Lour

Trans-acting short-interfering RNAs (tasiRNAs) originate from TAS3 families through microRNA (miRNA) 390-guided cleavage of primary transcripts and target auxin response factors (ARF3/-4), which are involved in the normal development of lateral roots and flowers in plants. However, their roles in embryo development are still unclear. Here, the pathway miR390-TAS3-ARF3/-4 was identified systematically for the first time during somatic embryo development in Dimocarpus longan. We identified the miR390 primary transcript and promoter. The promoter contained cis-acting elements responsive to stimuli such as light, salicylic acid, anaerobic induction, fungal elicitor, circadian control and heat stress. The longan TAS3 transcript, containing two miR390-binding sites, was isolated; the miR390- guided cleavage site located near the 3' end of the TAS3 transcript was verified. Eight TAS3-tasiRNAs with the 21-nucleotide phase were found among longan small RNA data, further confirming that miR390-directed TAS3 cleavage leads to the production of tasiRNA in longan. Among them, TAS3_5'D5+ and 5'D6+ tasiRNAs were highly abundant, and verified to target ARF3 and -4, implying that miR390-guided TAS3 cleavage with 21-nucleotide phase leading to the production of tasiRNA-ARF is conserved in plants. Pri-miR390 was highly expressed in friable-embryogenic callus (EC), and less expressed in incomplete compact pro-embryogenic cultures,while miR390 showed its lowest expression in EC and highest expression in torpedo-shaped embryo. DlTAS3 and DlARF4 both exhibited their lowest expressions in EC, and reached their peaks in the globular embryos stage, which were mainly inversely proportional to the expression of miR390, especially at the GE to CE stages. While DlARF3 showed little variation from the EC to torpedo-shaped embryos stages, and exhibited its lowest expression in the cotyledonary embryos stage. There was a general lack of correlation between the expressions of DlARF3 and miR390. In addition, miR390, DlTAS3, DlARF3, and -4 were up-regulated by 2,4-D in a concentration-dependent manner. They were also preferentially expressed in roots, pulp, and seeds of ‘Sijimi’ longan, implying their extended roles in the development of longan roots and fruit. This study provided insights into a possible role of miR390-tasiRNAs-ARF in plant somatic embryo development

Molecular Cloning and Characterization of a P-Glycoprotein from the Diamondback Moth, \u3cem\u3ePlutella xylostella\u3c/em\u3e (Lepidoptera: Plutellidae)

Macrocyclic lactones such as abamectin and ivermectin constitute an important class of broad-spectrum insecticides. Widespread resistance to synthetic insecticides, including abamectin and ivermectin, poses a serious threat to the management of diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), a major pest of cruciferous plants worldwide. P-glycoprotein (Pgp), a member of the ABC transporter superfamily, plays a crucial role in the removal of amphiphilic xenobiotics, suggesting a mechanism for drug resistance in target organisms. In this study, PxPgp1, a putative Pgp gene from P. xylostella, was cloned and characterized. The open reading frame (ORF) of PxPgp1 consists of 3774 nucleotides, which encodes a 1257-amino acid peptide. The deduced PxPgp1 protein possesses structural characteristics of a typical Pgp, and clusters within the insect ABCB1. PxPgp1 was expressed throughout all developmental stages, and showed the highest expression level in adult males. PxPgp1 was highly expressed in midgut, malpighian tubules and testes. Elevated expression of PxPgp1 was observed in P. xylostella strains after they were exposed to the abamectin treatment. In addition, the constitutive expressions of PxPgp1 were significantly higher in laboratory-selected and field-collected resistant strains in comparison to their susceptible counterpart

Robust Representation Learning for Unified Online Top-K Recommendation

In large-scale industrial e-commerce, the efficiency of an online recommendation system is crucial in delivering highly relevant item/content advertising that caters to diverse business scenarios. However, most existing studies focus solely on item advertising, neglecting the significance of content advertising. This oversight results in inconsistencies within the multi-entity structure and unfair retrieval. Furthermore, the challenge of retrieving top-k advertisements from multi-entity advertisements across different domains adds to the complexity. Recent research proves that user-entity behaviors within different domains exhibit characteristics of differentiation and homogeneity. Therefore, the multi-domain matching models typically rely on the hybrid-experts framework with domain-invariant and domain-specific representations. Unfortunately, most approaches primarily focus on optimizing the combination mode of different experts, failing to address the inherent difficulty in optimizing the expert modules themselves. The existence of redundant information across different domains introduces interference and competition among experts, while the distinct learning objectives of each domain lead to varying optimization challenges among experts. To tackle these issues, we propose robust representation learning for the unified online top-k recommendation. Our approach constructs unified modeling in entity space to ensure data fairness. The robust representation learning employs domain adversarial learning and multi-view wasserstein distribution learning to learn robust representations. Moreover, the proposed method balances conflicting objectives through the homoscedastic uncertainty weights and orthogonality constraints. Various experiments validate the effectiveness and rationality of our proposed method, which has been successfully deployed online to serve real business scenarios.Comment: 14 pages, 6 figures, submitted to ICD

The interaction between the PARP10 protein and the NS1 protein of H5N1 AIV and its effect on virus replication

<p>Abstract</p> <p>Background</p> <p>During the process that AIV infect hosts, the NS1 protein can act on hosts, change corresponding signal pathways, promote the translation of virus proteins and result in virus replication.</p> <p>Results</p> <p>In our study, we found that PARP domain and Glu-rich region of PARP10 interacted with NS1, and the presence of NS1 could induce PARP10 migrate from cytoplasm to nucleus. NS1 high expression could reduce the endogenous PARP10 expression. Cell cycle analysis showed that with inhibited PARP10 expression, NS1 could induce cell arrest in G2-M stage, and the percentage of cells in G2-M stage rise from the previous 10%-45%, consistent with the cell proliferation result. Plague forming unit measurement showed that inhibited PARP10 expression could help virus replication.</p> <p>Conclusions</p> <p>In a word, our results showed that NS1 acts on host cells and PARP10 plays a regulating role in virus replication.</p