1 research outputs found
Modular Synthesis of 1,2-Benzothiazines and 1,2-Benzothiazine 1‑Imines via Palladium-Catalyzed C–H/C–C Activation Reactions
In this study, a modular approach
toward cyclic sulfoximines
and
sulfondiimines via palladium-catalyzed intramolecular C–H/C-C
activation reactions was reported. Various 1,2-benzothiazines including
bicyclic, tricyclic, highly fused ones, ones of the seven-membered
ring, along with 1,2-benzothiazine 1-imines were accessed in good
yields. KIE experiment demonstrated that the C–H bond cleavage
at the position ortho to the sulfoximine group is
not the rate-determining step in the coupling reaction