7,318 research outputs found
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
BRCA2 is a tumor suppressor that functions in homologous recombination, a key genomic integrity pathway. BRCA2 interacts with RAD51, the central protein of recombination, which forms filaments on single-stranded DNA (ssDNA) to perform homology search and DNA strand invasion. We report the purification of full-length human BRCA2 and show that it binds to ~6 RAD51 molecules and promotes RAD51 binding to ssDNA coated by replication protein A (RPA), in a manner that is stimulated by DSS1
High-Resolution Image Synthesis and Semantic Manipulation with Conditional GANs
We present a new method for synthesizing high-resolution photo-realistic
images from semantic label maps using conditional generative adversarial
networks (conditional GANs). Conditional GANs have enabled a variety of
applications, but the results are often limited to low-resolution and still far
from realistic. In this work, we generate 2048x1024 visually appealing results
with a novel adversarial loss, as well as new multi-scale generator and
discriminator architectures. Furthermore, we extend our framework to
interactive visual manipulation with two additional features. First, we
incorporate object instance segmentation information, which enables object
manipulations such as removing/adding objects and changing the object category.
Second, we propose a method to generate diverse results given the same input,
allowing users to edit the object appearance interactively. Human opinion
studies demonstrate that our method significantly outperforms existing methods,
advancing both the quality and the resolution of deep image synthesis and
editing.Comment: v2: CVPR camera ready, adding more results for edge-to-photo example
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