Additional file 1 of LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization

Additional file 1: Supplementary Table 1. Primers for RT-qPCR. Supplementary Table 2. Sequences of shRNAs and siRNAs. Supplementary Table 3. Antibodies used in the study. Supplementary Table 4. Mass spectrometry of proteins pulled-down by LINC00240 in MGC80-3 cell

Additional file 2 of LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization

Additional file 2: Supplementary Figure 1. The relative expression levels of LINC00240 in human GES-1, MKN-28, MKN-45, AGS, BGC-823, HGC-27 and MGC-803 cell lines. ***P < 0.001. Supplementary Figure 2. Silencing of LINC00240 significantly promoted apoptosis of gastric cancer cells (A), but did not impact cell cycle (B). Supplementary Figure 3. Expression of apoptotic proteins (A), DDX21 and USP10 (B) in gastric cancer xenografts

The Acute toxicity study of bufadienolides on KM mice (n = 10).

<p>The Acute toxicity study of bufadienolides on KM mice (n = 10).</p

IC₅₀ of Cinobufacin components.

<p>IC₅₀ of Cinobufacin components.</p

Evaluation of antitumor effects of different Cinobufacin components.

<p>Growth inhibition effects of different concentrations of bufadienolides (Buf), alkaloids (Alk), nucleosides (Nuc), and peptides (Pep) extracted from Cinobufacin on BEL-7402 (A) and BGC-823 cells (B). Cells was monitored for 48hrs after adding different Cinobufacin extracts.</p

Effect of bufadienolides on H22 and MFC tumors.

<p>Effect of bufadienolides on H22 and MFC tumors.</p