Table1_A neutrophil extracellular traps-associated lncRNA signature predicts the clinical outcomes in patients with lung adenocarcinoma.docx

Backgrounds: Neutrophil extracellular traps (NETs) play an important role in the occurrence, metastasis, and immune escape of cancers. We aim to investigate Long non-coding RNAs (lncRNAs) that are correlated to NETs to find some potentially useful biomarkers for lung adenocarcinoma (LUAD), and to explore their correlations with immunotherapy and chemotherapy, as well as the tumor microenvironment.Methods: Based on the The Cancer Genome Atlas (TCGA) database, we identified the prognosis-related lncRNAs which are associated with NETs using cox regression. The patients were then separated into two clusters based on the expression of NETs-associated lncRNAs to perform tumor microenvironment analysis and immune-checkpoint analysis. Least absolute shrinkage and selection operator (LASSO) regression was then performed to establish a prognostic signature. Furthermore, nomogram analysis, tumor mutation burden analysis, immune infiltration analysis, as well as drug sensitivity analysis were performed to test the signature.Results: Using univariate cox regression, we found 10 NETs-associated lncRNAs that are associated with the outcomes of LUAD patients. Also, further analysis which separated the patients into 2 clusters showed that the 10 lncRNAs had significant correlations with the tumor microenvironment. Using LASSO regression, we finally constructed a signature to predict the outcomes of the patients based on 4 NETs-associated lncRNAs. The 4 NETs-associated lncRNAs were namely SIRLNT, AL365181.3, FAM83A-AS1, and AJ003147.2. Using Kaplan-Meier (K-M) analysis, we found that the risk model was strongly associated with the survival outcomes of the patients both in the training group and in the validation group 1 and 2 (p Conclusion: We constructed a NETs-associated lncRNA signature to predict the outcome of patients with LUAD, which is associated with immunephenoscores and immune checkpoint-gene expression.</p

Additional file 4 of The complete chloroplast genome of Diplodiscus trichospermus and phylogenetic position of Brownlowioideae within Malvaceae

Additional file 4. The hypothetical tree topologies generated by TreeGraph 2. a Helicteroideae located at the most basal position and Brownlowioideae formed a sister to the clade comprising Tilioideae and Dombeyoideae (present study); b Brownlowioideae and Dombeyoideae formed a sister group and Sterculioideae was close to Malvatheca; c Sterculioideae and Tilioideae formed a close clade which was sister to Malvatheca; d Dombeyoideae formed the earliest divergent clade

Additional file 3 of The complete chloroplast genome of Diplodiscus trichospermus and phylogenetic position of Brownlowioideae within Malvaceae

Additional file 3. The conserved sequences shared among subfamilies. The blue color indicated the sequences located in the IRs

Additional file 1 of The complete chloroplast genome of Diplodiscus trichospermus and phylogenetic position of Brownlowioideae within Malvaceae

Additional file 1. The phylogenetic trees of Malvaceae. Clades are color-coded according to subfamily. a, b and c indicate that ML tree recovered by RAxML, BI tree recovered by MrBayes and ML tree recovered by IQ-TREE 2 respectively. Numbers at each node in a and b indicate the BS and PP values respectively. Numbers at each node in c indicate SH-aLRT support/aBayes support/ultrafast bootstrap supports

Additional file 2 of The complete chloroplast genome of Diplodiscus trichospermus and phylogenetic position of Brownlowioideae within Malvaceae

Additional file 2. The species in Malvaceae covered in dataset. The yellow background indicates the plastome of Diplodiscus trichospermus newly sequenced in this study. Species marked in red font are designated as outer groups

Thermal-Oxidation-Resistant Poly(Carborane-Silane) for Protective Coatings Under Harsh Environments

Thermal-oxidation-resistant polymers are critical for devices/components used under harsh environments where high temperature and an oxidative atmosphere lead to degradation and failure of polymeric parts. Herein, vinyl-containing poly(carborane-silane) (VCP) with good thermal-oxidative stability has been prepared through vinyl-modified m-carborane and silane. The cured VCP (c-VCP) could resist high temperature in both inert and oxidative atmospheres. In comparison to traditional carborane-siloxane copolymers, c-VCP aimed at lowering the oxygen content and simultaneously increasing the boron content, allowing maximum ability to capture oxygen atoms. In an oxidative atmosphere, the formation of the boron oxide layer brought nearly 45% weight gain rather than a weight decrease, which protected the matrix from thermal-oxidative degradation. The mechanism of thermal-oxidative degradation was also investigated based on Flynn–Wall–Ozawa method. The boron oxide layer increased the degradation activation energy (Ea) and hindered direct contact of inner materials with oxygen atoms. When the carbon fibers were coated with c-VCP, the char yield could be increased from 0 to 57 wt % at 1000 °C in air, which demonstrated that c-VCP coating could effectively protect carbon fiber from oxidation at high temperature in air, also indicating potential applications as anti-thermal-oxidative materials for harsh environments

Supplementary document for Wavelength division multiplexing based on coupling effect of helical edge states in two-dimensional dielectric photonic crystals - 6906431.pdf

Supplementary materia

Supplementary document for Wavelength division multiplexing based on coupling effect of helical edge states in two-dimensional dielectric photonic crystals - 6897516.pdf

Supplementary materia

Supplementary document for Wavelength division multiplexing based on coupling effect of helical edge states in two-dimensional dielectric photonic crystals - 6824991.pdf

ID #51892

Supplementary document for Wavelength division multiplexing based on coupling effect of helical edge states in two-dimensional dielectric photonic crystals - 6904649.pdf

Supplementary materia