Enabling research with human embryonic and fetal tissue resources

Congenital anomalies are a significant burden on human health. Understanding the developmental origins of such anomalies is key to developing potential therapies. The Human Developmental Biology Resource (HDBR), based in London and Newcastle, UK, was established to provide embryonic and fetal material for a variety of human studies ranging from single gene expression analysis to large-scale genomic/transcriptomic studies. Increasingly, HDBR material is enabling the derivation of stem cell lines and contributing towards developments in tissue engineering. Use of the HDBR and other fetal tissue resources discussed here will contribute to the long-term aims of understanding the causation and pathogenesis of congenital anomalies, and developing new methods for their treatment and prevention

Stokes-Doppler coherence imaging for ITER boundary tomography

An optical coherence imaging system is presently being designed for impurity transport studies and other applications on ITER. The wide variation in magnetic field strength and pitch angle (assumed known) across the field of view generates additional Zeeman-polarization-weighting information that can improve the reliability of tomographic reconstructions. Because background reflected light will be somewhat depolarized analysis of only the polarized fraction may be enough to provide a level of background suppression. We present the principles behind these ideas and some simulations that demonstrate how the approach might work on ITER. The views and opinions expressed herein do not necessarily reflect those of the ITER Organization

Improved ERO modelling of beryllium erosion at ITER upper first wall panel using JET-ILW and PISCES-B experience

ERO is a 3D Monte-Carlo impurity transport and plasma-surface interaction code. In 2011 it was applied for the ITER first wall (FW) life time predictions [1] (critical blanket module BM11). After that the same code was significantly improved during its application to existing fusion-relevant plasma devices: the tokamak JET equipped with an ITER-like wall and linear plasma device PISCES-B. This has allowed testing the sputtering data for beryllium (Be) and showing that the “ERO-min” fit based on the large (50%) deuterium (D) surface content is well suitable for plasma-wetted areas (D plasma). The improved procedure for calculating of the effective sputtering yields for each location along the plasma-facing surface using the recently developed semi-analytical sheath approach was validated. The re-evaluation of the effective yields for BM11 following the similar revisit of the JET data has indicated significant increase of erosion and motivated the current re-visit of ERO simulations.EURATOM 63305

Thermographic study of heat load asymmetries during MAST L-mode discharges

Abstract. A long wavelength range infrared camera (LWIR) has been installed on MAST to compliment the existing medium wave infrared system. Simultaneous LWIR/MWIR temperature measurements have been made in the lower and upper divertors of MAST. As expected, the LWIR system is less sensitive to disturbances from hot spots on the surface. A thorough correction of the surface effects using both systems has improved the reliability of the heat flux calculations in MAST. A careful assessment of the heat load asymmetries as a function of the magnetic geometry has been carried out during a variety of L-mode discharges (single and double null, reversed and forward field). In all cases, most of the energy arriving in the SOL goes to the outer divertor. The in/out power ratio is found to be different for lower and upper single null discharges with more power going to the outer divertor in the latter case. In addition, it is found that the heat flux profile width is different in the upper and lower divertor. The heat flux profile width at the secondary strike point increases with increasing δr sep