Phase coherence phenomena in superconducting films

Superconducting films subject to an in-plane magnetic field exhibit a gapless superconducting phase. We explore the quasi-particle spectral properties of the gapless phase and comment on the transport properties. Of particular interest is the sensitivity of the quantum interference phenomena in this phase to the nature of the impurity scattering. We find that films subject to columnar defects exhibit a `Berry-Robnik' symmetry which changes the fundamental properties of the system. Furthermore, we explore the integrity of the gapped phase. As in the magnetic impurity system, we show that optimal fluctuations of the random impurity potential conspire with the in-plane magnetic field to induce a band of localized sub-gap states. Finally, we investigate the interplay of the proximity effect and gapless superconductivity in thin normal metal-superconductor bi-layers.Comment: 13 pages, 8 figures include

Expanding access to coronary artery bypass surgery: who stands to gain

OBJECTIVE--To determine the perceptions of general practitioners (GPs) about the benefits of coronary artery bypass surgery, in terms of gains in life expectancy, for different groups of patients. DESIGN--A questionnaire survey of all GPs in Northern Ireland. SETTING--A survey conducted collaboratively by the departments of public health medicine in each of the four health boards in the province, serving a total population of 1.5 million. MAIN OUTCOME MEASURES--The median and mean gain in life expectancy perceived by groups of doctors for smoking and non-smoking male and female 55 year old patients. The percentage of 50 year old and 70 year old non-smoking patients considered likely to have their lives extended with bypass surgery. Differences were assessed using the Mann-Whitney U test for unpaired samples and the Wilcoxon signed rank tests for paired. RESULTS--541 GPs replied (response rate 56%). The median (and mean) perceived gain in life expectancy after cardiac surgery for non-smoking 55 year old subjects was 120 (104) months for men and 120 (112) months for women (z = 6.42; P < 0.0001; Wilcoxon signed rank test). For male and female smokers of the same age, the perceived gains were 48 (47) and 60 (52) months respectively (z = 6.72; P < 0.0001; Wilcoxon signed ranks test), both figures being significantly different than for non-smokers. The median (and mean) percentage of patients that the doctors considered would have their lives extended by bypass surgery was 70 (64) of every 100 "young" patients and 40 (42) of every 100 "old" patients, (z = 16.2; P < 0.0001). CONCLUSIONS--These results point to a significant overestimation of the benefits of coronary artery bypass surgery by GPs in Northern Ireland and to a need to develop guidelines for referral

Evaluating oribi translocations for conservation : the importance of translocation guidelines

At a global scale, anthropogenically-mediated disturbances have resulted in the extirpation of species and declines in both population and range size. Furthermore, land transformation and habitat fragmentation have limited the ability of species to disperse naturally throughout their ranges. To compensate for both this defaunation and disruption of animal movement patterns, rewilding and restoration are becoming increasingly important approaches to conserve and promote biodiversity. Central to both of these concepts, as well as wildlife management and conservation in general, is the translocation of species.The National Research Foundation (90783), the Endangered Wildlife Trust, and a Gay Langmuir bursary from the University of KwaZulu-Natal.https://sawma.co.za/african-journal-of-wildlife-researcham2022Mammal Research InstituteZoology and Entomolog

Electronic Collective Modes and Superconductivity in Layered Conductors

A distinctive feature of layered conductors is the presence of low-energy electronic collective modes of the conduction electrons. This affects the dynamic screening properties of the Coulomb interaction in a layered material. We study the consequences of the existence of these collective modes for superconductivity. General equations for the superconducting order parameter are derived within the strong-coupling phonon-plasmon scheme that account for the screened Coulomb interaction. Specifically, we calculate the superconducting critical temperature Tc taking into account the full temperature, frequency and wave-vector dependence of the dielectric function. We show that low-energy plasmons may contribute constructively to superconductivity. Three classes of layered superconductors are discussed within our model: metal-intercalated halide nitrides, layered organic materials and high-Tc oxides. In particular, we demonstrate that the plasmon contribution (electronic mechanism) is dominant in the first class of layered materials. The theory shows that the description of so-called ``quasi-two-dimensional superconductors'' cannot be reduced to a purely 2D model, as commonly assumed. While the transport properties are strongly anisotropic, it remains essential to take into account the screened interlayer Coulomb interaction to describe the superconducting state of layered materials.Comment: Final version (minor changes) 14 pages, 6 figure

