The energy spectrum observed by the AGASA experiment and the spatial distribution of the sources of ultra-high energy cosmic rays

Seven and a half years of continuous monitoring of giant air showers triggered by ultra high-energy cosmic rays have been recently summarized by the AGASA collaboration. The resulting energy spectrum indicates clearly that the cosmic ray spectrum extends well beyond the Greisen-Zatsepin-Kuzmin (GZK) cut-off at $\sim 5 \times 10^{19}$ eV. Furthermore, despite the small number statistics involved, some structure in the spectrum may be emerging. Using numerical simulations, it is demonstrated in the present work that these features are consistent with a spatial distribution of sources that follows the distribution of luminous matter in the local Universe. Therefore, from this point of view, there is no need for a second high-energy component of cosmic rays dominating the spectrum beyond the GZK cut-off.Comment: 14 pages, 4 figures, Astrophys. J. Letters (submitted

On the Discovery of the GZK Cut-off

The recent claim of the '5 sigma' observation of the Greisen and Zatzepin and Kuzmin cut-off by the HiRes group based on their nine years data is a significant step toward the eventual solution of the one of the most intriguing questions which has been present in physics for more than forty years. However the word 'significance' is used in the mentioned paper in the sense which is not quite obvious. In the present paper we persuade that this claim is a little premature.Comment: 10 page

Ultra high energy neutrinos from gamma ray bursts

Protons accelerated to high energies in the relativistic shocks that generate gamma ray bursts photoproduce pions, and then neutrinos in situ. I show that ultra high energy neutrinos (> 10^19 eV) are produced during the burst and the afterglow. A larger flux, also from bursts, is generated via photoproduction off CMBR photons in flight but is not correlated with currently observable bursts, appearing as a bright background. Adiabatic/synchrotron losses from protons/pions/muons are negligible. Temporal and directional coincidences with bursts detected by satellites can separate correlated neutrinos from the background.Comment: Adiabatic/synchrotron losses from protons/pions/muons shown to be negligible. Accepted for publication in Phys. Rev. Letters. RevTe

Solar panels as air Cherenkov detectors for extremely high energy cosmic rays

Increasing interest towards the observation of the highest energy cosmic rays has motivated the development of new detection techniques. The properties of the Cherenkov photon pulse emitted in the atmosphere by these very rare particles indicate low-cost semiconductor detectors as good candidates for their optical read-out. The aim of this paper is to evaluate the viability of solar panels for this purpose. The experimental framework resulting from measurements performed with suitably-designed solar cells and large conventional photovoltaic areas is presented. A discussion on the obtained and achievable sensitivities follows.Comment: 6 pages, 8 eps figures included with epsfig, uses espcrc2.sty. Talk given at the Sixth Topical Seminar on Neutrino and Astroparticle Physics, San Miniato, Italy, 17-21 May 199

Decaying neutron propagation in the Galaxy and the Cosmic Ray anisotropy at 1 EeV

We study the cosmic ray arrival distribution expected from a source of neutrons in the galactic center at energies around 1 EeV and compare it with the anisotropy detected by AGASA and SUGAR. Besides the point-like signal in the source direction produced by the direct neutrons, an extended signal due to the protons produced in neutron decays is expected. This associated proton signal also leads to an excess in the direction of the spiral arm. For realistic models of the regular and random galactic magnetic fields, the resulting anisotropy as a function of the energy is obtained. We find that for the anisotropy to become sufficiently suppressed below E\sim 10^{17.9}eV, a significant random magnetic field component is required, while on the other hand, this also tends to increase the angular spread of the associated proton signal and to reduce the excess in the spiral arm direction. The source luminosity required in order that the right ascension anisotropy be 4% for the AGASA angular exposure corresponds to a prediction for the point-like flux from direct neutrons compatible with the flux detected by SUGAR. We also analyse the distinguishing features predicted for a large statistics southern observatory.Comment: 14 pages, 6 figures, minor changes to match published versio

Extreme Energy Cosmic Rays (EECR) Observation Capabilities of an "Airwatch from Space'' Mission

The longitudinal development and other characteristics of the EECR induced atmospheric showers can be studied from space by detecting the fluorescence light induced in the atmospheric nitrogen. According to the Airwatch concept a single fast detector can be used for measuring both intensity and time development of the streak of fluorescence light produced by the atmospheric shower induced by an EECR. In the present communication the detection capabilities for the EECR observation from space are discussed.Comment: 3 pages (LaTeX). To appear in the Proceedings of TAUP'9

