Transport or Store? Synthesizing Flow-based Microfluidic Biochips using Distributed Channel Storage

Flow-based microfluidic biochips have attracted much atten- tion in the EDA community due to their miniaturized size and execution efficiency. Previous research, however, still follows the traditional computing model with a dedicated storage unit, which actually becomes a bottleneck of the performance of bio- chips. In this paper, we propose the first architectural synthe- sis framework considering distributed storage constructed tem- porarily from transportation channels to cache fluid samples. Since distributed storage can be accessed more efficiently than a dedicated storage unit and channels can switch between the roles of transportation and storage easily, biochips with this dis- tributed computing architecture can achieve a higher execution efficiency even with fewer resources. Experimental results con- firm that the execution efficiency of a bioassay can be improved by up to 28% while the number of valves in the biochip can be reduced effectively.Comment: ACM/IEEE Design Automation Conference (DAC), June 201

Multimedia Semantic Integrity Assessment Using Joint Embedding Of Images And Text

Real world multimedia data is often composed of multiple modalities such as an image or a video with associated text (e.g. captions, user comments, etc.) and metadata. Such multimodal data packages are prone to manipulations, where a subset of these modalities can be altered to misrepresent or repurpose data packages, with possible malicious intent. It is, therefore, important to develop methods to assess or verify the integrity of these multimedia packages. Using computer vision and natural language processing methods to directly compare the image (or video) and the associated caption to verify the integrity of a media package is only possible for a limited set of objects and scenes. In this paper, we present a novel deep learning-based approach for assessing the semantic integrity of multimedia packages containing images and captions, using a reference set of multimedia packages. We construct a joint embedding of images and captions with deep multimodal representation learning on the reference dataset in a framework that also provides image-caption consistency scores (ICCSs). The integrity of query media packages is assessed as the inlierness of the query ICCSs with respect to the reference dataset. We present the MultimodAl Information Manipulation dataset (MAIM), a new dataset of media packages from Flickr, which we make available to the research community. We use both the newly created dataset as well as Flickr30K and MS COCO datasets to quantitatively evaluate our proposed approach. The reference dataset does not contain unmanipulated versions of tampered query packages. Our method is able to achieve F1 scores of 0.75, 0.89 and 0.94 on MAIM, Flickr30K and MS COCO, respectively, for detecting semantically incoherent media packages.Comment: *Ayush Jaiswal and Ekraam Sabir contributed equally to the work in this pape

Testing Microfluidic Fully Programmable Valve Arrays (FPVAs)

Fully Programmable Valve Array (FPVA) has emerged as a new architecture for the next-generation flow-based microfluidic biochips. This 2D-array consists of regularly-arranged valves, which can be dynamically configured by users to realize microfluidic devices of different shapes and sizes as well as interconnections. Additionally, the regularity of the underlying structure renders FPVAs easier to integrate on a tiny chip. However, these arrays may suffer from various manufacturing defects such as blockage and leakage in control and flow channels. Unfortunately, no efficient method is yet known for testing such a general-purpose architecture. In this paper, we present a novel formulation using the concept of flow paths and cut-sets, and describe an ILP-based hierarchical strategy for generating compact test sets that can detect multiple faults in FPVAs. Simulation results demonstrate the efficacy of the proposed method in detecting manufacturing faults with only a small number of test vectors.Comment: Design, Automation and Test in Europe (DATE), March 201

Manganese-Catalyzed Cross-Coupling of Thiols with Aryl Iodides

Here we report the manganesecatalyzedcoupling reaction of thiols witharyl iodides, giving the aryl thioethers ingood to excellent yields; the system showsgood functional group tolerance and enablesthe sterically demanding aryl iodides tocouple with thiols

A General Procedure for the Regioselective Synthesis of Aryl Thioethers and Aryl Selenides Through C–H Activation of Arenes

A general procedure for the synthesis of aryl thioethers and aryl selenides in one-pot through sequential iridium-catalyzed C–H borylation and copper-promoted C–S and C–Se bond formation is described. Functional groups including chloro, nitro, fluoro, trifluoromethyl, and nitrogen-containing heterocycles were all tolerated under the reaction conditions. Importantly, not only aryl thiols and selenides but also their alkyl analogs were suitable coupling partners, and the products were obtained in good yields with high meta regioselectivity

Deep Regionlets for Object Detection

In this paper, we propose a novel object detection framework named "Deep Regionlets" by establishing a bridge between deep neural networks and conventional detection schema for accurate generic object detection. Motivated by the abilities of regionlets for modeling object deformation and multiple aspect ratios, we incorporate regionlets into an end-to-end trainable deep learning framework. The deep regionlets framework consists of a region selection network and a deep regionlet learning module. Specifically, given a detection bounding box proposal, the region selection network provides guidance on where to select regions to learn the features from. The regionlet learning module focuses on local feature selection and transformation to alleviate local variations. To this end, we first realize non-rectangular region selection within the detection framework to accommodate variations in object appearance. Moreover, we design a "gating network" within the regionlet leaning module to enable soft regionlet selection and pooling. The Deep Regionlets framework is trained end-to-end without additional efforts. We perform ablation studies and conduct extensive experiments on the PASCAL VOC and Microsoft COCO datasets. The proposed framework outperforms state-of-the-art algorithms, such as RetinaNet and Mask R-CNN, even without additional segmentation labels.Comment: Accepted to ECCV 201