T-2 toksin - pojavnost i toksičnost u peradi

T-2 toxin is the most toxic type A trichothecene mycotoxin. It is the secondary metabolite of the Fusarium fungi, and is common in grain and animal feed. Toxic effects have been shown both in experimental animals and in livestock. It has been implicated in several outbreaks of human mycotoxicoses. Toxic effects in poultry include inhibition of protein, DNA, and RNA synthesis, cytotoxicity, immunomodulation, cell lesions in the digestive tract, organs and skin, neural disturbances and low performance in poultry production (decreased weight gain, egg production, and hatchability). Concentrations of T-2 toxin in feed are usually low, and its immunosuppressive effects and secondary infections often make diagnosis difficult. If at the onset of the disease, a change in diet leads to health and performance improvements in animals, this may point to mycotoxin poisoning. Regular control of grain and feed samples is a valuable preventive measure, and it is accurate only if representative samples are tested. This article reviews the incidence and toxic effects of T-2 toxin in poultry.T-2 toksin je najtoksičniji predstavnik trikotecenskih mikotoksina tipa A. On je sekundarni produkt metabolizma plijesni roda Fusarium i često je prisutan u žitaricama i hrani za životinje. Štetni učinci uočeni su u eksperimentalnih životinja i životinja u uzgoju. On se povezuje s pojavom bolesti ljudi od mikotoksikoza. Učinci toksina u peradi su višestruki: inhibicija sinteze proteina, DNA i RNA, citotoksični učinak, imunomodulatorni učinak, oštećenje stanica probavnog sustava, organa i kože, živčani poremećaji te pad proizvodnih karakteristika u uzgoju peradi (slabiji prirast, pad nesivosti i valivosti). Koncentracije T-2 toksina u hrani redovito su vrlo malene, a zbog imunosupresivnog djelovanja toksina te istodobne sekundarne infekcije bolest se često teško dijagnosticira. Pri pojavi bolesti promjenom hrane može doći do poboljšanja zdravstvenog stanja, što tako|er upućuje na moguće trovanje mikotoksinima. Redovita kontrola uzoraka žitarica i hrane za životinje jedna je od preventivnih mjera, a detekcija mikotoksina u žitaricama i hrani pouzdana je samo ako se ispituje reprezentativan uzorak. U radu su opisani učestalost i toksični učinci T-2 toksina u peradi

Reverse accumulation and accurate rounding error estimates for taylor series coefficient

Original article can be found at: http://www.informaworld.com/smpp/title~content=t713645924~db=all Copyright Taylor and Francis/ Informa.We begin by extending the technique of reverse accumulation so as to obtain gradients of univariate Taylor series coefficients. This is done by re-interpreting the same formulae used to reverse accumulategradients in the conventional (scalar) case. Thus a carefully written implementation of conventional reverse accumulation can be extended to the Taylor series valued case by (further) overloading of the appropriate operators. Next, we show how to use this extended reverse accumulation technique so as to construct accurate (i.e. rigorous and sharp) error bounds for the numerical values of the Taylor series coefficients of the target function, again by re-interpreting the corresponding conventional (scalar) formulae. This extension can also be implemented simply by re-engineering existing code. The two techniques (reverse accumulation of gradients and accurate error estimates) each require only a small multiple of the processing time required to compute the underlying Taylor series coefficients. Space "requirements are comparable to those for conventional (scalar) reverse accumulation, and can be simply managed. We concluded with a discussion of possible implementation strategies and the implications for the re-use of code.Peer reviewe