Anti-food and anti-microbial serum IgG and IgA levels in CD patients with or without stricturing/penetrating disease and controls.

<p>Specific serum IgG (A) and IgA (B) were quantified by ELISA in control patients/healthy controls (n = 61) and CD patients without (n = 17) and with (n = 34) stricturing and/or penetrating complications. Boxes indicate median and 25/75 percentiles and whiskers indicate 10/90 percentiles. P values were determined by Kruskal-Wallis test followed by a Dunn's post hoc test (*<0.05; **<0.01; ***<0.001) or by Mann Whitney U test (# <0.05). Mann Whitney U test was only applied between CD subgroups and results are only shown if the Dunn's post hoc test did not show any significance.</p

Anti-food and anti-microbial serum IgG and IgA levels in CD patients with or without arthropathy and controls.

<p>Specific serum IgG (A) and IgA (B) were quantified by ELISA in control patients/healthy controls (n = 61) and CD patients without (n = 39) and with (n = 12) current arthropathy. Boxes indicate median and 25/75 percentiles and whiskers indicate 10/90 percentiles. P values were determined by Kruskal-Wallis test followed by a Dunn's post hoc test (*<0.05; **<0.01; ***<0.001).</p

Serum IgG and IgA levels specific for food and microbial antigens in IBD patients and controls.

<p>Serum IgG (A–F) and IgA (G–L) specific for ovalbumin (A/G), wheat (B/H), milk (C/I), mannan from <i>S. cerevisiae</i>  =  ASCA (D/J), and lysates from <i>E. coli</i> K12 (E/K) and <i>B. fragilis</i> ATCC 25285 (F/L) were quantified by ELISA in control patients/healthy controls (Con; n = 61) and patients suffering from CD (n = 52), UC (n = 29) and acute gastroenteritis/colitis (AGE; n = 12). Each dot represents one patient. Medians with interquartile ranges are indicated. P values (*<0.05; **<0.01; ***<0.001) were determined by Kruskal-Wallis test followed by a Dunn's post hoc test.</p

Summary of results. Ab levels compared to controls.

1<p>Slightly increased anti-food IgA levels in CD patients with a structuring/penetrating phenotype.</p>2<p>Decreased anti-food IgG levels in CD and UC patients with artopathy.</p>3<p>Only some microbial antigens.</p>4<p>Patients receiving anti-TNFα treatment have lower Ab levels.</p><p>Summary of results. Ab levels compared to controls.</p

Anti-food and anti-microbial serum IgG and IgA levels in CD patients with or without anti-TNFα treatment and controls.

<p>Specific serum IgG (A) and IgA (B) were quantified by ELISA in control patients/healthy controls (n = 61) as well as in CD patients without (n = 17) and with (n = 34) current anti-TNFα treatment. Boxes indicate median and 25/75 percentiles and whiskers indicate 10/90 percentiles. P values were determined by Kruskal-Wallis test followed by a Dunn's post hoc test (*<0.05; **<0.01; ***<0.001) or by Mann Whitney U test (# <0.05). Mann Whitney U test was only applied between CD subgroups and results are only shown if the Dunn's post hoc test did not show any significance.</p