Surface superconducting states and paramagnetism in mesoscopic superconductors

In the framework of the Ginzburg-Landau equation, the temperature dependence of the upper critical field of small ring-like superconductors is studied. At equilibrium small parts of the phase diagram show paramagnetism for width / radius ratios below 0.85. Their number and extension increase with the size of the hole. In these regions, only the inner part of the ring shows a positive magnetic moment. The order parameter density profile appears to change, when crossing a first order transition line, which separates different angular momentum values, and we clarify the relationship between the localization of superconductivity nucleation and paramagnetism of those samples.Comment: 11 pages, 9 figure

LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases

Purpose: HER2 + breast cancer (BC) is an aggressive subtype with high rates of brain metastases (BCBM). Two-thirds of HER2 + BCBM demonstrate activation of the PI3K/mTOR pathway driving resistance to anti-HER2 therapy. This phase II study evaluated everolimus (E), a brain-permeable mTOR inhibitor, trastuzumab (T), and vinorelbine (V) in patients with HER2 + BCBM. Patients and methods: Eligible patients had progressive HER2 + BCBM. The primary endpoint was intracranial response rate (RR); secondary objectives were CNS clinical benefit rate (CBR), extracranial RR, time to progression (TTP), overall survival (OS), and targeted sequencing of tumors from enrolled patients. A two-stage design distinguished intracranial RR of 5% versus 20%. Results: 32 patients were evaluable for toxicity, 26 for efficacy. Intracranial RR was 4% (1 PR). CNS CBR at 6 mos was 27%; at 3 mos 65%. Median intracranial TTP was 3.9 mos (95% CI 2.2–5). OS was 12.2 mos (95% CI 0.6–20.2). Grade 3–4 toxicities included neutropenia (41%), anemia (16%), and stomatitis (16%). Mutations in TP53 and PIK3CA were common in BCBM. Mutations in the PI3K/mTOR pathway were not associated with response. ERBB2 amplification was higher in BCBM compared to primary BC; ERBB2 amplification in the primary BC trended toward worse OS. Conclusion: While intracranial RR to ETV was low in HER2 + BCBM patients, one-third achieved CNS CBR; TTP/OS was similar to historical control. No new toxicity signals were observed. Further analysis of the genomic underpinnings of BCBM to identify tractable prognostic and/or predictive biomarkers is warranted. Clinical Trial: (NCT01305941)

In-beam γ -ray spectroscopy of Fe 68 from charge exchange on Co 68 projectiles

Excited states in the neutron-rich nucleus Fe68 were populated using a Be9(Co68, 68Fe+γ)X charge-exchange reaction at 95 MeV/u. The new γ-ray transitions reported here for the first time complement data from β-decay studies and nucleon knockout reactions. In comparison to shell-model calculations with the LNPS effective interaction, two candidate states for the 61+ level emerge. The distinct population pattern of excited states and the magnitude of the cross section, σinc=0.51(6) mb, make this reaction a promising one for future in-beam γ-ray spectroscopy. Reaction calculations with nuclear structure input from a new, locally optimized Hamiltonian, f7j4a, together with general considerations for heavy-ion-induced charge-exchange reactions appear consistent with most of the observations, although challenges remain

Discriminating instance generation for automated constraint model selection

One approach to automated constraint modelling is to generate, and then select from, a set of candidate models. This method is used by the automated modelling system Conjure. To select a preferred model or set of models for a problem class from the candidates Conjure produces, we use a set of training instances drawn from the target class. It is important that the training instances are discriminating. If all models solve a given instance in a trivial amount of time, or if no models solve it in the time available, then the instance is not useful for model selection. This paper addresses the task of generating small sets of discriminating training instances automatically. The instance space is determined by the parameters of the associated problem class. We develop a number of methods of finding parameter configurations that give discriminating training instances, some of them leveraging existing parameter-tuning techniques. Our experimental results confirm the success of our approach in reducing a large set of input models to a small set that we can expect to perform well for the given problem class

In-beam γ-ray spectroscopy of Cr 62,64

The region of neutron-rich Cr isotopes has garnered much attention in recent years due to a rapid onset of collectivity near neutron number N=40. We report here on the first γ-ray spectroscopy beyond the (41+) state in Cr62,64, using nucleon removal reactions from several projectiles within a rare-isotope beam cocktail. A candidate for the 6+ state in Cr64 is presented as well as one for, possibly, the second excited 0+ state in Cr62. The results are discussed in comparison to the LNPS shell-model predictions that allow for neutron excitations across the N=40 harmonic oscillator gap into the g9/2 and d5/2 orbitals. The calculated level schemes for Cr62,64 reveal intriguing collective structures. From the predicted neutron particle-hole character of the low-lying states in these Cr isotopes, Cr62 emerges as a transitional system on the path to the center of the N=40 island of inversion