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly understood. Here we perform TCRB sequencing, integration site analysis, and single-cell RNA sequencing (scRNA-seq) to profile CD8+ CAR-T cells from infusion products (IPs) and blood of patients undergoing CD19 CAR-T immunotherapy. TCRB sequencing shows that clonal diversity of CAR-T cells is highest in the IPs and declines following infusion. We observe clones that display distinct patterns of clonal kinetics, making variable contributions to the CAR-T cell pool after infusion. Although integration site does not appear to be a key driver of clonal kinetics, scRNA-seq demonstrates that clones that expand after infusion mainly originate from infused clusters with higher expression of cytotoxicity and proliferation genes. Thus, we uncover transcriptional programs associated with CAR-T cell behavior after infusion.Published versio

Features of Muon Arrival Time Distributions of High Energy EAS at Large Distances From the Shower Axis

In view of the current efforts to extend the KASCADE experiment (KASCADE-Grande) for observations of Extensive Air Showers (EAS) of primary energies up to 1 EeV, the features of muon arrival time distributions and their correlations with other observable EAS quantities have been scrutinised on basis of high-energy EAS, simulated with the Monte Carlo code CORSIKA and using in general the QGSJET model as generator. Methodically various correlations of adequately defined arrival time parameters with other EAS parameters have been investigated by invoking non-parametric methods for the analysis of multivariate distributions, studying the classification and misclassification probabilities of various observable sets. It turns out that adding the arrival time information and the multiplicity of muons spanning the observed time distributions has distinct effects improving the mass discrimination. A further outcome of the studies is the feature that for the considered ranges of primary energies and of distances from the shower axis the discrimination power of global arrival time distributions referring to the arrival time of the shower core is only marginally enhanced as compared to local distributions referring to the arrival of the locally first muon.Comment: 24 pages, Journal Physics G accepte

The Case for a Low Extragalactic Gamma-ray Background

Measurements of the diffuse extragalactic gamma-ray background (EGRB) are complicated by a strong Galactic foreground. Estimates of the EGRB flux and spectrum, obtained by modeling the Galactic emission, have produced a variety of (sometimes conflicting) results. The latest analysis of the EGRET data found an isotropic flux I_x=1.45+-0.05 above 100 MeV, in units of 10^-5 s^-1 cm^-2 sr^-1. We analyze the EGRET data in search for robust constraints on the EGRB flux, finding the gamma-ray sky strongly dominated by Galactic foreground even at high latitudes, with no conclusive evidence for an additional isotropic component. The gamma-ray intensity measured towards the Galactic poles is similar to or lower than previous estimates of I_x. The high latitude profile of the gamma-ray data is disk-like for 40<|b[deg]|<70, and even steeper for |b|>70; overall it exhibits strong Galactic features and is well fit by a simple Galactic model. Based on the |b|>40 data we find that I_x<0.5 at a 99% confidence level, with evidence for a much lower flux. We show that correlations with Galactic tracers, previously used to identify the Galactic foreground and estimate I_x, are not satisfactory; the results depend on the tracers used and on the part of the sky examined, because the Galactic emission is not linear in the Galactic tracers and exhibits spectral variations across the sky. The low EGRB flux favored by our analysis places stringent limits on extragalactic scenarios involving gamma-ray emission, such as radiation from blazars, intergalactic shocks and production of ultra-high energy cosmic rays and neutrinos. We suggest methods by which future gamma-ray missions such as GLAST and AGILE could indirectly identify the EGRB.Comment: Accepted for publication in JCAP. Increased sizes of polar regions examined, and added discussion of spectral data. Results unchange

The Extremely High Energy Cosmic Rays

Experimental results from Haverah Park, Yakutsk, AGASA and Fly's Eye are reviewed. All these experiments work in the energy range above 0.1 EeV. The 'dip' structure around 3 EeV in the energy spectrum is well established by all the experiments, though the exact position differs slightly. Fly's Eye and Yakutsk results on the chemical composition indicate that the cosmic rays are getting lighter over the energy range from 0.1 EeV to 10 EeV, but the exact fraction is hadronic interaction model dependent, as indicated by the AGASA analysis. The arrival directions of cosmic rays are largely isotropic, but interesting features may be starting to emerge. Most of the experimental results can best be explained with the scenario that an extragalactic component gradually takes over a galactic population as energy increases and cosmic rays at the highest energies are dominated by particles coming from extragalactic space. However, identification of the extragalactic sources has not yet been successful because of limited statistics and the resolution of the data.Comment: The review paper including 21 figures. 39 pages: To be published in Journal of Physics