A Study of Tourism Advertising Effects: Advertising Formats and Destination Types

This study proposes and empirically tested the AUIDC framework for tourism advertising effects with five variables: Attention, Utilitarian, Interest, Desire, and Credibility. To examine the tourism advertising effects across different destination types and advertising formats, a 2 (destination type: cultural vs. natural) ×3 (advertising format: VR vs. video vs. print) between-subject experiment was designed and tested. A sample of 307 participants was surveyed in this study. Findings indicate that the tourism advertising effects do not differ across the three ads formats of print, video, and VR. VR is even less effective for destinations primarily featuring natural sceneries. Theoretical and managerial implications of this study are discussed

Determination of the Ignorable Boundary Condition and Standard Sample for A Novel in-situ Dynamic Mechanical Analysis Method on Soft Matter

An in-situ Dynamic Mechanical Analysis (DMA) method for soft matter developed by our group [Wu. et.al. 2022] encounters the problem of irregular samples, which significantly vary in shape and size in practice, therefore a standard sample "large enough" to ignore the boundary and size effects is necessary to determine the baseline of test and build the correspondence between this new method to classical mechanical tests. In this work, we use finite element analysis to approach the optimal size of a brick sample where the stress on the boundaries in three spatial directions are ignorable, and certified the results by testing a series of silicone gel samples on the in-situ DMA device. The stress-strain of tensile and compression are characterized. The material properties of gel are chosen to be close to the biological soft tissue. The size of 40mm(L)*40mm(W)*20mm(H) is determined to be the optimal result.Comment: 7 pages, 7 figure

A Brief Review and Perspective on the Functional Biodegradable Films for Food Packaging

High-performance, environmentally-friendly biodegradable packaging as substitutes for conventional plastics becomes severe demand to nowadays economy and society. As an aliphatic aromatic copolyester PBAT is recognized as the preferred alternative to traditional plastics. However, the relatively high cost and weak properties obstacles the widespread adoption of PBAT. Modification pertaining to improve the properties, lower the cost, and include the functional additives of PBAT is a continuous effort to meet the needs of food accessibility, antibacterial properties, oxygen resistance, high mechanical strength, stable size, low moisture absorption, and various gas permeability for commercial competitiveness

A Coarse-to-fine Framework for Automated Kidney and Kidney Tumor Segmentation from Volumetric CT Images

Automatic semantic segmentation of kidney and kidney tumor is a promising tool for the treatment of kidney cancer. Due to the wide variety in kidney and kidney tumor morphology, it is still a great challenge to complete accurate segmentation of kidney and kidney tumor. We propose a new framework based on our previous work accepted by MICCAI2019, which is a coarse-to-fine segmentation framework to realize accurate and fast segmentation of kidney and kidney tumor

tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance.

Gram-negative bacteria are intrinsically resistant to drugs because of their double-membrane envelope structure that acts as a permeability barrier and as an anchor for efflux pumps. Antibiotics are blocked and expelled from cells and cannot reach high-enough intracellular concentrations to exert a therapeutic effect. Efforts to target one membrane protein at a time have been ineffective. Here, we show that m 1 G37-tRNA methylation determines the synthesis of a multitude of membrane proteins via its control of translation at proline codons near the start of open reading frames. Decreases in m 1 G37 levels in Escherichia coli and Salmonella impair membrane structure and sensitize these bacteria to multiple classes of antibiotics, rendering them incapable of developing resistance or persistence. Codon engineering of membrane-associated genes reduces their translational dependence on m 1 G37 and confers resistance. These findings highlight the potential of tRNA methylation in codon-specific translation to control the development of multi-drug resistance in Gram-negative bacteria

Cognitive impairment in diffuse axonal injury patients with favorable outcome

Background and purposeTraumatic brain injury (TBI), especially the severe TBI are often followed by persistent cognitive sequalae, including decision-making difficulties, reduced neural processing speed and memory deficits. Diffuse axonal injury (DAI) is classified as one of the severe types of TBI. Part of DAI patients are marginalized from social life due to cognitive impairment, even if they are rated as favorable outcome. The purpose of this study was to elucidate the specific type and severity of cognitive impairment in DAI patients with favorable outcome.MethodsThe neurocognition of 46 DAI patients with favorable outcome was evaluated by the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC), and the differences in the domains of cognitive impairment caused by different grades of DAI were analyzed after data conversion of scores of nine cognitive domains of MoCA-BC by Pearson correlation analysis.ResultsAmong the 46 DAI patients with favorable outcome, eight had normal cognitive function (MoCA-BC ≥ 26), and 38 had cognitive impairment (MoCA-BC < 26). The MoCA-BC scores were positively correlated with pupillary light reflex (r = 0.361, p = 0.014), admission Glasgow Coma Scale (GCS) (r = 0.402, p = 0.006), and years of education (r = 0.581, p < 0.001). Return of consciousness (r = −0.753, p < 0.001), Marshall CT (r = −0.328, p = 0.026), age (r = −0.654, p < 0.001), and DAI grade (r = −0.403, p = 0.006) were found to be negatively correlated with the MoCA-BC scores. In patients with DAI grade 1, the actually deducted scores (Ads) of memory (r = 0.838, p < 0.001), abstraction (r = 0.843, p < 0.001), and calculation (r = 0.782, p < 0.001) were most related to the Ads of MoCA-BC. The Ads of nine cognitive domains and MoCA-BC were all proved to be correlated, among patients with DAI grade 2. However, In the DAI grade 3 patients, the highest correlation with the Ads of MoCA-BC were the Ads of memory (r = 0.904, p < 0.001), calculation (r = 0.799, p = 0.006), orientation (r = 0.801, p = 0.005), and executive function (r = 0.869, p = 0.001).ConclusionDAI patients with favorable outcome may still be plagued by cognitive impairment, and different grades of DAI cause different domains of cognitive impairment