Development and Implications of Controlling in the Public Sector

Controlling is essential for public organizations to deliver optimal performance. However, the existing literature lacks sufficient knowledge to help organizations implement better strategies to enhance control. Therefore, this study examined the concept of control in the public sector, its impact on organizational efficiency, and a key focus on implementation. This study adopted a mixed approach (qualitative and quantitative) to study control in the public sector. The literature review was used to gather qualitative data, and a survey was conducted among the managers working in Russian public organizations to determine their responses to controlling practices. The results were compared and analyzed to provide implications and recommendations. It was noted through the results that control in public organizations depends on various factors like controlling approaches and tools, organizational culture, the autonomy of management, and functional control of organizations. Each of these aspects contributes positively toward control and improves public organizations’ efficiency. Therefore, these aspects should be the core focus of public organizations to ensure greater control and efficiency. This research targeted this area to bridge the gap and determine the concept of controlling the Russian public sector. However, this research also has a limitation in that it has surveyed only 102 managers from different Russian public organizations. Doi: 10.28991/ESJ-2023-07-01-015 Full Text: PD

Self-force of a point charge in the space-time of a massive wormhole

We consider the self-potential and the self-force for an electrically charged particle at rest in the massive wormhole space-time. We develop general approach for the renormalization of electromagnetic field of such particle in the static space-times and apply it to the space-time of the wormhole with parameter of the mass, $m$. The self-force is found in manifest form; it is an attractive force. We discus the peculiarities due to massive parameter of the wormhole.Comment: 10 pages, 1 figure text correcte

Assessment of diet, bad habits and psychological status in men and women of the XXI century

Background. The modern rhythm of life has a negative impact on the people lifestyle. Daily stress factors, anxiety, sleep disturbance contribute to the spread of bad habits and excessive consumption of sugars, which, in combination with physical inactivity, leads to weight gain and obesity, and subsequently the development of a number of associated diseases. Methods. Using a specially designed questionnaire, including questions about nutrition, bad habits, physical activity, psychological status, a direct, voluntary survey of 120 socially active, able-bodied men and women was conducted. The risk of developing diabetes mellitus was assessed using the FINDRISK scale, height, body weight, waist circumference were also measured, and body mass index was calculated. Results. The vast majority of respondents (72.5%) noted one or another lack in their lifestyle. More than half of females and males (only 57.5 % of participants) lead a sedentary lifestyle. An increased intake of sugars was revealed in the diet, 18.33 % of the participants consumed fast food weekly, among men there was insufficient consumption of fresh vegetables and fruits. Analysis of bad habits showed that 15.83 % of respondents smoke, 15 % (most men) use energy drinks, 5 % of respondents abuse alcohol. Sleep disorders are widespread in both sexes (generally 55 %), anxiety, mainly among women (51.76 %), depressive background was most often recorded among consumers of energy drinks (66.67 %). Insufficient awareness of rational nutrition was noted in both sexes. When setting goals for lifestyle correction, multitasking was revealed (more than three tasks in 20 % of men and 21.18 % of women) and a high expectation of achieving results. Conclusions. The results of the study highlight numerous risk factors in the lifestyle of socially active people of both sexes which if not corrected in time, can lead to the development of a number of serious diseases

Differences in expression profiles in malingant melanoma patients according to immunotherapy response

One of the most important branch of modern molecular genetics and biomedicine is the search for predictive markers that help choose the most effective way of treatment, drug and also determine its individual dosage. Among the markers, those that can provide the possibility of using a non­invasive, so­called “liquid biopsy” are considered particularly promising. This method allows the condition of the tumor to be assessed by analyzing the body’s natural fluids, such as blood, urine or saliva. Such studies are most convenient in those cases when it is necessary to monitor the effectiveness of therapy in order to record the time of the onset of resistance of tumor cells, the onset of relapse and to move on to the next line of therapy. In the treatment of aggressive and rapidly became metastatic malignant tumors, such as melanoma, the presence of reliable markers that allow quick and accurate determination of treatment tactics is especially important. Nowadays, there is an increasing number of studies devoted to the search for predictive markers of the effectiveness of immunotherapy. Melanoma is one of the most immunogenic tumors and, as a result, has become a model object for research into and introduction of new approaches to immunotherapy. In this study, we compared two groups of patients with metastatic skin melanoma, with different responses to immunotherapy with blockers of immune control points, to identify new predictive expression biomarkers among microRNAs and mRNAs, and to identify the genes responsible for the occurrence of an objective response to therapy. As a result, the study detected several microRNAs with a significant change in expression level within the tumor tissue of patients responding differently to immunotherapy. Differences in the level of expression of their target genes have also been found, that will allow a more detailed analysis of the molecular mechanisms that determine the sensitivity or resistance of malignant melanoma cells to the immunotherapy. Based on the obtained data, we have proposed expression markers (mRNAs and microRNAs) that can be used as predictors of malignant melanoma tumors to immunotherapy

Knockdown of hexokinase 2 results in a decreased expression level of the glycolytic enzymes PFKP, BPGM, and GPI in RKO cell line

