Models.

<p>The four models describe four different scenarios for how a patient, who at the time of resection has no detectable or growing cancers, progresses between the states of dormancy, clearance, growth, and relapse.</p

Fitting models to relapse data.

<p>The Zeroth Model and Models 1–3 fitted to relapse data from two long-term follow-up studies: patients are grouped by age in the study EBCTCG (Panel A), whereas patients are grouped by ER status in the study Chia et al. (Panel B). Black dots are data points; solids curves are the models for the fitted parameters (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062320#pone-0062320-t002" target="_blank">Table 2</a>). Hazard rates are inset.</p

Models fitted to relapse data.

<p>Parameters fitted to EBCTCG relapse data and Chia et al. relapse data for the Zeroth Model and for Models 1–3. The growth time is fixed at 3 years for EBCTCG data and at years for Chia et al. data.</p

Estimates of means (top row) and standard deviations (bottom row) in patients' numbers of micrometastases.

<p>This is up to 20 years post-resection for different values of : (black), (red), (orange), (green). The graphs use extrapolated hazard rates from Models 0–3 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062320#pone-0062320-g002" target="_blank">Figure 2</a>) for the EBCTCG data set (panel A) and the Chia et al. data set (panel B). In each plot, graphs that have solid/dot-dashed/long-dash/short-dash lines correspond to Zeroth Model/Model 1/Model 2/Model 3.</p

Peaks in the relapse rate.

<p>RFI curves (top) and corresponding relapse rates (bottom) for Models 1–3 as parameters (Model 1)/ (Model 2)/ (Model 3) are reduced. In each plot, // decreases such that the ratio of the right-hand side to the left-hand side of the corresponding inequality determining whether there is a peak in the relapse rate is 2 (long-dashed line), 1 (short-dashed line), 1/5 (dotted line) and 1/25 (solid line).</p

Additional file 9: Figure S6. of Long-term microfluidic tracking of coccoid cyanobacterial cells reveals robust control of division timing

Growth behavior is similar across all chambers in light-dark cycle experiment. (a) Total growth in different chambers under light-dark cycles. Substantial growth is observed during illuminated periods across all microfluidic chambers. In the dark, minimal growth is detected. (b) Residual errors (gray, with mean shown in black) of exponential fits to lineage growth curves during the illumination periods L1 and L2 of Fig. 3a. (PDF 366 kb

Additional file 1 of Longevity of dental restorations in Sjogren’s disease patients using electronic dental and health record data

Supplementary Material