Validation of the methylation status of <i>PTPRN2</i> in the two groups by MassARRAY EpiTYPER.

<p>(A)The overall methylation levels are displayed within amplicon A and amplicon B. (B,C) The average methylation of the CpG units of amplicon A and amplicon B are presented for late-onset severe PE and normal patients. Data are presented as means±SEM, n = 20 per group, *<i>p</i><0.05,**<i>p</i><0.01.A: Amplicon A, <i>p</i> = 0.0033;Amplicon B, <i>p</i> = 0.0017.B: Amplicon A: CpG_1, <i>p</i> = 0.0420; CpG_3, <i>p</i> = 0.4820; CpG_4, <i>p</i> = 0.1296; CpG_6, <i>p</i> = 0.2957; CpG_7, <i>p</i> = 0.6410; CpG_9, <i>p</i> = 0.0475, CpG_11, <i>p</i> = 0.0177; CpG_12.13, <i>p</i> = 0.0003. C: Amplicon B: CpG_1.2, <i>p</i> = 0.0134, CpG_3, <i>p</i> = 0.0210, CpG_4.5, <i>p</i> = 0.0185; CpG_6, <i>p</i> = 0.0163; CpG_7, <i>p</i> = 0.0019; CpG_8, <i>p</i> = 0.0001; CpG_9, <i>p</i> = 0.1268; CpG_10, <i>p</i> = 0.0192; CpG_11, <i>p</i> = 0.0583.</p

MA plot of Case-Control contrast of (A) 5mC peaks and (B) 5hmC peaks normalized with tag density.

<p>The X axis indicates the normalized mean and the Y axis indicates the log2-fold change. Red is used to indicate significantly differently expressed observations (at least 2-fold density changes and <i>p</i>-value<0.05). The blue dots show no differential expression between the two groups.</p

Gene ontology groups displaying the significant GO-terms of DMRs and DHMRs (p<0.05).

<p>(A)The significant GO-terms of DMRs between the groups. (B)The significant GO-terms of DHMRs between the groups.</p

Additional file 4: Figure S2. of Chromatin landscapes and genetic risk for juvenile idiopathic arthritis

Genes associated with these long-range interacting regions from CD4+ T cell ChIA-PET data. The genes associated with regions containing both H3K4me1 and H3K27ac marks have average higher FPKM than those genes that contained only H3K4me1 marks or those with no histone marks. (TIFF 17228 kb

Additional file 2: Figure S3. of Chromatin landscapes and genetic risk for juvenile idiopathic arthritis

Genome browser screen shots. Chromatin organization around the RUNX3 locus. (TIFF 10898 kb

Additional file 1: Table S1. of Chromatin landscapes and genetic risk in systemic lupus

is presenting genes (a) and functional pathways (b), as identified through Panther, associated with SNPs in systemic lupus. (DOCX 16 kb