First-year university retention and academic performance of non-traditional students entering via an Australian pre-university enabling program

Introduction: Pre-tertiary enabling programs have become an increasingly popular pathway to university in Australia in recent years, however little is published about how well enabling students fare once they start university. This paper examines and compares first-year retention and academic outcomes of students that entered Murdoch University between 2014 and 2016 via successful completion of its enabling program, OnTrack. A greater proportion of students transitioning via OnTrack were from equity and disadvantaged backgrounds than any other entry pathway; thereby demonstrating an important function of this enabling program in boosting the representation of these students at the university. Further, OnTrack-pathway students were retained at a rate that was similar or better than students entering via all other admission pathways, despite poorer academic performance. This persistence suggests enhanced resilience amongst this cohort, potentially built during their enabling education experience. Multivariate regression modelling was also undertaken, revealing that admission pathway, demographic and enrolment factors collectively explainedvery little of the observed variation in student outcomes for all first year students, and were particularly poor predictors of academic underperformance. Thus, once students are enrolled in undergraduate study, student outcomes may be better explained by student variables not captured in university databases, such as personal circumstances or psychological factors. In summary, these findings provide empirical data to support the notion that enabling programs have been successful in ‘enabling’ access and participation of students who are capable but otherwise lack opportunity, including those from disadvantaged backgrounds. However, enabling pathway students may experience ongoing challenges that impact their academic performance, and thus future equity and access policy should address appropriate mechanisms for supporting the broader transition experience of these students

Neonatal immune function and inflammatory illnesses in later life: Lessons to be learnt from the developing world?

With the emergence of allergic and autoimmune diseases in populations that have started to transit to a western lifestyle, there has been an increasing interest in the role of environmental factors modulating early immune function. Yet, most of the information concerning neonatal immune function has been derived from studies in westernized countries. We postulate that comparative studies of early immune development in children born under conditions that are typical for a westernized vs. that of a still more traditional setting will provide a crucial insight into the environmental-driven immunological mechanisms that are responsible for the world-wide rise in inflammatory disorders. In this review, we summarize the current understanding of early-life immune function in humans in general and the literature on some major lifestyle factors that may influence neonatal immune function and potentially the risk for disease in later life. An understanding of the mechanisms of ‘prenatal/early-life programming’ in populations living in traditional compared with modern societies is crucial to develop strategies to prevent a further rise in ‘western diseases’ such as allergic disorders. Indications exist that prenatal conditioning of the innate immune system by low-grade inflammatory responses is key to inducing more tightly regulated postnatal adaptive immune responses

Enabling learners starts with knowing them: Student attitudes, aspiration and anxiety towards science and maths learning in an Australian pre-university enabling program

Pre-university enabling programs provide an important pathway to university for underprepared and disadvantaged students. In order to adequately prepare students for their university journey, enabling educators need to understand and respond to the evolving needs of their learners; not only their academic disparity, but also their past learning experiences and perceptions towards particular subjects. In the current study, students entering an Australian enabling program, ‘OnTrack’, were surveyed on their attitudes, emotions and aspirations towards the study of science and mathematics. Responses were associated with student perceptions of their past science and maths learning experiences. There was incongruity between student expectations of what future study would entail and the realities of their degree choices and career aspirations. This study suggests the need for social and emotional learning and teacher training. Greater attention should be given to both student’s affective needs and their understanding of future course content during their enabling education experience to redress negative emotional learning experiences and safeguard student expectations, satisfaction, and retention in the future

Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns

Background:  Environmental changes, including declining microbial exposure, have been linked with the rising incidence of allergic and autoimmune diseases in ‘western’ populations. This potentially occurs by altering early development of immuno-regulatory pathways including T regulatory cells (Treg). There is now increasing evidence that such conditioning begins in utero. Methods:  We compared neonatal Treg from children born under typical western conditions (Australia, AUS) with those of neonates born under more traditional conditions of high microbial burden (Papua New Guinea, PNG). Results:  The frequency of neonatal Treg, defined as CD4+ Foxp3+ CD127− CD25+/high was found to be higher in the cord blood of AUS compared to PNG newborns. However, cord Tregsuppressive function in a small subset of children was qualitatively similar between PNG and AUS newborns in both a Treg depletion assay and a Treg supplementation assay. Conclusions:  These findings do not support the hypothesis that living in a ‘western’ versus more traditional environment leads to poor induction or suppressive function of neonatal Treg. However, environmentally-induced immuno-regulation may potentially occur via alternative mechanisms in PNG newborns that should now be investigated further

Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions

Background One explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern environmental conditions. There is increasing evidence that the process of immune deviation already begins in utero, but the underlying immunologic mechanisms are not clear. Objective We sought to identify differences in the function of neonatal antigen-presenting cells (APCs) in children born in settings that are more traditional versus those of modern societies. Methods Cord blood mononuclear cells were collected from newborns from Papua New Guinea (PNG; traditional) and Australia (modern) and compared for differences in APCs and T-cell phenotype and function. Results Australian cord naive T cells (CD4+CD25−CD127+ cells) showed an enhanced and more rapid proliferative response in an autologous, APC-dependent culture system, a result of differences in neonatal APCs rather than T-cell function. This included an increased capacity to process antigen and to upregulate activation markers after stimulation. In contrast, resting PNG APCs exhibited higher baseline levels of activation and inhibitory markers and were less responsive or nonresponsive to stimulation in vitro. Conclusions This study supports the hypothesis that prenatal environments can influence the developing immune system in utero. Children born under modern environmental conditions exhibit increased APC reactivity at birth compared with children born under traditional environmental conditions. The functionally more quiescent nature of PNG neonatal APCs might protect against the development of harmful inflammatory responses in early life