Annotation-based meta-analysis of microarray experiments

We are developing software applications to perform meta-analysis of microarray experiments based on standardized experiment annotations aiming to identify similar experiments and cluster experiments. The applications were tested on files obtained from the ArrayExpress public repository. Annotation terms were used to compute experiment dissimilarities to find experiments related to a query experiment. These applications may motivate efforts of bench biologists to better annotate experiments

Observation of sub-Doppler absorption in the /Lambda-type three-level Doppler-broadened cesium system

Thanks to the atomic coherence in coupling laser driven atomic system, sub-Doppler absorption has been observed in Doppler-broadened cesium vapor cell via the /Lambda-type three-level scheme. The linewidth of the sub-Doppler absorption peak become narrower while the frequency detuning of coupling laser increases. The results are in agreement with the theoretical prediction by G. Vemuri et al.[PRA,Vol.53(1996) p.2842].Comment: 12 pages, 5 figures, to appear on Applied Physics

TRÉMON, Anne-Christine. 2022. Diaspora Space-time: Transformations of a Chinese Emigrant Community. Ithaca: Cornell University Press.

Despite the unprecedented success of Shenzhen in China’s economic development, there has been a conspicuous lack of academic attention devoted to the city. While the prevailing narratives of the Shenzhen phenomenon primarily highlight the top-down policies and initiatives of the central government, grassroots-level sociocultural negotiations undertaken by local communities have also been instrumental in shaping the city’s trajectory. In particular, rural villages such as Pine Mansion have bee..

Theoretical study of the folding kinetics of the ultra-fast folding Trp-cage protein

Native-centric coarse-gained models, termed Ca Go models, have been widely used for computational simulation of small protein to study their folding kinetics and thermodynamics. The limitations of these models come from the lack of non-native interactions and neglect of the specificity of amino acid residues. On the other hand, the simulations of protein folding in atomistic details using accurate energy force field, termed ab-initio models, have been proven to be too computationally expensive, even with the most powerful computers. Therefore, many new models at intermediate level have been developed, such as multi-bead model, Go-like model, and all-atom Go model. These improved Go-like models retain some of the specificity of amino acids and more importantly are still able to fold proteins starting from completely unfolded states to their unique native structures