Dibromidobis(N,N-diethyl­dithio­carbamato-κ2 S,S′)tetra-μ3-sulfido-dicopper(I)dimolybdenum(V) isopropanol disolvate

The mol­ecule of the title compound, [Cu2Mo2Br2(C7H14NS2)2S4]·2C3H7OH, comprises one [(i-C3H7)2NCS2]2Mo2S4 unit and two CuBr units held together by six Cu—μ3-S bonds, thus forming a cubane-like Mo2S4Cu2 core. Intramolecular O—H⋯S hydrogen bonds may stabilize the structure. Two methyl groups of the two independent solvent molecules are disordered over two positions and were refined with occupancies of 0.733 (12) and 0.267 (12)

Staphylococcal peptidoglycans induce arthritis

Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus