Non-protein coding RNAs: making their own path losing translation

Ribonucleic acid (RNA) can serve genetic, catalytic, structural, and regulatory roles. Non-coding RNA (ncRNA) genes make transcripts that function directly as RNA, rather than encoding proteins. Transfer RNA and ribosomal RNA are well known examples of non-coding RNA. Around 98% of all transcriptional output in humans is non-coding RNA. RNA-mediated gene regulation is widespread in higher eukaryotes and complex genetic phenomena like RNA interference, co-suppression, transgene silencing, imprinting, methylation, and possibly position-effect variegation and transvection, all involve intersecting pathways based on or connected to RNA signaling. Due to its high abundance, non-coding RNAs have several important biological roles in living organisms

Application of Molecular Tools for Gut Health of Pet Animals: A Review

Gut health is an important facet of well being of pet animals; it is in this context, various nutritional and biotechnological approaches have been proposed to manipulate the gut health by specifically targeting the colonic microbiota. Nutritional approaches include supplementation of antioxidants and phytochemicals like flavonoids, isoflavonoids and carotenoids. Biotechnological approaches include supplementation of probiotics, prebiotics, synbiotics in the diet and potential application of molecular tools like fluorescent in situ hybridization, denaturing gradient gel electrophoresis, quantitative dot blot hybridization, and restriction fragment length polymorphism etc. in studying the fecal microbiota composition. Post-genomic and related technologies, i.e. genomics, nutrigenomics, transcriptomics, proteomics, metabolomics and epigenomics in the study of gastrointestinal tract also put forward challenges for nutritionists and microbiologists to elucidate the complex interactions between gut microbiota and host

Nutritional Interventions to Reduce Methane Emissions in Ruminants

Methane is the single largest source of anthropogenic greenhouse gases produced in ruminants. As global warming is a main concern, the interest in mitigation strategies for ruminant derived methane has strongly increased over the last years. Methane is a natural by-product of anaerobic microbial (bacteria, archaea, protozoa, and fungi) fermentation of carbohydrates and, to a lesser extent, amino acids in the rumen. This gaseous compound is the most prominent hydrogen sink product synthesized in the rumen. It is formed by the archaea, the so-called methanogens, which utilize excessive ruminal hydrogen. Different nutritional strategies to reduce methane production in ruminants have been investigated such as dietary manipulations, plant extracts, lipids and lipid by-products, plant secondary metabolites, flavonoids, phenolic acid, statins, prebiotics, probiotics, etc. With the range of technical options suggested above, it is possible to develop best nutritional strategies to reduce the ill effects of livestock on global warming. These nutritional strategies seem to be the most developed means in mitigating methane from enteric fermentation in ruminants and some are ready to be applied in the field at the moment

Application of Molecular Tools for Gut Health of Pet Animals: A Review

Gut health is an important facet of well being of pet animals; it is in this context, various nutritional and biotechnological approaches have been proposed to manipulate the gut health by specifically targeting the colonic microbiota. Nutritional approaches include supplementation of antioxidants and phytochemicals like flavonoids, isoflavonoids and carotenoids. Biotechnological approaches include supplementation of probiotics, prebiotics, synbiotics in the diet and potential application of molecular tools like fluorescent in situ hybridization, denaturing gradient gel electrophoresis, quantitative dot blot hybridization, and restriction fragment length polymorphism etc. in studying the fecal microbiota composition. Post-genomic and related technologies, i.e. genomics, nutrigenomics, transcriptomics, proteomics, metabolomics and epigenomics in the study of gastrointestinal tract also put forward challenges for nutritionists and microbiologists to elucidate the complex interactions between gut microbiota and host

Nutritional stretegies to prevent Urolithiasis in Animals

Urolithiasis is a common problem in both ruminants and non-ruminants and nutrition plays a significant role in predisposing urolithiasis. The nutritional factors mainly influence urinary constituents and pH, which affect stone nucleation and growth. While surgery can render a patient stone-free, non-operative treatment modalities are required to prevent and reduce the risk of recurrent urolithiasis. Moreover, long-term pharmacological therapy and its potential side effects often lead to subsequent failure. In this regard, nutritional management is the best preventive strategy against urolithiasis. [Vet. World 2011; 4(3.000): 142-144

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Not AvailableHeat stress remains the most important stressor, especially across the tropical regions of the world. In the current study, effects of ascorbic acid were investigated for its impact on summer-induced heat-stress in ducks. A total of 60 twelve weeks old White Pekin ducks were randomly distributed into 3 experimental groups with replicates having 10 birds in each group. The ducks under the therapeutic trial groups were supplemented with vitamin C of 250mg or 500 mg per kg of feed along with a basal diet. This experimental feeding, ad libitum, continued for 7 weeks period. The maximum and minimum temperature along with relative humidity in the pen was recorded on daily basis, throughout the experiment. Blood samples were collected and analyzed for haemato-biochemical and oxidative stress parameters. Vitamin C treatment improved the haemato-biochemical and oxidative parameters alteration caused by summer-induced heat stress in ducks. Therefore, dietary supplementation by vitamin C have significant role in mitigating the summer-induced heat-stress.Not Availabl