2,352 research outputs found
Global homeomorphism theorem for manifolds and polyhedra
We improved a version of Global Homeomorphism Theorem due to Katriel such that it can be applied to more general geometric objects: Hilbert Riemannian manifolds, graphs, and polyhedra.Mathematics, AppliedMathematicsSCI(E)0ARTICLE97-10610
Kinetic behavior of the general modifier mechanism of Botts and Morales with non-equilibrium binding
In this paper, we perform a complete analysis of the kinetic behavior of the
general modifier mechanism of Botts and Morales in both equilibrium steady
states and non-equilibrium steady states (NESS). Enlightened by the
non-equilibrium theory of Markov chains, we introduce the net flux into
discussion and acquire an expression of product rate in NESS, which has clear
biophysical significance. Up till now, it is a general belief that being an
activator or an inhibitor is an intrinsic property of the modifier. However, we
reveal that this traditional point of view is based on the equilibrium
assumption. A modifier may no longer be an overall activator or inhibitor when
the reaction system is not in equilibrium. Based on the regulation of enzyme
activity by the modifier concentration, we classify the kinetic behavior of the
modifier into three categories, which are named hyperbolic behavior,
bell-shaped behavior, and switching behavior, respectively. We show that the
switching phenomenon, in which a modifier may convert between an activator and
an inhibitor when the modifier concentration varies, occurs only in NESS.
Effects of drugs on the Pgp ATPase activity, where drugs may convert from
activators to inhibitors with the increase of the drug concentration, are taken
as a typical example to demonstrate the occurrence of the switching phenomenon.Comment: 19 pages, 10 figure
[2-({Benzyl[2-(benzyl{5-methyl-2-oxido-3-[(pyridin-2-ylmethyl)iminomethyl]benzyl}amino)ethyl]azaniumyl}methyl)-4-methyl-6-[(pyridin-2-ylmethyl)iminomethyl]phenolato]nickel(II) perchlorate methanol disolvate
In the solvated title complex, [Ni(C46H47N6O2)]ClO4·2CH4O, the coordination sphere around the NiII ion can be described as distorted cis-NiO2N4 octahedral defined by two phenolate O atoms and four N atoms from the hexadentate ligand. An intramolecular bifurcated N—H⋯(N,O) hydrogen bond helps to establish the conformation of the complex molecule. In the crystal, the components are connected by O—H⋯O and C—H⋯O hydrogen bonds
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