Tidal mixing in the South China Sea : an estimate based on the internal tide energetics

Author Posting. © American Meteorological Society, 2016. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 46 (2016): 107–124, doi:10.1175/JPO-D-15-0082.1.By taking into account the contributions of both locally and remotely generated internal tides, the tidal mixing in the Luzon Strait (LS) and the South China Sea (SCS) is investigated through internal-tide simulation and energetics analysis. A three-dimensional nonhydrostatic high-resolution model driven by four primary tidal constituents (M2, S2, K1, and O1) is used for the internal-tide simulation. The baroclinic energy budget analysis reveals that the internal tides radiated from the LS are the dominant energy source for the tidal dissipation in the SCS. In the LS, the estimated depth-integrated turbulent kinetic energy dissipation exceeds O(1) W m−2 atop the two subsurface ridges, with a dissipation rate of >O(10−7) W kg−1 and diapycnal diffusivity of ~O(10−2) m2 s−1. In the SCS, the most intense turbulence occurs in the deep-water basin with a dissipation rate of O(10−8–10−6) W kg−1 and diapycnal diffusivity of O(10−3–10−1) m2 s−1 within the ~2000-m water column above the seafloor as well as in the shelfbreak region with a dissipation rate of O(10−7–10−6) W kg−1 and diapycnal diffusivity of O(10−4–10−3) m2 s−1. These estimated values are consistent with observations reported in previous studies and are at least one order of magnitude larger than those based solely on locally generated internal tides.This work is jointly supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA11010304, XDA11010204), the MOST of China (2014CB953904), the Knowledge Innovation Program of the Chinese Academy of Sciences (SQ201305), and National Natural Science Foundation of China (41376021, 41306013). ZL’s participation of this work was supported by the National Natural Science Foundation of China (41476006), the Natural Science Foundation of Fujian Province of China (2015J06010), and the National Basic Research Program of China (2012CB417402).2016-07-0

Identification of Circulating Proteins associated With General Cognitive Function among Middle-Aged and Older adults

Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p \u3c 4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance. Enrichment analysis linked the proteins associated with general cognitive function to cell signaling pathways and synapse architecture. Mendelian randomization analysis implicated higher levels of NECTIN2, a protein mediating viral entry into neuronal cells, with higher Alzheimer\u27s disease (AD) risk (p = 2.5E-26). Levels of 14 other protein measures were implicated as consequences of AD susceptibility (p \u3c 2.0E-4). Proteins implicated as causes or consequences of AD susceptibility may provide new insight into the potential relationship between immunity and AD susceptibility as well as potential therapeutic targets

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Plantar Pressure Detection System Based on Flexible Hydrogel Sensor Array and WT-RF

This paper presents a hydrogel-based flexible sensor array to detect plantar pressure distribution and recognize the gait patterns to assist those who suffer from gait disorders to rehabilitate better. The traditional pressure detection array is composed of rigid metal sensors, which have poor biocompatibility and expensive manufacturing costs. To solve the above problems, we have designed and fabricated a novel flexible sensor array based on AAM/NaCl (Acrylamide/Sodium chloride) hydrogel and PI (Polyimide) membrane. The proposed array exhibits excellent structural flexibility (209 KPa) and high sensitivity (12.3 mV·N−1), which allows it to be in full contact with the sole of the foot to collect pressure signals accurately. The Wavelet Transform-Random Forest (WT-RF) algorithm is introduced to recognize the gaits based on the plantar pressure signals. Wavelet transform realizes the signal filtering and normalization, and random forest is responsible for the classification of the processed signals. The classification accuracy of the WT-RF algorithm reaches 91.9%, which ensures the precise recognition of gaits

Anisotropic honeycomb stack metamaterials of graphene for ultrawideband terahertz absorption

