Cognitive deficits in sleep apnea: A meta-analysis

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Executive Control In Depressive Rumination: Backward Inhibition And Non-inhibitory Switching Performance In A Modified Mixed Antisaccade Task

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Wind noise spectra in small Reynolds number turbulent flows

© 2017 Acoustical Society of America. Wind noise spectra caused by wind from fans in indoor environments have been found to be different from those measured in outdoor atmospheric conditions. Although many models have been developed to predict outdoor wind noise spectra under the assumption of large Reynolds number [Zhao, Cheng, Qiu, Burnett, and Liu (2016). J. Acoust. Soc. Am. 140, 4178-4182, and the references therein], they cannot be applied directly to the indoor situations because the Reynolds number of wind from fans in indoor environments is usually much smaller than that experienced in atmospheric turbulence. This paper proposes a pressure structure function model that combines the energy-containing and dissipation ranges so that the pressure spectrum for small Reynolds number turbulent flows can be calculated. The proposed pressure structure function model is validated with the experimental results in the literature, and then the obtained pressure spectrum is verified with the numerical simulation and experiment results. It is demonstrated that the pressure spectrum obtained from the proposed pressure structure function model can be utilized to estimate wind noise spectra caused by turbulent flows with small Reynolds numbers

Pressure spectra in turbulent flows in the inertial and the dissipation ranges

© 2016 Acoustical Society of America. Based on existing studies that provide the pressure spectra in turbulent flows from the asymptotic pressure structure function in the inertial range, this paper extends the pressure spectrum to the dissipation range by proposing a pressure structure function model that incorporates both the inertial and dissipation ranges. Existing experiment results were used to validate the proposed pressure structure function model first, and then the obtained pressure spectrum was compared with the simulation and measurement data in the literature and the wind-induced noise measured outdoors. All comparisons demonstrate that the pressure spectrum obtained from the proposed pressure structure function model can be used to estimate the pressure spectra in both the inertial and dissipation ranges in turbulent flows with a sufficiently large Reynolds number

Estimation of the frequency boundaries of the inertial range for wind noise spectra in anechoic wind tunnels

Wind noise generated by the intrinsic turbulence in the flow can affect outdoor noise measurements. Various attempts have been made to investigate the wind noise generation mechanism. Wind noise spectra in anechoic wind tunnels can be divided into three frequency regions: In the low frequency region known as the energy-containing range, the wind noise spectrum does not change significantly with frequency. In contrast, in the middle frequency region (or inertial range) the decay rate of the wind noise spectrum curve follows the -7/3 power law, but in the high frequency region (or dissipation range) the decay rate of the wind noise spectrum curve is faster than the -7/3 power law. The boundaries of the -7/3 power law frequency range depend on the Reynolds number; however, no exact value is known according to current literature. This paper proposes a method for predicting the boundary values based on the energy cascade theory. Large eddy simulations of free jet were performed to validate the proposed method and the results were found to be in reasonable agreement with existing experiment measurements obtained in an anechoic wind tunnel. Additional simulations were also conducted with different inflow entrance sizes to further verify the predictions from the proposed method

On the wind noise reduction mechanism of porous microphone windscreens

© 2017 Acoustical Society of America. This paper investigates the wind noise reduction mechanism of porous microphone windscreens. The pressure fluctuations inside the porous windscreens with various viscous and inertial coefficients are studied with numerical simulations. The viscous and inertial coefficients represent the viscous forces resulting from the fluid-solid interaction along the surface of the pores and the inertial forces imposed on the fluid flow by the solid structure of the porous medium, respectively. Simulation results indicate that the wind noise reduction first increases and then decreases with both viscous and inertial coefficients after reaching a maximum. Experimental results conducted on five porous microphone windscreens with porosity from 20 to 60 pores per inch (PPI) show that the 40 PPI windscreen has the highest wind noise reduction performance, and this supports the simulation results. The existence of the optimal values for the viscous and inertial coefficients is explained qualitatively and it is shown that the design of the porous microphone windscreens should take into account both the turbulence suppression inside and the wake generation behind the windscreen to achieve optimal performance

Mitigating wind noise with a spherical microphone array

© 2018 Acoustical Society of America. This paper utilizes a rigid spherical microphone array to reduce wind noise. In the experiments conducted, a loudspeaker is used to reproduce the desired sound signal and an axial fan is employed to generate wind noise in an anechoic chamber. The sound signal and wind noise are measured separately with the spherical microphone array and analyzed in the spherical harmonic domain. The wind noise is found to be irregularly distributed in the spherical harmonic domain, distinct from the sound signal which is concentrated in the first few spherical harmonic modes. This difference is utilized to reduce wind noise without degrading the desired sound pressure level (SPL) by use of a low pass filter method in the spherical harmonic domain. Experimental results with both single-tonal and multi-tonal sound signals demonstrate that the proposed method can reduce wind noise by more than 10 dB in the frequency range below 500 Hz. The SPL of the desired sound signal can be extracted from wind noise with an error within 1.0 dB, even when the sound level is 8 dB lower than wind noise

Occult alpha globin gene mutations are the commonest causes of red cell microcytosis unexplained by phenotypic testing

HAA: Haematology Society of Australia and New Zealand, The Australian & New Zealand Society of Blood Transfusion and The Australasian Society of Thrombosis and HaemostasisAIM: Hypochromic microcytic anaemia is the hallmark phenotype of thalassaemia. Current phenotypic tests do not provide a diagnosis in a small proportion of patients with red cell microcytosis. We investigated the genetic basis of microcytosis in a cohort of such subjects. METHOD: We identified from a large cohort of 1684 unselected requests for thalassaemia testing 25 Chinese subjects who had unexplained microcytosis after phenotypic haemoglobin studies. Extensive genotypic analysis of the α and β globin gene cluster was performed in 20 of these subjects who had adequate DNA. Techniques employed included gap-polymerase chain reaction, amplification-refractory mutation system, Sanger sequencing and multiplex ligation-dependent …postprin

Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome

Clinical outcome and mutations of 96 core-binding factor acute myeloid leukemia (AML) patients 18-60 years old were examined. Complete remission (CR) after induction was 94.6%. There was no significant difference in CR, leukemia-free-survival (LFS) and overall survival (OS) between t(8;21) (N=67) and inv(16) patients (N=29). Univariate analysis showed hematopoietic stem cell transplantation at CR1 as the only clinical parameter associated with superior LFS. Next-generation sequencing based on a myeloid gene panel was performed in 72 patients. Mutations in genes involved in cell signaling were associated with inferior LFS and OS, whereas those in genes involved in DNA methylation were associated with inferior LFS. KIT activation loop (AL) mutations occurred in 25 patients, and were associated with inferior LFS (P=0.003) and OS (P=0.001). TET2 mutations occurred in 8 patients, and were associated with significantly shorter LFS (P=0.015) but not OS. Patients negative for KIT-AL and TET2 mutations (N=41) had significantly better LFS (P<0.001) and OS (P=0.012) than those positive for both or either mutation. Multivariate analysis showed that KIT-AL and TET2 mutations were associated with inferior LFS, whereas age ⩾40 years and marrow blast ⩾70% were associated with inferior OS. These observations provide new insights that may guide better treatment for this AML subtype.published_or_final_versio