Colorectal cancer (CRC) is one of the most common malignant neoplasms in the world, and is characterized by a high mortality rate. The study of the key aspects of colorectal cancer formation and progression is necessary to develop new approaches to its therapy, as well as to search for new diagnostic, prognostic and predictive biomarkers of CRC. In many types of tumors, one of the key changes in metabolism is the  activation of glycolysis, which is associated with alterations in the expression of the main glycolytic enzymes and regulatory molecules. There is often an increase in hexokinase 2 (HK2) exogenous expression in tumor cells, which makes it a promising target for anticancer therapy. Quantitative expression analysis of 15 genes (GAPDH, ADPGK, ALDOA, ENO3, PFKL, PGK1, PGAM1, PKM2, ENO1, PDK1, PDK3, PFKP, ENO2, GPI, and BPGM), encoding the key glycolysis enzymes, as well as HIF1A gene was carried out in a modified RKO cell line, which constantly expresses the short hairpin RNA (shRNA) for the inhibition of hexokinase 2. A significant decrease in the expression of PFKP, BPGM, and GPI genes both at the mRNA (5­, 86­, and 93­fold, respectively) and protein (2.5­, 3.5­, and 19­fold, respectively) levels was revealed. Probably, the downregulation of GPI and PFKP is associated with a decrease in the amount of their substrates, glucose­6­phosphate and fructose6­phosphate, under the inhibition of hexokinase 2. Nevertheless, the cause of a decreased mRNA level of these three enzymes, while the expression level of other glycolytic participants is constant, requires further investigation

SEPARATION OF CESIUM AND ALUMINUM BY CATION-EXCHANGER PUROLITE C-160

The possibility of cesium separation from aluminum during conversion of waste of catalysts processing by use of сation-exchanger Purolite C-160 at different pH was studied. The separation of these elements was not possible in the pH range of (2,0 – 10,0)

Influence of TES-therapy on the character of stress-induced expression of C-FOS in the paraventricular nucleus of the hypothalamus

In this study, the ability of transcranial electrostimulation (TES-therapy) to inhibit the hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis (reflected in the change in the character of c-fcs expression by neurons in the paraventricular nucleus of the hypothalamus) under conditions of combined stress and orthostatic test was evaluated. The experimental animals were divided into two groups: subjected to stress (comparison group, n = 20) and subjected to stress under TES-therapy (main group, n = 20). The results of the study indicate that TES-therapy favorably affects the psychophysical characteristics of rats and negatively modulates the function of the HPA axis, which allows us to conclude that this technique is an effective approach to the treatment of stress-related disorders.В настоящем исследовании оценивалась способность транскраниальной электростимуляции (ТЭС-терапии) предотвращатъ гиперактивацию гипоталамо-гипофизарно-надпочечниковой (ГГН) оси (отражающуюся в изменении характера экспрессии c-fos нейронами паравентрикулярного ядра гипоталамуса) в условиях комбинированного стресса, в качестве модели которого использовались тест вынужденного плавания и ортостатический тест. С этой целью экспериментальные животные были разделены на две группы: подвергавшиеся стрессу (группа сравнения, п=20) и повергавшиеся стрессу и получавшие ТЭС-терапию (основная группа, п=20). Результаты исследования указывают на то, что ТЭС-терапия благоприятно воздействует на психофизические показатели крыс и отрицательно модулирует функцию ГГН оси. Это позволяет заключить, что данная методика является эффективным подходом к лечению ассоциированных со стрессом расстройств

TUNGSTEN SORPTION BY ANION-EXCHANGER PUROLITE A830

Sorption characteristics of anion-exchanger Purolite A830 by W from Na2WO3 solutions with pH 2.5-3.0 were determined. The value of dynamic exchange capacity of resin at full saturation was 458,51 kg W m-3. The 15% ammonia water solution was most effective eluent for W

The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBP β

Colorectal cancer is one of the most common cancers in the world. It is well known that the chronic inflammation can promote the progression of colorectal cancer (CRC). Recently, a number of studies revealed a potential association between colorectal inflammation, cancer progression, and infection caused by enterotoxigenic Bacteroides fragilis (ETBF). Bacterial enterotoxin activates spermine oxidase (SMO), which produces spermidine and H2O2 as byproducts of polyamine catabolism, which, in turn, enhances inflammation and tissue injury. Using qPCR analysis, we estimated the expression of SMOX gene and ETBF colonization in CRC patients. We found no statistically significant associations between them. Then we selected genes involved in polyamine metabolism, metabolic reprogramming, and inflammation regulation and estimated their expression in CRC. We observed overexpression of SMOX, ODC1, SRM, SMS, MTAP, c-Myc, C/EBPβ (CREBP), and other genes. We found that two mediators of metabolic reprogramming, inflammation, and cell proliferation c-Myc and C/EBPβ may serve as regulators of polyamine metabolism genes (SMOX, AZIN1, MTAP, SRM, ODC1, AMD1, and AGMAT) as they are overexpressed in tumors, have binding site according to ENCODE ChIP-Seq data, and demonstrate strong coexpression with their targets. Thus, increased polyamine metabolism in CRC could be driven by c-Myc and C/EBPβ rather than ETBF infection