Death of three Loop Current rings

The life cycle of large anticyclonic rings in the Gulf of Mexico (GOM) is widely described by pinch off from the Loop Current, migration across the Gulf and eventual spin down along the western slope. Extensive observational and modeling efforts provide a relatively consistent picture of rings pinching off from the Loop Current and of complex interaction between anticyclones and cyclones driven by bathymetry along the western and northwestern shelf. The observational record for Loop Current rings (LCRs) during the intermediate period of westward translation is less clear. A number of studies recognize distinct anomalies in LCR characteristics in deep water as the rings enter the western Gulf near 92-94W. These include abrupt changes in the geometry of observed drifter trajectories and derived eddy parameter fits as well as changes in both ring translation speeds and the estimated rate of ring decay. Such observations are consistent with intense interaction and mass exchange between the rings and other coherent mesoscale features known to be present in the western Gulf. We test the hypothesis that interactions with the ambient mesoscale field can lead to rapid loss of coherence of some LCRs well before they reach the \u27eddy graveyard\u27 in the western Gulf. We use the data-assimilating, eddy-resolving numerical GOM model described by Kantha et al. (2005) to assess the fates of readily identified LCRs Fourchon, Juggernaut, and Millenium during the period July 1998 to August 2001. Lagrangian metrics, including relative dispersion of small drifter clusters seeded in the ring cores, analysis of evolving blobs seeded in the ring cores, and finite-scale Lyapunov exponents, are used to track model ring evolution. These metrics clearly show that interactions with existing mesoscale cyclones and anticyclones caused Fourchon and Juggernaut to break up near 92W on advective time scales. In addition, Millenium also experienced an intense deformation, stirring, and mixing episode near 92W. Blob studies showed that the core fluid of Millenium was ultimately dispersed over much of the western basin. Our results show that some LCRs may break up through interactions with existing western Gulf cyclones and anticyclones prior to reaching the western slope

Blending HF Radar and Model Velocities in Monterey Bay Through Normal Mode Analysis

Nowcasts of the surface velocity field in Monterey Bay are made for the period August 1-9, 1994, using HF radar observations blended with results from a primitive equation model. A spectral method called normal mode analysis was used. Objective spatial and temporal filtering were performed, and stream function, velocity potential, relative vorticity, and horizontal divergence were calculated over the domain. This type of nowcasting permits global spectral analysis of mode amplitudes, calculation of enstrophy, and additional analyses using tools like empirical orthogonal functions. The nowcasts reported here include open boundary flow information from the numerical model. Nowcasts using no open boundary flow information, however, still provide excellent results for locations within the observation footprint. This method, then, is useful for filtering high-resolution data like HF radar observations, even when open boundary flow information is unavailable. Also, since the nowcast velocity gradient fields were much less noisy than the observations, this may be an effective method for preconditioning high-resolution observation sets for assimilation into a numerical model. Copyright 2000 by the American Geophysical Union

Synoptic Lagrangian maps: Application to surface transport in Monterey Bay

Here we report on an effort to describe in detail the evolution of surface water particles in Monterey Bay from the time they first enter until the time they leave. The data used for this study are objective mappings from hourly surface currents obtained from high frequency (HF) radar measurements in Monterey Bay for the period 2 June through 4 August 1999. The basic concept is simple: compute the origin and fate of a large number of particles for every hour during the analysis period. However, analyzing and displaying the enormous amount of computed trajectory information required a new data compression technique: synoptic Lagrangian maps produced by representing each trajectory by its origin/fate and its residence time. The results show unexpected complexity and variability not apparent in the Eulerian current archive. For example, the fraction of particles that escaped to the open ocean during this period varied from about 17 to more than 92 percent. Mean particle residence times ranged from 4.5 to 11 days. The distribution of particle residence times and transport pathways varied over time scales from hours to weeks, and space scales from 2 to 40 km. The wide range of variability in particle properties reported here shows that surface transport studies in Monterey Bay require detailed wind and tidal current information over the entire bay, as well as information about the flow along the open ocean boundary

Integrable unsteady motion with an application to ocean eddies

Application of the Brown-Samelson theorem, which shows that particle motion is integrable in a class of vorticity-conserving, two-dimensional incompressible flows, is extended here to a class of explicit time dependent dynamically balanced flows in multilayered systems. Particle motion for nonsteady two-dimensional flows with discontinuities in the vorticity or potential vorticity fields (modon solutions) is shown to be integrable. An example of a two-layer modon solution constrained by observations of a Gulf Stream ring system is discussed

Fibrosis: Sirtuins at the checkpoints of myofibroblast differentiation and profibrotic activity

Fibrotic diseases are still a serious concern for public health, due to their high prevalence, complex etiology and lack of successful treatments. Fibrosis consists of excessive accumulation of extracellular matrix components. As a result, the structure and function of tissues are impaired, thus potentially leading to organ failure and death in several chronic diseases. Myofibroblasts represent the principal cellular mediators of fibrosis, due to their extracellular matrix producing activity, and originate from different types of precursor cells, such as mesenchymal cells, epithelial cells and fibroblasts. Profibrotic activation of myofibroblasts can be triggered by a variety of mechanisms, including the transforming growth factor-β signalling pathway, which is a major factor driving fibrosis. Interestingly, preclinical and clinical studies showed that fibrotic degeneration can stop and even reverse by using specific antifibrotic treatments. Increasing scientific evidence is being accumulated about the role of sirtuins in modulating the molecular pathways responsible for the onset and development of fibrotic diseases. Sirtuins are NAD+-dependent protein deacetylases that play a crucial role in several molecular pathways within the cells, many of which at the crossroad between health and disease. In this context, we will report the current knowledge supporting the role of sirtuins in the balance between healthy and diseased myofibroblast activity. In particular, we will address the signalling pathways and the molecular targets that trigger the differentiation and profibrotic activation of myofibroblasts and can be modulated by sirtuins.</p