Graphene aerogels have implied great potential for electromagnetic wave absorption. However, the investigation of their design for broadband absorption in the terahertz (THz) range remains insufficient. Here, we propose an anisotropic honeycomb stack metamaterial (AHSM) based on graphene to achieve ultrawideband THz absorption. The absorption mechanism is elucidated using the effective medium method, offering deeper physics insights. At low THz frequencies, the impedance matching from the air to the AHSM can be improved by reducing the chemical potential of graphene for high absorption. There is a suppression of absorption at the intermediate frequencies due to constructive interference, which can be avoided by shortening the sizes of honeycomb edges. With the aim to elevate absorption at high frequencies, one can increase the stack layer number to enhance multiple reflections and destructive interference within the metastructure. Based on the above principles, we design an AHSM that achieves a broadband absorbance of over 90 % from 1 THz to 10 THz. This absorption can tolerate a wide range of incident angles for both TE and TM wave excitations. Our research will provide a theoretical guide to future experimental exploration of graphene aerogels for THz metamaterial absorber applications

Metasurface Approach to External Cloak and Designer Cavities

A metasurface, with only a single layer of artificial atoms for ease of fabrication, can become a practical surface-equivalent route to transformation optical (TO) applications. The previous design paradigm for a metasurface carpet cloak is based on straightforward phase compensation, hampering more general wave manipulations. Here, we propose a theoretical approach in designing a metasurface using the concept of complementary media as an intermediate step. The metasurface, effectively storing all the original information in TO media, enables specific TO applications that normally require complementary media. A passive external metasurface cloak is numerically demonstrated here, which can hide an object on top of a reflective metasurface, mimicking a flat mirror. Furthermore, our scheme enables metasurfaces to be used to construct arbitrary standing waves on-demand, which will be useful for constructing tailor-made cavity modes, optical trapping, and illusion-type TO applications, which can project holograms in addition to scattering cancellation

Bioinformatic Analysis of Codon Usage Bias of HSP20 Genes in Four Cruciferous Species

Heat shock protein 20 (HSP20) serves as a chaperone and plays roles in numerous biological processes, but the codon usage bias (CUB) of its genes has remained unexplored. This study identified 140 HSP20 genes from four cruciferous species, Arabidopsis thaliana, Brassica napus, Brassica rapa, and Camelina sativa, that were identified from the Ensembl plants database, and we subsequently investigated their CUB. As a result, the base composition analysis revealed that the overall GC content of HSP20 genes was below 50%. The overall GC content significantly correlated with the constituents at three codon positions, implying that both mutation pressure and natural selection might contribute to the CUB. The relatively high ENc values suggested that the CUB of the HSP20 genes in four cruciferous species was relatively weak. Subsequently, ENc exhibited a negative correlation with gene expression levels. Analyses, including ENc-plot analysis, neutral analysis, and PR2 bias, revealed that natural selection mainly shaped the CUB patterns of HSP20 genes in these species. In addition, a total of 12 optimal codons (ΔRSCU > 0.08 and RSCU > 1) were identified across the four species. A neighbor-joining phylogenetic analysis based on coding sequences (CDS) showed that the 140 HSP20 genes were strictly and distinctly clustered into 12 subfamilies. Principal component analysis and cluster analysis based on relative synonymous codon usage (RSCU) values supported the fact that the CUB pattern was consistent with the genetic relationship at the gene level and (or) species levels. These results will not only enrich the HSP20 gene resource but also advance our understanding of the CUB of HSP20 genes, which may underlie the theoretical basis for exploration of their genetic and evolutionary pattern

Conformal optical black hole for cavity

Whispering gallery mode (WGM) cavity is important for exploring physics of strong light-matter interaction. Yet it suffers from the notorious radiation loss universally due to the light tunneling effect through the curved boundary. In this work, we propose and demonstrate an optical black hole (OBH) cavity based on transformation optics. The radiation loss of all WGMs in OBH cavity is completely inhibited by an infinite wide potential barrier. Besides, the WGM field outside the cavity is revealed to follow $1/r^\alpha$ decay rule based on conformal mapping, which is fundamentally different from the conventional Hankel-function distributions in a homogeneous cavity. Experimentally, a truncated OBH cavity is achieved based on the effective medium theory, and both the Q-factor enhancement and tightly confined WGM field are measured in the microwave spectra which agree well with the theoretical results. The circular OBH cavity is further applied to the arbitrary-shaped cavities including single-core and multi-core structures with high-Q factor via the conformal mapping. The OBH cavity design strategy can be generalized to resonant modes of various wave systems, such as acoustic and elastic waves, and finds applications in energy harvesting and optoelectronics