A General Framework for Complex Network Applications

Complex network theory has been applied to solving practical problems from different domains. In this paper, we present a general framework for complex network applications. The keys of a successful application are a thorough understanding of the real system and a correct mapping of complex network theory to practical problems in the system. Despite of certain limitations discussed in this paper, complex network theory provides a foundation on which to develop powerful tools in analyzing and optimizing large interconnected systems.Comment: 8 page

Satellite Broadcasting Enabled Blockchain Protocol: A Preliminary Study

Low throughput has been the biggest obstacle of large-scale blockchain applications. During the past few years, researchers have proposed various schemes to improve the systems' throughput. However, due to the inherent inefficiency and defects of the Internet, especially in data broadcasting tasks, these efforts all rendered unsatisfactory. In this paper, we propose a novel blockchain protocol which utilizes the satellite broadcasting network instead of the traditional Internet for data broadcasting and consensus tasks. An automatic resumption mechanism is also proposed to solve the unique communication problems of satellite broadcasting. Simulation results show that the proposed algorithm has a lower communication cost and can greatly improve the throughput of the blockchain system. Theoretical estimation of a satellite broadcasting enabled blockchain system's throughput is 6,000,000 TPS with a 20 gbps satellite bandwidth.Comment: Accepted by 2020 Information Communication Technologies Conference (ICTC 2020

Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells.

Experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), is characterized by CNS demyelination mediated by autoreactive T cells. Kirenol, a biologically active substance isolated from Herba Siegesbeckiae, has potent anti-inflammatory activities. Here we investigated effects of kirenol on EAE. Kirenol treatment markedly delayed onset of disease and reduced clinical scores in EAE mice. Kirenol treatment reduced expression of IFN-γ and IL-17A in the serum and proportion of Th1 and Th17 cells in draining lymph nodes. Priming of lymphocytes was reduced and apoptosis of MOG-activated CD4+ T cells was increased in kirenol treated EAE mice. Kirenol treatment of healthy animals did not affect the lymphocytes in these non-immunized mice. Further in vitro studies showed that kirenol inhibited viability of MOG-specific lymphocytes and induced apoptosis of MOG-specific CD4+ T cells in a dose- and time-dependent manner. Kirenol treatment upregulated Bax,downregulated Bcl-2,and increased activation of caspase-3 and release of cytochrome c, indicating that a mitochondrial pathway was involved in kirenol induced apoptosis. Moreover, pretreatment with either a pan-caspase inhibitor z-VAD-fmk or a more specific caspase 3 inhibitor Ac-DEVD-CHO in lymphocytes reduced kirenol induced apoptosis. Our findings implicate kirenol as a useful agent for the treatment of MS

The value of additional reviews in reputation systems: Evidence from a car review platform

Online reviews, especially additional reviews, have become an important channel for consumers to obtain information about product quality. Based on review data obtained from “AutoHome”, which is a most popular car review platform in China, this study explores the influence of additional review function on the initial reviews from both the reader and reviewer levels. At the reader-level, the introduction of the additional review function improves readers’ perceived usefulness of the reviews. At the reviewer-level, it can drive reviewers to write more initial reviews. In general, the introduction of such a function can be regarded as an improvement of the existing review mechanism. The findings of this study can not only enrich the research on online word-of-mouth, but also provide valuable reference for related practitioners