A VMiPG method for composite optimization with nonsmooth term having no closed-form proximal mapping

This paper concerns the minimization of the sum of a twice continuously differentiable function $f$ and a nonsmooth convex function $g$ without closed-form proximal mapping. For this class of nonconvex and nonsmooth problems, we propose a line-search based variable metric inexact proximal gradient (VMiPG) method with uniformly bounded positive definite variable metric linear operators. This method computes in each step an inexact minimizer of a strongly convex model such that the difference between its objective value and the optimal value is controlled by its squared distance from the current iterate, and then seeks an appropriate step-size along the obtained direction with an armijo line-search criterion. We prove that the iterate sequence converges to a stationary point when $f$ and $g$ are definable in the same o-minimal structure over the real field $(\mathbb{R},+,\cdot)$, and if addition the objective function $f+g$ is a KL function of exponent $1/2$, the convergence has a local R-linear rate. The proposed VMiPG method with the variable metric linear operator constructed by the Hessian of the function $f$ is applied to the scenario that $f$ and $g$ have common composite structure, and numerical comparison with a state-of-art variable metric line-search algorithm indicates that the Hessian-based VMiPG method has a remarkable advantage in terms of the quality of objective values and the running time for those difficult problems such as high-dimensional fused weighted-lasso regressions

An inexact qq-order regularized proximal Newton method for nonconvex composite optimization

This paper concerns the composite problem of minimizing the sum of a twice continuously differentiable function $f$ and a nonsmooth convex function. For this class of nonconvex and nonsmooth problems, by leveraging a practical inexactness criterion and a novel selection strategy for iterates, we propose an inexact $q\in[2,3]$-order regularized proximal Newton method, which becomes an inexact cubic regularization (CR) method for $q=3$. We justify that its iterate sequence converges to a stationary point for the KL objective function, and if the objective function has the KL property of exponent $\theta\in(0,\frac{q-1}{q})$, the convergence has a local $Q$-superlinear rate of order $\frac{q-1}{\theta q}$. In particular, under a locally H\"{o}lderian error bound of order $\gamma\in(\frac{1}{q-1},1]$ on a second-order stationary point set, the iterate sequence converges to a second-order stationary point with a local $Q$-superlinear rate of order $\gamma(q\!-\!1)$, which is specified as $Q$-quadratic rate for $q=3$ and $\gamma=1$. This is the first practical inexact CR method with $Q$-quadratic convergence rate for nonconvex composite optimization. We validate the efficiency of the proposed method with ZeroFPR as the solver of subproblems by applying it to convex and nonconvex composite problems with a highly nonlinear $f$

CRISPR accelerates the cancer drug discovery

Emerging cohorts and basic studies have associated certain genetic modifications in cancer patients, such as gene mutation, amplification, or deletion, with the overall survival prognosis, underscoring patients??? genetic background may directly regulate drug sensitivity/resistance during chemotherapies. Understanding the molecular mechanism underpinning drug sensitivity/resistance and further uncovering the effective drugs have been the major ambition in the cancer drug discovery. The emergence and popularity of CRISPR/Cas9 technology have reformed the entire life science research, providing a precise and simplified genome editing tool with unlimited editing possibilities. Furthermore, it presents a powerful tool in cancer drug discovery, which hopefully facilitates us with a rapid and reliable manner in developing novel therapies and understanding the molecular mechanisms of drug sensitivity/resistance. Herein, we summarized the application of CRISPR/Cas9 in drug screening, with the focus on CRISPR/Cas9 mediated gene knockout, gene knock-in, as well as transcriptional modification. Additionally, this review provides the concerns, cautions, and ethnic considerations that need to be taken when applying CRISPR in the drug discovery.Peer reviewe

An inexact linearized proximal algorithm for a class of DC composite optimization problems and applications

This paper is concerned with a class of DC composite optimization problems which, as an extension of the convex composite optimization problem and the DC program with nonsmooth components, often arises from robust factorization models of low-rank matrix recovery. For this class of nonconvex and nonsmooth problems, we propose an inexact linearized proximal algorithm (iLPA) which in each step computes an inexact minimizer of a strongly convex majorization constructed by the partial linearization of their objective functions. The generated iterate sequence is shown to be convergent under the Kurdyka-{\L}ojasiewicz (KL) property of a potential function, and the convergence admits a local R-linear rate if the potential function has the KL property of exponent $1/2$ at the limit point. For the latter assumption, we provide a verifiable condition by leveraging the composite structure, and clarify its relation with the regularity used for the convex composite optimization. Finally, the proposed iLPA is applied to a robust factorization model for matrix completions with outliers, DC programs with nonsmooth components, and $\ell_1$-norm exact penalty of DC constrained programs, and numerical comparison with the existing algorithms confirms the superiority of our iLPA in computing time and quality of solutions

An inexact regularized proximal Newton method for nonconvex and nonsmooth optimization

This paper focuses on the minimization of a sum of a twice continuously differentiable function $f$ and a nonsmooth convex function. We propose an inexact regularized proximal Newton method by an approximation of the Hessian $\nabla^2\!f(x)$ involving the $\varrho$th power of the KKT residual. For $\varrho=0$, we demonstrate the global convergence of the iterate sequence for the KL objective function and its $R$-linear convergence rate for the KL objective function of exponent $1/2$. For $\varrho\in(0,1)$, we establish the global convergence of the iterate sequence and its superlinear convergence rate of order $q(1\!+\!\varrho)$ under an assumption that cluster points satisfy a local H\"{o}lderian local error bound of order $q\in(\max(\varrho,\frac{1}{1+\varrho}),1]$ on the strong stationary point set; and when cluster points satisfy a local error bound of order $q>1+\varrho$ on the common stationary point set, we also obtain the global convergence of the iterate sequence, and its superlinear convergence rate of order $\frac{(q-\varrho)^2}{q}$ if $q>\frac{2\varrho+1+\sqrt{4\varrho+1}}{2}$. A dual semismooth Newton augmented Lagrangian method is developed for seeking an inexact minimizer of subproblem. Numerical comparisons with two state-of-the-art methods on $\ell_1$-regularized Student's $t$-regression, group penalized Student's $t$-regression, and nonconvex image restoration confirm the efficiency of the proposed method

Privacy-preserving Inference of Group Mean Difference in Zero-inflated Right Skewed Data with Partitioning and Censoring

We examine privacy-preserving inferences of group mean differences in zero-inflated right-skewed (zirs) data. Zero inflation and right skewness are typical characteristics of ads clicks and purchases data collected from e-commerce and social media platforms, where we also want to preserve user privacy to ensure that individual data is protected. In this work, we develop likelihood-based and model-free approaches to analyzing zirs data with formal privacy guarantees. We first apply partitioning and censoring (PAC) to ``regularize'' zirs data to get the PAC data. We expect inferences based on PAC to have better inferential properties and more robust privacy considerations compared to analyzing the raw data directly. We conduct theoretical analysis to establish the MSE consistency of the privacy-preserving estimators from the proposed approaches based on the PAC data and examine the rate of convergence in the number of partitions and privacy loss parameters. The theoretical results also suggest that it is the sampling error of PAC data rather than the sanitization error that is the limiting factor in the convergence rate. We conduct extensive simulation studies to compare the inferential utility of the proposed approach for different types of zirs data, sample size and partition size combinations, censoring scenarios, mean differences, privacy budgets, and privacy loss composition schemes. We also apply the methods to obtain privacy-preserving inference for the group mean difference in a real digital ads click-through data set. Based on the theoretical and empirical results, we make recommendations regarding the usage of these methods in practice

Efficient approximation of Earth Mover's Distance Based on Nearest Neighbor Search

Earth Mover's Distance (EMD) is an important similarity measure between two distributions, used in computer vision and many other application domains. However, its exact calculation is computationally and memory intensive, which hinders its scalability and applicability for large-scale problems. Various approximate EMD algorithms have been proposed to reduce computational costs, but they suffer lower accuracy and may require additional memory usage or manual parameter tuning. In this paper, we present a novel approach, NNS-EMD, to approximate EMD using Nearest Neighbor Search (NNS), in order to achieve high accuracy, low time complexity, and high memory efficiency. The NNS operation reduces the number of data points compared in each NNS iteration and offers opportunities for parallel processing. We further accelerate NNS-EMD via vectorization on GPU, which is especially beneficial for large datasets. We compare NNS-EMD with both the exact EMD and state-of-the-art approximate EMD algorithms on image classification and retrieval tasks. We also apply NNS-EMD to calculate transport mapping and realize color transfer between images. NNS-EMD can be 44x to 135x faster than the exact EMD implementation, and achieves superior accuracy, speedup, and memory efficiency over existing approximate EMD methods

LAPTM4B-35 promotes cancer cell migration via stimulating integrin beta1 recycling and focal adhesion dynamics

Metastasis is the main cause of cancer patients' death despite tremendous efforts invested in developing the related molecular mechanisms. During cancer cell migration, cells undergo dynamic regulation of filopodia, focal adhesion, and endosome trafficking. Cdc42 is imperative for maintaining cell morphology and filopodia, regulating cell movement. Integrin beta1 activates on the endosome, the majority of which distributes itself on the plasma membrane, indicating that endocytic trafficking is essential for this activity. In cancers, high expression of lysosome-associated protein transmembrane 4B (LAPTM4B) is associated with poor prognosis. LAPTM4B-35 has been reported as displaying plasma membrane distribution and being associated with cancer cell migration. However, the detailed mechanism of its isoform-specific distribution and whether it relates to cell migration remain unknown. Here, we first report and quantify the filopodia localization of LAPTM4B-35: mechanically, that specific interaction with Cdc42 promoted its localization to the filopodia. Furthermore, our data show that LAPTM4B-35 stabilized filopodia and regulated integrin beta1 recycling via interaction and cotrafficking on the endosome. In our zebrafish xenograft model, LAPTM4B-35 stimulated the formation and dynamics of focal adhesion, further promoting cancer cell dissemination, whereas in skin cancer patients, LAPTM4B level correlated with poor prognosis. In short, this study establishes an insight into the mechanism of LAPTM4B-35 filopodia distribution, as well as into its biological effects and its clinical significance, providing a novel target for cancer therapeutics development.Peer reviewe

360ORB-SLAM: A Visual SLAM System for Panoramic Images with Depth Completion Network

To enhance the performance and effect of AR/VR applications and visual assistance and inspection systems, visual simultaneous localization and mapping (vSLAM) is a fundamental task in computer vision and robotics. However, traditional vSLAM systems are limited by the camera's narrow field-of-view, resulting in challenges such as sparse feature distribution and lack of dense depth information. To overcome these limitations, this paper proposes a 360ORB-SLAM system for panoramic images that combines with a depth completion network. The system extracts feature points from the panoramic image, utilizes a panoramic triangulation module to generate sparse depth information, and employs a depth completion network to obtain a dense panoramic depth map. Experimental results on our novel panoramic dataset constructed based on Carla demonstrate that the proposed method achieves superior scale accuracy compared to existing monocular SLAM methods and effectively addresses the challenges of feature association and scale ambiguity. The integration of the depth completion network enhances system stability and mitigates the impact of dynamic elements on SLAM performance.Comment: 6 pages, 9 figure