Cooperative Development of L75 LOX Ethanol engine: Current Status with Focus on Capacitive Chamber Testing

In 2011 DLR and AEB agreed to cooperate in the field of liquid propulsion. The L75 engine project, which started in 2008 in Brazil, is the focus of this effort. The most important event in the project up to this date is the test campaign of the capacitive thrust chamber, a full-scale model of the L75 injection head and combustion chamber, which is the main focus of this paper, along with the status of other advances made in the project during the last year

SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark:a nationwide cross-sectional study

BACKGROUND: People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with “Severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). The aim of this study was to determine the prevalence of SARS-CoV-2 among PEH and shelter workers in Denmark. DESIGN AND METHODS: In November 2020, we conducted a nationwide cross-sectional seroprevalence study among PEH and shelter workers at 21 recruitment sites in Denmark. The assessment included a point-of-care test for antibodies against SARS-CoV-2, followed by a questionnaire. The seroprevalence was compared to that of geographically matched blood donors considered as a proxy for the background population, tested using a total Ig ELISA assay. RESULTS: We included 827 participants in the study, of whom 819 provided their SARS-CoV-2 antibody results. Of those, 628 were PEH (median age 50.8 (IQR 40.9–59.1) years, 35.5% female) and 191 were shelter workers (median age 46.6 (IQR 36.1–55.0) years and 74.5% female). The overall seroprevalence was 6.7% and was similar among PEH and shelter workers (6.8% vs 6.3%, p = 0.87); and 12.2% among all participants who engaged in sex work. The overall participant seroprevalence was significantly higher than that of the background population (2.9%, p < 0.001). When combining all participants who reported sex work or were recruited at designated safe havens, we found a significantly increased risk of seropositivity compared to other participants (OR 2.23, 95%CI 1.06–4.43, p = 0.02). Seropositive and seronegative participants reported a similar presence of at least one SARS-CoV-2 associated symptom (49% and 54%, respectively). INTERPRETATIONS: The prevalence of SARS-CoV-2 antibodies was more than twice as high among PEH and associated shelter workers, compared to the background population. These results could be taken into consideration when deciding in which phase PEH are eligible for a vaccine, as part of the Danish national SARS-CoV-2 vaccination program rollout. FUNDING: TrygFonden and HelseFonden. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-022-13642-7

The effects of tibolone in older postmenopausal women

Robert Norman and Alastair MacLennan were investigators in the LIFT TrialSteven R. Cummings, Bruce Ettinger, Pierre D. Delmas, Peter Kenemans, Victoria Stathopoulos, Pierre Verweij, Mirjam Mol-Arts, Lenus Kloosterboer, Lori Mosca, Claus Christiansen, John Bilezikian, Eduardo Mario Kerzberg, Susan Johnson, Jose Zanchetta, Diederich E. Grobbee, Wilfried Seifert and Richard Eastell for the LIFT Trial Investigator

Biology of moderately halophilic aerobic bacteria

The moderately halophilic heterotrophic aerobic bacteria form a diverse group of microorganisms. The property of halophilism is widespread within the bacterial domain. Bacterial halophiles are abundant in environments such as salt lakes, saline soils, and salted food products. Most species keep their intracellular ionic concentrations at low levels while synthesizing or accumulating organic solutes to provide osmotic equilibrium of the cytoplasm with the surrounding medium. Complex mechanisms of adjustment of the intracellular environments and the properties of the cytoplasmic membrane enable rapid adaptation to changes in the salt concentration of the environment. Approaches to the study of genetic processes have recently been developed for several moderate halophiles, opening the way toward an understanding of haloadaptation at the molecular level. The new information obtained is also expected to contribute to the development of novel biotechnological uses for these organisms

EuReCa ONE—27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

AbstractIntroductionThe aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.MethodsThis was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.ResultsData on 10,682 confirmed OHCAs from 248 regions in 27 countries, covering an estimated population of 174 million. In 7146 (66%) cases, CPR was started by a bystander or by the EMS. The incidence of CPR attempts ranged from 19.0 to 104.0 per 100,000 population per year. 1735 had ROSC on arrival at hospital (25.2%), Overall, 662/6414 (10.3%) in all cases with CPR attempted survived for at least 30 days or to hospital discharge.ConclusionThe results of EuReCa ONE highlight that OHCA is still a major public health problem accounting for a substantial number of deaths in Europe.EuReCa ONE very clearly demonstrates marked differences in the processes for data collection and reported outcomes following OHCA all over Europe. Using these data and analyses, different countries, regions, systems, and concepts can benchmark themselves and may learn from each other to further improve survival following one of our major health care events

2nd European space generation workshop: Market introduction strategy for a new European heavy lift launch vehicle

The Space Generation Advisory Council (SGAC) is a non-profit organisation and professional network that represents university students and young professionals in the space sector. SGAC has permanent observer status in the United Nations Committee on Peaceful Uses of Outer Space (COPUOS) and is a member of the UN Economic and Social Council, and International Astronautical Federation (IAF). Headquartered in Vienna with full-time staff, the organisation is supported by a volunteer network of over 4,000 members in more than 90 countries. The 2nd European Space Generation Workshop (2nd E-SGW) took place in Paris, on 24 and 25 March 2017. The main goals of the 2nd E-SGW are to strengthen the regional network of students and young professionals in the European region, to examine and consider key questions that the European space community is facing from an interdisciplinary point of view, and to provide the opportunity for the next generation of space professionals to interact with today's space leaders. In dedicated working groups, delegates tackled topics of Space Economy, Space Accessibility, Space Diplomacy, Space Exploration. This paper presents potential strategies for the market introduction of a future European heavy-lift launch vehicle, based on the main findings and recommendations of the Space Accessibility Working Group. On the example of Ariane 6, which is scheduled for a maiden flight in 2020, crucial factors, such as launch cost, performance, time to market, launch rate, competition and satellite market situation as well as vehicle reliability and launch record are discussed, and their impact on potential market introduction strategies evaluated. Considering the economic and technological aspects of the introduction of a new launcher, the industrial organisation is examined, and the influence of national and European space policy and potential areas for support by lawmakers are identified. Furthermore, elements for marketing and outreach activities with respect to various target groups are presented.SCOPUS: cp.pinfo:eu-repo/semantics/publishe