Effect of butylphthalide in patients with vascular cognitive impairment

Purpose: To study the effects of butylphthalide in patients with vascular cognitive impairment. Method: Sixty patients with vascular cognitive impairment were randomly divided into control group and butylphthalide (NBP) group (n = 30). Control group received blood pressure control, blood sugar control, and lipid-lowering therapies, while NBP group received butylphthalide capsules (200 mg, thrice daily). Treatments in both groups lasted for 14 days. Thereafter, Hasegawa Dementia Scale (HDS), Mini-Mental State Examination (MMSE), Activities of Daily Living Scale (ADL), and event-related potential (P300) were used to evaluate the effects of butylphthalide treatment. Result: Following 14 days of treatment, HDS, MMSE and ADL scores of NBP group were significantly higher than those of the control group (p < 0.05). The P300 latency of NBP group was shorter than that of control group, while P300 amplitude was higher than that of control group (p < 0.05). Conclusion: Butylphthalide treatment achieves higher scores of HDS, MMSE and ADL scores, but shorter P300 latency. These results provided good evidence of the effectiveness of butylphthalide therapy in the management of vascular cognitive impairment. However, further clinical trials are recommended prior to application in clinical practice

Combining hydrogen peroxide addition with sunlight regulation to control algal blooms

The concentration, light conditions during treatment, and the number of hydrogen peroxide (H2O2) additions as well as the H2O2 treatment combined with subsequent shading to control algal blooms were studied in the field (Lake Dianchi, China). The cyanobacterial stress and injury due to H2O2 were dose dependent, and the control effectiveness and degradation of H2O2 were better and faster under full light than under shading. However, H2O2 was only able to control a bloom for a short time, so it may have promoted the recovery of algae and allowed the biomass to rebound due to the growth of eukaryotic algae. A second addition of H2O2 at the same dose had no obvious effect on algal control in the short term, suggesting that a higher concentration or a delayed addition should be considered, but these alternative strategies are not recommended so that the integrity of the aquatic ecosystem is maintained and algal growth is not promoted. Moreover, shading (85%) after H2O2 addition significantly reduced the algal biomass during the enclosure test, no restoration was observed for nearly a month, and the proportion of eukaryotic algae declined. It can be inferred that algal blooms can be controlled by applying a high degree of shading after treatment with H2O2.</p

Favoring Eagerness for Remaining Items: Designing Efficient, Fair, and Strategyproof Mechanisms

In the assignment problem, the goal is to assign indivisible items to agents who have ordinal preferences, efficiently and fairly, in a strategyproof manner. In practice, first-choice maximality, i.e., assigning a maximal number of agents their top items, is often identified as an important efficiency criterion and measure of agents' satisfaction. In this paper, we propose a natural and intuitive efficiency property, favoring-eagerness-for-remaining-items (FERI), which requires that each item is allocated to an agent who ranks it highest among remaining items, thereby implying first-choice maximality. Using FERI as a heuristic, we design mechanisms that satisfy ex-post or ex-ante variants of FERI together with combinations of other desirable properties of efficiency (Pareto-efficiency), fairness (strong equal treatment of equals and sd-weak-envy-freeness), and strategyproofness (sd-weak-strategyproofness). We also explore the limits of FERI mechanisms in providing stronger efficiency, fairness, or strategyproofness guarantees through impossibility results